{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T04:06:38Z","timestamp":1750824398653,"version":"3.41.0"},"reference-count":16,"publisher":"Jaypee Brothers Medical Publishing","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.59556\/japi.73.0805","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T07:24:34Z","timestamp":1750749874000},"page":"70-72","source":"Crossref","is-referenced-by-count":0,"title":["Unraveling the Mysteries: Paroxysmal Nocturnal Hemoglobinuria and Its Unexpected Link to Stroke in Young Adult"],"prefix":"10.59556","volume":"73","author":[{"given":"Sachin","family":"Bharti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritu","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhay","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2914","reference":[{"issue":"(1):","key":"key20250624072427_B1","doi-asserted-by":"crossref","first-page":"3\u2013","DOI":"10.4103\/aian.AIAN_1123_21","article-title":"Stroke in young adults: an Indian perspective.","volume":"25","author":"Elavarasi","year":"2022;","journal-title":"Ann Indian Acad Neurol"},{"issue":"(11):","key":"key20250624072427_B2","doi-asserted-by":"crossref","first-page":"1379\u2013","DOI":"10.1007\/s00415-005-0871-3","article-title":"Cerebral ischemic infarction in paroxysmal nocturnal hemoglobinuria report of 2 cases and updated review of 7 previously published patients.","volume":"252","author":"Audebert","year":"2005;","journal-title":"J Neurol"},{"issue":"(6):","key":"key20250624072427_B3","doi-asserted-by":"crossref","first-page":"709\u2013","DOI":"10.1111\/j.1365-2141.2011.08690.x","article-title":"Management of paroxysmal nocturnal haemoglobinuria: a personal view.","volume":"153","author":"Luzzatto","year":"2011;","journal-title":"Br J Haematol"},{"issue":"(9):","key":"key20250624072427_B4","doi-asserted-by":"crossref","first-page":"822\u2013","DOI":"10.1182\/blood.V5.9.822.822","article-title":"Paroxysmal nocturnal hemoglobinuria; the mechanism of hemolysis and its relation to the coagulation mechanism.","volume":"5","author":"Crosby","year":"1950;","journal-title":"Blood"},{"issue":"(35):","key":"key20250624072427_B5","doi-asserted-by":"crossref","first-page":"25347\u2013","DOI":"10.1016\/S0021-9258(19)74046-0","article-title":"Affected paroxysmal nocturnal hemoglobinuria T lymphocytes harbor a common defect in assembly of N-acetyl-D-glucosamine inositol phospholipid corresponding to that in class A Thy-1-murine lymphoma mutants.","volume":"267","author":"Armstrong","year":"1992;","journal-title":"J Biol Chem"},{"issue":"(1):","key":"key20250624072427_B6","doi-asserted-by":"crossref","first-page":"7\u2013","DOI":"10.1172\/JCI114172","article-title":"Isolation and characterization of a membrane protein from normal human erythrocytes that inhibits reactive lysis of the erythrocytes of paroxysmal nocturnal hemoglobinuria.","volume":"84","author":"Holguin","year":"1989;","journal-title":"J Clin Invest"},{"issue":"(18):","key":"key20250624072427_B7","doi-asserted-by":"crossref","first-page":"2804\u2013","DOI":"10.1182\/blood-2014-02-522128","article-title":"Paroxysmal nocturnal hemoglobinuria.","volume":"124","author":"Brodsky","year":"2014;","journal-title":"Blood"},{"issue":"(6):","key":"key20250624072427_B8","doi-asserted-by":"crossref","first-page":"1143\u2013","DOI":"10.1016\/j.cell.2009.11.001","article-title":"Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo.","volume":"139","author":"M\u00fcller","year":"2009;","journal-title":"Cell"},{"issue":"(6):","key":"key20250624072427_B9","doi-asserted-by":"crossref","first-page":"530\u2013","DOI":"10.1177\/0961203308099974","article-title":"Serum complement activation on heterologous platelets is associated with arterial thrombosis in patients with systemic lupus erythematosus and antiphospholipid antibodies.","volume":"18","author":"Peerschke","year":"2009;","journal-title":"Lupus"},{"issue":"(6):","key":"key20250624072427_B10","doi-asserted-by":"crossref","first-page":"1183\u2013","DOI":"10.1046\/j.1538-7836.2003.00180.x","article-title":"Nitric oxide and its relationship to thrombotic disorders.","volume":"1","author":"Freedman","year":"2003;","journal-title":"J Thromb Haemost"},{"issue":"(2):","key":"key20250624072427_B11","doi-asserted-by":"crossref","first-page":"129\u2013","DOI":"10.1080\/10739680490278402","article-title":"The endothelial biology of sickle cell disease: inflammation and a chronic vasculopathy.","volume":"11","author":"Hebbel","year":"2004;","journal-title":"Microcirculation"},{"issue":"(25):","key":"key20250624072427_B12","doi-asserted-by":"crossref","first-page":"4985\u2013","DOI":"10.1182\/blood-2012-09-311381","article-title":"Thrombosis in paroxysmal nocturnal hemoglobinuria.","volume":"121","author":"Hill","year":"2013;","journal-title":"Blood"},{"issue":"(10):","key":"key20250624072427_B13","doi-asserted-by":"crossref","first-page":"1304\u2013","DOI":"10.1182\/blood.2019003812","article-title":"How I treat paroxysmal nocturnal hemoglobinuria.","volume":"137","author":"Brodsky","year":"2021;","journal-title":"Blood"},{"issue":"(2):","key":"key20250624072427_B14","doi-asserted-by":"crossref","first-page":"297\u2013","DOI":"10.1111\/bjh.15790","article-title":"Eculizumab in paroxysmal nocturnal haemoglobinuria and atypical haemolytic uraemic syndrome: 10-year pharmacovigilance analysis.","volume":"185","author":"Soci\u00e9","year":"2019;","journal-title":"Br J Haematol"},{"key":"key20250624072427_B15","unstructured":"Ravulizumab-cwvz injection, for intravenous use. U.S. Food and Drug. Administration. Available at: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2022\/761108s023lbl.pdf (Accessed on December 25, 2023)."},{"issue":"(23):","key":"key20250624072427_B16","doi-asserted-by":"crossref","first-page":"3361\u2013","DOI":"10.1182\/blood.2021014868","article-title":"Pegcetacoplan for paroxysmal nocturnal hemoglobinuria.","volume":"139","author":"Gerber","year":"2022;","journal-title":"Blood"}],"container-title":["Journal of The Association of Physicians of India"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T07:24:37Z","timestamp":1750749877000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.japi.org\/article\/japi-73-1-70"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.59556\/japi.73.0805"],"URL":"https:\/\/doi.org\/10.59556\/japi.73.0805","relation":{},"ISSN":["0004-5772"],"issn-type":[{"value":"0004-5772","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]}}}