{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T14:21:38Z","timestamp":1789222898596,"version":"build-2803163510"},"reference-count":42,"publisher":"Jaypee Brothers Medical Publishing","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.59556\/japi.73.0936","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T06:23:01Z","timestamp":1751005381000},"page":"70-78","source":"Crossref","is-referenced-by-count":1,"title":["Montelukast: A Scientific and Legal Review"],"prefix":"10.59556","volume":"73","author":[{"given":"Mangesh","family":"Tiwaskar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaumik J","family":"Kamdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pralhad P","family":"Prabhudesai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2914","reference":[{"issue":"(1):","key":"key20250627062259_B1","doi-asserted-by":"crossref","first-page":"47\u2013","DOI":"10.1177\/2040622310383343","article-title":"Montelukast in asthma: a review of its efficacy and place in therapy.","volume":"2","author":"Paggiaro","year":"2011;","journal-title":"Ther Adv Chronic Dis"},{"issue":"(5):","key":"key20250627062259_B2","doi-asserted-by":"crossref","first-page":"e2213643.","DOI":"10.1001\/jamanetworkopen.2022.13643","article-title":"Analysis of neuropsychiatric diagnoses after montelukast initiation.","volume":"5","author":"Paljarvi","year":"2022;","journal-title":"JAMA Netw Open"},{"key":"key20250627062259_B3","unstructured":"U.S. Food and Drug Administration. https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-requires-boxed-warning-about-serious-mental-health-side-effects-asthma-and-allergy-drug."},{"issue":"(3):","key":"key20250627062259_B4","first-page":"368\u2013","article-title":"The effect of inhaled leukotriene D4 in humans.","volume":"131","author":"Smith","year":"1985;","journal-title":"Am Rev Respir Dis"},{"issue":"(2):","key":"key20250627062259_B5","doi-asserted-by":"crossref","first-page":"191\u2013","DOI":"10.1139\/y95-028","article-title":"Pharmacology of montelukast sodium (Singulair), a potent and selective leukotriene D4 receptor antagonist.","volume":"73","author":"Jones","year":"1995;","journal-title":"Can J Physiol Pharmacol"},{"issue":"(3):","key":"key20250627062259_B6","doi-asserted-by":"crossref","first-page":"147\u2013","DOI":"10.1056\/NEJM199807163390302","article-title":"Montelukast, a leukotriene-receptor antagonist, for the treatment of mild asthma and exercise-induced bronchoconstriction.","volume":"339","author":"Leff","year":"1998;","journal-title":"N Engl J Med"},{"key":"key20250627062259_B7","unstructured":"U.S. Food and Drug Administration. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/98\/020829s000_Singular_AP_Ltr.pdf."},{"issue":"(3):","key":"key20250627062259_B8","first-page":"501\u2013","article-title":"Allergic rhinitis: a review of the current evidence and guidelines.","volume":"126","author":"Brozek","year":"2010;","journal-title":"J Allergy Clin Immunol"},{"issue":"(4597):","key":"key20250627062259_B9","doi-asserted-by":"crossref","first-page":"568\u2013","DOI":"10.1126\/science.6301011","article-title":"Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation.","volume":"220","author":"Samuelsson","year":"1983;","journal-title":"Science"},{"issue":"(6738):","key":"key20250627062259_B10","doi-asserted-by":"crossref","first-page":"789\u2013","DOI":"10.1038\/21658","article-title":"Characterization of the human cysteinyl leukotriene CysLT1 receptor.","volume":"399","author":"Lynch","year":"1999;","journal-title":"Nature"},{"issue":"(3):","key":"key20250627062259_B11","doi-asserted-by":"crossref","first-page":"173\u2013","DOI":"10.1517\/14740338.3.3.173","article-title":"Leukotriene receptor antagonists\u2013risks and benefits for use in paediatric asthma.","volume":"3","author":"Spahr","year":"2004;","journal-title":"Expert Opin Drug Saf"},{"key":"key20250627062259_B12","doi-asserted-by":"crossref","DOI":"10.1007\/s10787-024-01557-1","article-title":"Leukotriene signaling in neurodegeneration: implications for treatment strategies.","author":"Sharma","year":"2024.","journal-title":"Inflammopharmacology"},{"issue":"(9):","key":"key20250627062259_B13","doi-asserted-by":"crossref","first-page":"4837.","DOI":"10.3390\/ijms22094837","article-title":"Serotonin-its synthesis and roles in the healthy and the critically ill.","volume":"22","author":"Kanova","year":"2021;","journal-title":"Int J Mol Sci"},{"key":"key20250627062259_B14","doi-asserted-by":"crossref","first-page":"764279.","DOI":"10.3389\/fphar.2021.764279","article-title":"Neuropsychiatric adverse events of montelukast: an analysis of real-world datasets and drug-gene interaction network.","volume":"12:","author":"Umetsu","year":"2021;","journal-title":"Front Pharmacol"},{"key":"key20250627062259_B15","doi-asserted-by":"crossref","first-page":"199\u2013","DOI":"10.1016\/j.neuroscience.2013.04.060","article-title":"Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications.","volume":"246:","author":"Felger","year":"2013;","journal-title":"Neuroscience"},{"key":"key20250627062259_B16","doi-asserted-by":"crossref","first-page":"515.","DOI":"10.3389\/fneur.2019.00515","article-title":"The role of BDNF in the neuroimmune axis regulation of mood disorders.","volume":"10:","author":"Jin","year":"2019;","journal-title":"Front Neurol"},{"key":"key20250627062259_B17","doi-asserted-by":"crossref","first-page":"67\u2013","DOI":"10.2174\/1874306401812010067","article-title":"Effect of montelukast 10 mg in elderly patients with mild and moderate asthma compared with young adults. Results of a cohort study.","volume":"12:","author":"S\u00e1nchez","year":"2018;","journal-title":"Open Respir Med J"},{"issue":"(4):","key":"key20250627062259_B18","doi-asserted-by":"crossref","first-page":"345\u2013","DOI":"10.29271\/jcpsp.2019.04.345","article-title":"Montelukast and budesonide for childhood cough variant asthma.","volume":"29","author":"Sun","year":"2019;","journal-title":"J Coll Physicians Surg Pak"},{"issue":"(17):","key":"key20250627062259_B19","doi-asserted-by":"crossref","first-page":"1831\u2013","DOI":"10.1007\/s40265-020-01406-9","article-title":"Efficacy of montelukast in allergic rhinitis treatment: a systematic review and meta-analysis.","volume":"80","author":"Krishnamoorthy","year":"2020;","journal-title":"Drugs"},{"issue":"(11):","key":"key20250627062259_B20","doi-asserted-by":"crossref","first-page":"845\u2013","DOI":"10.1358\/dot.2008.44.11.1297498","article-title":"Montelukast sodium for exercise-induced asthma.","volume":"44","author":"de Benedictis","year":"2008;","journal-title":"Drugs Today (Barc)"},{"issue":"(2):","key":"key20250627062259_B21","first-page":"123\u2013","article-title":"Montelukast prevents exercise-induced bronchoconstriction.","volume":"30","author":"Matz","year":"2000;","journal-title":"Pediatr Pulmonol"},{"key":"key20250627062259_B22","unstructured":"Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. 2024. Available from: https:\/\/ginasthma.org\/gina-reports\/"},{"key":"key20250627062259_B23","unstructured":"Indian Chest Society. Guidelines for Diagnosis and Management of Asthma: Indian Consensus. Lung India. 2015. Available from: https:\/\/journals.lww.com\/lungindia\/fulltext\/2015\/32001\/guidelines_for_diagnosis_and_management_of.2.aspx"},{"key":"key20250627062259_B24","unstructured":"National Heart, Lung, and Blood Institute. 2020 Focused Updates to Asthma Management Guidelines. Available from: https:\/\/www.nhlbi.nih.gov\/resources\/2020-focused-updates-asthma-management-guidelines"},{"key":"key20250627062259_B25","doi-asserted-by":"crossref","unstructured":"European Respiratory Review. Montelukast in Asthma Management. 2023. Available from: https:\/\/err.ersjournals.com\/content\/errev\/32\/170\/230124.full.pdf","DOI":"10.1183\/16000617.0124-2023"},{"key":"key20250627062259_B26","unstructured":"Japanese Society of Allergology. Guidelines for Allergic Rhinitis and Asthma 2021. Available from: https:\/\/www.jsa.or.jp\/modules\/guideline\/"},{"key":"key20250627062259_B27","unstructured":"Bousquet J, Toumi M, Sousa-Pinto B, et al. ARIA 2023 Guidelines. Available from: https:\/\/www.whiar.org\/pages\/ARIA-Guidelines"},{"key":"key20250627062259_B28","unstructured":"https:\/\/www.nice.org.uk\/guidance\/ng80"},{"issue":"(7):","key":"key20250627062259_B29","first-page":"e16137.","article-title":"The addition of montelukast for the treatment of chronic idiopathic urticaria.","volume":"13","author":"Alkeraye","year":"2021;","journal-title":"Cureus"},{"issue":"(4):","key":"key20250627062259_B30","doi-asserted-by":"crossref","first-page":"241\u2013","DOI":"10.1016\/j.wjorl.2020.07.009","article-title":"Aspirin-exacerbated respiratory disease: update on medical management.","volume":"6","author":"White","year":"2020;","journal-title":"World J Otorhinolaryngol Head Neck Surg"},{"key":"key20250627062259_B31","doi-asserted-by":"crossref","first-page":"193\u2013","DOI":"10.1016\/j.sleep.2020.11.009","article-title":"The efficacy and safety of montelukast in children with obstructive sleep apnea: a systematic review and meta-analysis.","volume":"78:","author":"Ji","year":"2021;","journal-title":"Sleep Med"},{"issue":"(1):","key":"key20250627062259_B32","doi-asserted-by":"crossref","first-page":"129\u2013","DOI":"10.1007\/s10571-020-00841-2","article-title":"The novel potential therapeutic utility of montelukast in alleviating autistic behavior induced by early postnatal administration of thimerosal in mice.","volume":"41","author":"Abdelzaher","year":"2021;","journal-title":"Cell Mol Neurobiol"},{"issue":"(6):","key":"key20250627062259_B33","doi-asserted-by":"crossref","first-page":"599\u2013","DOI":"10.1016\/S1081-1206(10)62108-4","article-title":"Anti-inflammatory effects of montelukast in mild cystic fibrosis.","volume":"89","author":"Schmitt-Groh\u00e9","year":"2002;","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"(169):","key":"key20250627062259_B34","doi-asserted-by":"crossref","first-page":"230079.","DOI":"10.1183\/16000617.0079-2023","article-title":"Neuropsychiatric events associated with montelukast in patients with asthma: a systematic review.","volume":"32","author":"Lo","year":"2023;","journal-title":"Eur Respir Rev"},{"key":"key20250627062259_B35","unstructured":"https:\/\/www.reuters.com\/investigates\/special-report\/usa-lawsuits-merck-singulair\/."},{"key":"key20250627062259_B36","unstructured":"https:\/\/www.forbes.com\/advisor\/legal\/product-liability\/singulair-lawsuit\/."},{"key":"key20250627062259_B37","unstructured":"https:\/\/www.canada.ca\/en\/health-canada\/services\/drugs-health-products\/medeffect-canada\/health-product-infowatch\/august-2020.html#a5.1."},{"key":"key20250627062259_B38","unstructured":"https:\/\/www.ema.europa.eu\/en\/documents\/psusa\/montelukast-cmdh-scientific-conclusions-and-grounds-variation-amendments-product-information-and-timetable-implementation-psusa00002087201807_en.pdf."},{"key":"key20250627062259_B39","unstructured":"https:\/\/www.tga.gov.au\/news\/safety-alerts\/montelukast."},{"key":"key20250627062259_B40","unstructured":"https:\/\/www.medsafe.govt.nz\/profs\/datasheet\/m\/MontelukastMylanTab.pdf#:~:text=Patients%2C%20and%2For%20caregivers%20and%20physicians%20should%20be%20alert,if%20these%20changes%20occur%20and%20to%20discontinue%20treatment."},{"key":"key20250627062259_B41","unstructured":"https:\/\/www.hsa.gov.sg\/announcements\/safety-alert\/advisory-on-restriction-on-the-use-of-montelukast-and-neuropsychiatric-effects."},{"issue":"(12):","key":"key20250627062259_B42","first-page":"1\u2013","article-title":"Efficacy of seratrodast, a thromboxane A2 receptor inhibitor in a double-blind comparative clinical trial with montelukast.","volume":"12","author":"Dewan","year":"2015;","journal-title":"J Adv Med Med Res"}],"container-title":["Journal of The Association of Physicians of India"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T06:23:08Z","timestamp":1751005388000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.japi.org\/article\/japi-73-5-70"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025]]}},"alternative-id":["10.59556\/japi.73.0936"],"URL":"https:\/\/doi.org\/10.59556\/japi.73.0936","relation":{},"ISSN":["0004-5772"],"issn-type":[{"value":"0004-5772","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]}}}