{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:03:45Z","timestamp":1785305025386,"version":"3.55.0"},"reference-count":0,"publisher":"Jaypee Brothers Medical Publishing","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPI"],"published-print":{"date-parts":[[2025,11,10]]},"abstract":"<jats:p>The weight of the matter in diabetes care challenges the traditional glucose-centric model of \ndiabetes management and argues for a paradigm shift toward prioritizing weight\u2014specifically \nfat reduction\u2014as the central lever in achieving metabolic health. Drawing insights from landmark \ntrials such as SURMOUNT and Diabetes Remission Clinical Trial (DiRECT), as well as real-world Indian \nexperience with agents like oral semaglutide, the article emphasizes that visceral adiposity is a root \ncause driving insulin resistance, beta-cell dysfunction, and multiorgan complications. Addressing \nweight early can lead to improved glycemic control, cardiorenal protection, and even disease \nremission\u2014outcomes that far exceed glucose lowering alone. In the Indian context, where the \n\u201cthin\u2013fat\u201d phenotype and central obesity present unique challenges, this weight-first approach \ndemands culturally sensitive strategies and redefined success metrics beyond body mass index \n(BMI) or hemoglobin A1c (HbA1c). With the advent of incretin-based therapies, clinicians now \nhave the tools to treat upstream rather than manage symptoms downstream. The piece calls for \na unified therapeutic strategy that targets excess adiposity to deliver both glycemic and vascular \nlegacy benefits\u2014reframing weight not merely as a number but as a powerful determinant of \nrisk, response, and recovery.<\/jats:p>","DOI":"10.59556\/japi.73.1201","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T11:47:56Z","timestamp":1766058476000},"page":"87-88","source":"Crossref","is-referenced-by-count":1,"title":["The Weight of the Matter in Diabetes Care"],"prefix":"10.59556","volume":"73","author":[{"given":"Supratik","family":"Bhattacharyya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2914","published-online":{"date-parts":[[2025,11,10]]},"container-title":["Journal of the Association of Physicians of India"],"original-title":[],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T11:48:02Z","timestamp":1766058482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.japi.org\/article\/japi-73-11-87"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,10]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,10]]},"published-print":{"date-parts":[[2025,11,10]]}},"URL":"https:\/\/doi.org\/10.59556\/japi.73.1201","relation":{},"ISSN":["0004-5772"],"issn-type":[{"value":"0004-5772","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,10]]}}}