{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:20:37Z","timestamp":1766049637290,"version":"3.48.0"},"reference-count":0,"publisher":"Jaypee Brothers Medical Publishing","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPI"],"published-print":{"date-parts":[[2025,11,10]]},"abstract":"<jats:p>Background: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare \nautoimmune neuroinflammatory disorder. While it typically presents as optic neuritis, myelitis, \nor acute disseminated encephalomyelitis (ADEM), its manifestation as pyrexia of unknown origin \n(PUO) with subsequent meningitis is extremely rare.\nCase description: We report a 17-year-old male who presented with persistent fever and \nheadache, without focal neurological deficits. Extensive infectious workup was inconclusive. \nCerebrospinal fluid (CSF) analysis revealed mild pleocytosis, and empirical antibiotics were \ninitiated without clinical improvement. A repeat CSF analysis demonstrated worsening \npleocytosis, prompting an expanded autoimmune and neuroinflammatory panel. MOG-IgG \nantibodies were detected in both serum and CSF, confirming the diagnosis of MOGAD. The \npatient responded well to high-dose corticosteroids followed by mycophenolate mofetil for \nmaintenance therapy.\nConclusion: This case highlights the importance of considering MOGAD in patients with \nunexplained fever and headache with inflammatory CSF. Early recognition and prompt \nimmunotherapy initiation are essential for optimal outcomes. A favorable outcome was observed \nfollowing timely immunotherapy.<\/jats:p>","DOI":"10.59556\/japi.73.1218","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:17:13Z","timestamp":1766049433000},"page":"57-59","source":"Crossref","is-referenced-by-count":0,"title":["Atypical Presentation of Myelin Oligodendrocyte Glycoprotein  Antibody Disease as Pyrexia of Unknown Origin with  Meningitis: A Case Report"],"prefix":"10.59556","volume":"73","author":[{"given":"Vanraj Nathabhai","family":"Padhiyar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vimal J","family":"Pahuja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Maitra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilesh Vijay","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanu","family":"Singhal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2914","published-online":{"date-parts":[[2025,11,10]]},"container-title":["Journal of the Association of Physicians of India"],"original-title":[],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:17:19Z","timestamp":1766049439000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.japi.org\/article\/japi-73-11-s1-57"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,10]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,10]]},"published-print":{"date-parts":[[2025,11,10]]}},"URL":"https:\/\/doi.org\/10.59556\/japi.73.1218","relation":{},"ISSN":["0004-5772"],"issn-type":[{"value":"0004-5772","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,10]]}}}