{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:10:55Z","timestamp":1766049055982,"version":"3.48.0"},"reference-count":0,"publisher":"Jaypee Brothers Medical Publishing","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPI"],"published-print":{"date-parts":[[2025,11,10]]},"abstract":"<jats:p>Human immunodeficiency virus (HIV)-negative acquired adult immunodeficiency diseases are rare \nand relatively difficult to diagnose and treat. Good\u2019s syndrome is one such rare immunodeficiency \nsyndrome occurring in middle to late adulthood. It is an association of combined B-cell and \nT-cell immunodeficiency along with hypogammaglobulinemia with a background of thymoma. \nHere, we describe a case of a 57-year-old male who presented to us with recurrent streptococcal \npneumonia. He had a past history of an operated thymoma, cytomegalovirus retinitis, and pure red \ncell aplasia (PRCA). Evaluation revealed hypogammaglobulinemia along with CD4+ T-cell and B-cell \nlymphopenia, thus indicating Good\u2019s syndrome. Our case highlights the importance of including \nGood\u2019s syndrome in the differential diagnosis of HIV-negative, acquired, adult immunodeficiency \nand elucidates the general principles of management of this rare clinical entity.<\/jats:p>","DOI":"10.59556\/japi.73.1219","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:06:23Z","timestamp":1766048783000},"page":"50-51","source":"Crossref","is-referenced-by-count":0,"title":["Good\u2019s Syndrome\u2014A Rare Cause of Acquired Adult  Immunodeficiency: A Case Report"],"prefix":"10.59556","volume":"73","author":[{"given":"Ruchir B","family":"Deshpande","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narendra","family":"Javdekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2914","published-online":{"date-parts":[[2025,11,10]]},"container-title":["Journal of the Association of Physicians of India"],"original-title":[],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:06:26Z","timestamp":1766048786000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.japi.org\/article\/japi-73-11-s1-50"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,10]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,10]]},"published-print":{"date-parts":[[2025,11,10]]}},"URL":"https:\/\/doi.org\/10.59556\/japi.73.1219","relation":{},"ISSN":["0004-5772"],"issn-type":[{"value":"0004-5772","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,10]]}}}