{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T02:47:33Z","timestamp":1777085253790,"version":"3.51.4"},"reference-count":0,"publisher":"Jaypee Brothers Medical Publishing","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPI"],"published-print":{"date-parts":[[2025,11,10]]},"abstract":"<jats:p>Background: Iron deficiency anemia (IDA) affects approximately 2 billion individuals globally, yet \noptimal response to oral iron supplementation remains unpredictable. The oral iron absorption \ntest (OIAT) represents a potentially valuable diagnostic tool for predicting therapeutic response \nand identifying underlying gastrointestinal malabsorption syndromes.\nMaterials and methods: This prospective study enrolled 190 IDA patients at a tertiary care center. \nAfter collecting baseline hematological parameters, participants underwent OIAT by receiving  \n60 mg of elemental iron, with serum iron levels measured at baseline and after 2 hours. Patients with \nabnormal OIAT results underwent additional investigations to identify underlying malabsorption \nsyndromes. Results: Among the participants (mean age 32.34 \u00b1 11.84 years, 90.5% female), 34.2% demonstrated \nabnormal OIAT results. Malabsorption was diagnosed in 19.5% of subjects, with Helicobacter pylori \ninfection (54.1%), autoimmune gastritis (27.0%), and celiac disease (18.9%) as the predominant \netiologies. OIAT showed excellent sensitivity (89.2%), good specificity (79.1%), and exceptional \nnegative predictive value (97.6%) for identifying malabsorption syndromes.\nConclusions: OIAT demonstrates robust diagnostic performance for predicting response to oral \niron therapy and identifying malabsorption syndromes in IDA. The high negative predictive value \npositions OIAT as an effective first-line screening tool, potentially reducing the need for invasive \ninvestigations in patients with normal test results.<\/jats:p>","DOI":"10.59556\/japi.73.1222","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T10:06:42Z","timestamp":1766052402000},"page":"20-23","source":"Crossref","is-referenced-by-count":1,"title":["Oral Iron Absorption Test as a Predictor of Response to Oral  Iron Therapy and Gastrointestinal Malabsorption Syndromes in  Iron Deficiency Anemia"],"prefix":"10.59556","volume":"73","author":[{"given":"Sanyam","family":"Gaur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishnu","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varsha","family":"Gaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vansh","family":"Bagrodia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2914","published-online":{"date-parts":[[2025,11,10]]},"container-title":["Journal of the Association of Physicians of India"],"original-title":[],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T10:06:42Z","timestamp":1766052402000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.japi.org\/article\/japi-73-11-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,10]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,10]]},"published-print":{"date-parts":[[2025,11,10]]}},"URL":"https:\/\/doi.org\/10.59556\/japi.73.1222","relation":{},"ISSN":["0004-5772"],"issn-type":[{"value":"0004-5772","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,10]]}}}