{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:10:54Z","timestamp":1766049054464,"version":"3.48.0"},"reference-count":0,"publisher":"Jaypee Brothers Medical Publishing","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPI"],"published-print":{"date-parts":[[2025,11,10]]},"abstract":"<jats:p>Background: Anemia and iron deficiency are frequently observed in patients with heart \nfailure (HF) and are independently linked to adverse outcomes. Although intravenous (IV) iron \nsupplementation is well studied in HF with reduced ejection fraction, its impact on coexisting \nsignificant valvular disease remains poorly understood.\nCase description: A 67-year-old female with a known history of coronary artery disease, \ndiabetes, hypertension, hypothyroidism, and chronic kidney disease presented with exertional \nbreathlessness and fatigue. Workup revealed severe anemia (hemoglobin 6.1 gm\/dL), reduced \nleft ventricular ejection fraction (LVEF 45%), severe mitral regurgitation (MR), and mild tricuspid \nregurgitation (TR). She was managed conservatively with IV iron and two units of leukocyte\ndepleted packed red blood cells (LD PRBCs). Over the next few days, the patient experienced \nmarked clinical improvement. Repeat echocardiography demonstrated normalization of LVEF, \ndowngrading of MR severity from severe to mild, regression of TR, and complete resolution of \npericardial effusion. Her hemoglobin improved to 8.0 gm\/dL.\nDiscussion: This case underscores the role of severe anemia as a modifiable factor contributing to \ncardiac dysfunction, including reversible valvular insufficiency and reduced systolic performance. \nRestoration of hemoglobin levels led to significant clinical and echocardiographic recovery, \npointing to anemia as a potential therapeutic target in such cases. The use of IV iron proved \nbeneficial in facilitating this improvement.\nConclusion: In older patients with multiple comorbidities and new or worsening cardiac \ndysfunction, severe anemia should be considered a treatable cause. Early diagnosis and targeted \ntherapy using IV iron and transfusion can result in substantial clinical gains and may help avoid \nunnecessary invasive procedures.<\/jats:p>","DOI":"10.59556\/japi.73.1224","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:06:23Z","timestamp":1766048783000},"page":"43-44","source":"Crossref","is-referenced-by-count":0,"title":["Improvement in Severe Mitral Regurgitation and Left  Ventricular Dysfunction with Intravenous Iron in Severe  Anemia: A Case Report"],"prefix":"10.59556","volume":"73","author":[{"given":"Pawan","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himanshu","family":"Jindal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urvashi","family":"Arora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakshi","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2914","published-online":{"date-parts":[[2025,11,10]]},"container-title":["Journal of the Association of Physicians of India"],"original-title":[],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:06:24Z","timestamp":1766048784000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.japi.org\/article\/japi-73-11-s1-43"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,10]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,10]]},"published-print":{"date-parts":[[2025,11,10]]}},"URL":"https:\/\/doi.org\/10.59556\/japi.73.1224","relation":{},"ISSN":["0004-5772"],"issn-type":[{"value":"0004-5772","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,10]]}}}