{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:59:23Z","timestamp":1788274763801,"version":"build-2803163510"},"reference-count":0,"publisher":"Jaypee Brothers Medical Publishing","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPI"],"published-print":{"date-parts":[[2025,11,10]]},"abstract":"<jats:p>Mitochondrial encephalopathy with lactic acidosis and stroke-like episodes, also known as \nMELAS, is an uncommon genetic disorder of mitochondrial inheritance. It presents as variable \nneurological and systemic manifestations. Here, we present a case of a young male who was \na known case of seizure disorder and multiple neurological deficits. His clinical presentation \nincluded progressive hearing loss, diminution of vision, and recurrent headaches with vomiting. \nNeurological examination showed asymmetric limb weakness. Young-onset stroke was evaluated, \nand a magnetic resonance imaging (MRI) scan showed bilateral parieto-occipital hyperintensities. \nSerum lactate levels were high, which increased the suspicion of MELAS. m.3243A&gt;G mutation \nwas detected in mitochondrial DNA, confirming the diagnosis. Treatment involved the adjustment \nof antiepileptic therapy and the initiation of mitochondrial supplements. Our case emphasizes \nthe heterogeneous clinical presentation and diagnostic challenges of MELAS as an important \ncause of young-onset stroke, highlighting the importance of early suspicion and confirmatory \ninvestigations for personalized management strategies to optimize patient outcomes.<\/jats:p>","DOI":"10.59556\/japi.73.1235","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T07:48:52Z","timestamp":1766044132000},"page":"24-26","source":"Crossref","is-referenced-by-count":1,"title":["Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke like Episodes: A Masquerader of Young-onset Stroke"],"prefix":"10.59556","volume":"73","author":[{"given":"Kartik","family":"Goel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divyanshu","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin A","family":"Jambagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Bhargav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsh","family":"Kansagara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2914","published-online":{"date-parts":[[2025,11,10]]},"container-title":["Journal of the Association of Physicians of India"],"original-title":[],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T07:48:54Z","timestamp":1766044134000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.japi.org\/article\/japi-73-11-s1-24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,10]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,10]]},"published-print":{"date-parts":[[2025,11,10]]}},"URL":"https:\/\/doi.org\/10.59556\/japi.73.1235","relation":{},"ISSN":["0004-5772"],"issn-type":[{"value":"0004-5772","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,10]]}}}