{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:43:12Z","timestamp":1781196192478,"version":"3.54.1"},"reference-count":0,"publisher":"Jaypee Brothers Medical Publishing","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPI"],"published-print":{"date-parts":[[2025,11,10]]},"abstract":"<jats:p>Introduction: Nontyphoidal Salmonella (NTS) is a significant cause of food- and water-transmitted \nillness in the world, with the burden amplified in low-socioeconomic countries such as India. \nWhile most infections present as self-limiting gastroenteritis, vulnerable populations may develop \ninvasive nontyphoidal salmonellosis (iNTS). This study aimed to determine the prevalence, clinical \nspectrum, serotype distribution, and antimicrobial resistance patterns of NTS isolates in a tertiary \ncare hospital.\nMaterials and methods: A total of 61 NTS isolates were recovered from clinical samples, including \nstool, blood, pus, and urine. Identification was performed using the VITEK-2 system, and serotyping \nof fifteen isolates was done at the National Salmonella and Escherichia Center, Central Research \nInstitute (CRI), Kasauli, Himachal Pradesh. Antimicrobial susceptibility testing was performed \nusing the VITEK-2 compact system.\nResults: The prevalence of NTS among 1,08,468 samples was 0.056%. Most isolates were from stool \nsamples, followed by blood, pus, and urine. Most patients presented with acute gastroenteritis \n(56%), often associated with outside food consumption. S. Enteritidis and S. Typhimurium were \nthe most common serovars isolated. Extraintestinal manifestations included diabetic cellulitis, \nsepsis, and a rare case of generalized lymphadenopathy in a child, later diagnosed with Mendelian \nsusceptibility to mycobacterial diseases (MSMD), and a case of neonatal meningitis in a 15-day\nold infant. All isolates were susceptible to piperacillin-tazobactam, imipenem, and meropenem \n(100%). However, resistance to ceftriaxone was 22.9%, ciprofloxacin 31.1%, ampicillin 14.7% and \ntrimethoprim-sulfamethoxazole 3.27%.\nConclusion: Nontyphoidal Salmonella continues to pose a public health threat in India, particularly \nwith the rise of antimicrobial resistance. These findings underscore the importance of prudent \nantibiotic usage, robust surveillance systems, and public health interventions focused on food \nsafety, sanitation, and targeted education.<\/jats:p>","DOI":"10.59556\/japi.73.1248","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T11:47:56Z","timestamp":1766058476000},"page":"e6-e9","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence and Antimicrobial Resistance of Nontyphoidal  Salmonellosis in a Tertiary Care Hospital in South India"],"prefix":"10.59556","volume":"73","author":[{"given":"Srividhya","family":"M","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Fathima M","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathesini Priya","family":"AS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vithiya","family":"Ganesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Arunagiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendran","family":"T","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2914","published-online":{"date-parts":[[2025,11,10]]},"container-title":["Journal of the Association of Physicians of India"],"original-title":[],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T11:47:59Z","timestamp":1766058479000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.japi.org\/article\/japi-73-11-e6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,10]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,10]]},"published-print":{"date-parts":[[2025,11,10]]}},"URL":"https:\/\/doi.org\/10.59556\/japi.73.1248","relation":{},"ISSN":["0004-5772"],"issn-type":[{"value":"0004-5772","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,10]]}}}