{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:54:55Z","timestamp":1790456095460,"version":"4.1.0"},"reference-count":0,"publisher":"Jaypee Brothers Medical Publishing","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPI"],"published-print":{"date-parts":[[2025,11,10]]},"abstract":"<jats:p>Background: Among liver disorders, nonalcoholic fatty liver disease (NAFLD) is the most common \nand is associated with metabolic syndromes, particularly type 2 diabetes mellitus (T2DM). This \nstudy aimed to assess the effectiveness of pioglitazone in the management of T2DM with NAFLD.\nMethods: This retrospective, single-center, observational study was carried out at Dr Panikar\u2019s \nSpeciality Care Centre from 1st September 2022 to 1st February 2024. The data were collected \nfrom the medical records of diabetic patients with NAFLD who received pioglitazone. Patients \naged between 18 and 80 years who had diabetes along with NAFLD were included in the study.\nResults: A total of 3,350 patients were enrolled in this study, of whom 2,074 were male, with \na mean age of 48.6 years. The mean estimated A1C (eA1C) showed a significant reduction at  \n6 months compared to baseline (6.87 vs 7.6%; mean difference (95% CI): 0.50% (0.39, 0.61);  \np &lt; 0.001). At baseline, the mean controlled attenuation parameter (CAP) was significantly higher \nthan at 6 months (p = 0.032). Similarly, the mean cholesterol level was significantly higher at \nbaseline compared to 6 months (p = 0.020). A 25.7% decrease in grade 3 fatty liver was noted over \nthe 6-month period from baseline. In terms of the decrease in fibrosis severity, a 37.5% reduction in \nF2, a 25.8% reduction in F1, and a 17.6% reduction in F4 were observed from baseline to 6 months.\nConclusion: In T2DM patients with NAFLD, pioglitazone improves glycemic control and reduces \nboth fatty liver grades and fibrosis stages.<\/jats:p>","DOI":"10.59556\/japi.73.1250","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T10:06:42Z","timestamp":1766052402000},"page":"17-19","source":"Crossref","is-referenced-by-count":3,"title":["Evaluating Pioglitazone for Managing Type 2 Diabetes  Mellitus in Patients with Nonalcoholic Fatty Liver Disease"],"prefix":"10.59556","volume":"73","author":[{"given":"Vijay","family":"Panikar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apoorva","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Nasikkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashank","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanhita","family":"Walwalkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishita","family":"Sachdev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mangesh","family":"Tiwaskar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krish","family":"Panikar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Mahajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayan","family":"Deogaonkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimit","family":"Vadgama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshpreet","family":"Tuteja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Lalwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samiksha","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parveen","family":"Kader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2914","published-online":{"date-parts":[[2025,11,10]]},"container-title":["Journal of the Association of Physicians of India"],"original-title":[],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T10:06:42Z","timestamp":1766052402000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.japi.org\/article\/japi-73-11-17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,10]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,10]]},"published-print":{"date-parts":[[2025,11,10]]}},"URL":"https:\/\/doi.org\/10.59556\/japi.73.1250","relation":{},"ISSN":["0004-5772"],"issn-type":[{"value":"0004-5772","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,10]]}}}