{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:44:36Z","timestamp":1779205476582,"version":"3.51.4"},"reference-count":0,"publisher":"Jaypee Brothers Medical Publishing","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPI"],"published-print":{"date-parts":[[2025,11,10]]},"abstract":"<jats:p>Background: Hypokalemic paralysis is a rare but potentially life-threatening neuromuscular \nemergency characterized by the sudden onset of flaccid weakness due to reduced serum \npotassium. While inherited channelopathies represent primary causes, secondary etiologies\u2014\nparticularly endocrine, renal, and metabolic disorders\u2014are more frequently encountered and \nrequire timely recognition to avoid complications.\nCase summary: We report four patients presenting with acute flaccid paralysis associated with \ndocumented hypokalemia (serum potassium &lt;3.5 mmol\/L). The first case involved a pregnant \nwoman with primary hyperaldosteronism due to an adrenal adenoma, managed initially with \nspironolactone and subsequently cured by adrenalectomy. The second case was a normotensive \nfemale diagnosed with distal renal tubular acidosis (dRTA) in the setting of Sj\u00f6gren\u2019s syndrome, \ntreated with potassium citrate and sodium bicarbonate. The third case was a young male with \nthyrotoxic periodic paralysis (TPP) secondary to Graves\u2019 disease, who improved with antithyroid \ndrugs and beta-blockers. The fourth case described a young male with primary hypokalemic \nperiodic paralysis (HPP), presenting with exertion-induced weakness, successfully treated with \nintravenous potassium supplementation.\nConclusion: This case series underscores the diverse etiologies of hypokalemic paralysis, spanning \nendocrine, renal, autoimmune, and genetic causes. A systematic diagnostic approach, guided by \nclinical and biochemical evaluation, is essential for timely treatment. Identifying the underlying \ncause not only ensures effective acute management but also prevents recurrence and reduces \nthe risk of serious complications, including cardiac arrhythmias.<\/jats:p>","DOI":"10.59556\/japi.73.1253","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:17:13Z","timestamp":1766049433000},"page":"62-66","source":"Crossref","is-referenced-by-count":1,"title":["Exploring Etiologies of Hypokalemic Paralysis: A Case Series"],"prefix":"10.59556","volume":"73","author":[{"given":"Shyam C","family":"Chaudhary","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shambhavi","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarun","family":"Pal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal K","family":"Sawlani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2914","published-online":{"date-parts":[[2025,11,10]]},"container-title":["Journal of the Association of Physicians of India"],"original-title":[],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:17:29Z","timestamp":1766049449000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.japi.org\/article\/japi-73-11-s1-62"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,10]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,10]]},"published-print":{"date-parts":[[2025,11,10]]}},"URL":"https:\/\/doi.org\/10.59556\/japi.73.1253","relation":{},"ISSN":["0004-5772"],"issn-type":[{"value":"0004-5772","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,10]]}}}