{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T09:25:05Z","timestamp":1766395505526,"version":"3.48.0"},"reference-count":0,"publisher":"Jaypee Brothers Medical Publishing","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPI"],"published-print":{"date-parts":[[2025,12,10]]},"abstract":"<jats:p>Background: Traditional lipid parameters like low-density lipoprotein (LDL), high-density \nlipoprotein (HDL), and total cholesterol (TC) are commonly used in evaluating cardiovascular risk. \nRecently, emerging biomarkers such as apolipoprotein B (ApoB) and apolipoprotein A1 (ApoA1) \nare proposed to provide improved accuracy in assessing atherosclerotic risk. This study examined \nthe association between conventional and novel lipid parameters and plaque burden in statin\nna\u00efve acute coronary syndrome (ACS) patients.\nMethodology: We enrolled 81 statin-na\u00efve patients with ACS. Each underwent both standard \nand extended lipid profiling. Coronary angiograms were evaluated using the Gensini score to \nquantify plaque burden. All participants were followed for 28 days to monitor for major adverse \ncardiac events (MACE).\nResults: The average age was 51 years, with males comprising 77%. The ST-segment elevation \nmyocardial infarction (STEMI) was observed in 58% of cases, non-ST-segment elevation myocardial \ninfarction (NSTEMI) in 31%, and unstable angina in 11%. There was a significant correlation between \nthe Gensini score and TC\/HDL ratio (r = 0.35), LDL\/HDL ratio (r = 0.31), and ApoB levels (r = 0.24). \nLDL and the ApoB\/ApoA1 ratio did not exhibit significant associations with plaque burden. STEMI \npatients had higher LDL\/HDL and TC\/HDL ratios compared to those with NSTEMI or unstable \nangina. MACE occurred in 16% of participants, with no significant difference across ACS subtypes.\nConclusion: The ratios of TC\/HDL, LDL\/HDL, and ApoB levels were positively associated \nwith coronary plaque burden. While conventional lipid parameters continue to serve well in \ncardiovascular risk assessment (CRA), ApoB presents a promising standalone marker for identifying \natherogenic risk and may serve as a practical alternative in clinical practice.<\/jats:p>","DOI":"10.59556\/japi.73.1272","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T09:22:21Z","timestamp":1766395341000},"page":"27-32","source":"Crossref","is-referenced-by-count":0,"title":["Correlation of Conventional and Extended Lipid Profiles with  Plaque Burden in Statin-na\u00efve Patients with Acute Coronary  Syndrome: A Prospective Observational Study from South  India"],"prefix":"10.59556","volume":"73","author":[{"given":"Mughilan","family":"Periasamy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramu","family":"Ramadoss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avinash","family":"Anantharaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balasubramaniyan","family":"Vairappan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2914","published-online":{"date-parts":[[2025,12,10]]},"container-title":["Journal of the Association of Physicians of India"],"original-title":[],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T09:22:22Z","timestamp":1766395342000},"score":1,"resource":{"primary":{"URL":"https:\/\/japi.org\/article\/japi-73-12-27"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,10]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12,10]]},"published-print":{"date-parts":[[2025,12,10]]}},"URL":"https:\/\/doi.org\/10.59556\/japi.73.1272","relation":{},"ISSN":["0004-5772"],"issn-type":[{"value":"0004-5772","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,10]]}}}