{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T09:25:04Z","timestamp":1766395504609,"version":"3.48.0"},"reference-count":0,"publisher":"Jaypee Brothers Medical Publishing","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAPI"],"published-print":{"date-parts":[[2025,12,10]]},"abstract":"<jats:p>Introduction: Cardiac dysfunction is one of the major causes of mortality in patients with sepsis. \nThe acute physiology and chronic health evaluation II (APACHE II), quick sequential organ failure \nassessment (qSOFA), and other prognostic scores for sepsis have established data regarding their \naccuracy in predicting mortality. We have assessed the prognostic role of cardiac biomarkers \n[creatine phosphokinase-myocardial band (CPK-MB), troponin I (Trop I), and probrain natriuretic \npeptide (proBNP)] in patients with sepsis and compared it with the APACHE II score.\nMaterials and methods: A total of 126 patients (63 in each group) participated in this case\u2013control \nstudy in a large tertiary care teaching hospital. Patients with sepsis who required hospitalization \nwere enrolled in the case group and compared with another group of nonsepticemic patients. \nThey were taken for detailed evaluation and investigation on day 1 and day 3. Our study included \nproBNP, CPK-MB, Trop I, and APACHE II score.\nResults: Both the case and control groups comprised 63 patients each. It was observed that the \ncardiac biomarkers (proBNP, Trop I, CPK-MB) were markedly higher among cases than in controls. \nSimilarly, these markers were also found markedly higher in fatal cases than survivors in the case \ngroup. Out of all three biomarkers, proBNP was correlated well with mortality as much as the \nAPACHE II score. It was also observed that increasing trends in the levels of biomarkers depict \nprognosis more effectively than a single value. Conclusion: We conclude that cardiac biomarkers can be routinely used as dynamic markers for the \nprediction of mortality and prognosis in patients with sepsis. ProBNP may be useful in predicting \nmortality in patients with sepsis.<\/jats:p>","DOI":"10.59556\/japi.73.1274","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T09:22:21Z","timestamp":1766395341000},"page":"23-26","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Assessment of Cardiac Biomarkers and APACHE  II Score for Prognostication in Septicemic Patients at a Tertiary  Care Hospital"],"prefix":"10.59556","volume":"73","author":[{"given":"Shefali","family":"Meena","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CL","family":"Nawal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazari L","family":"Saini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radhey S","family":"Chejara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aradhana","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2914","published-online":{"date-parts":[[2025,12,10]]},"container-title":["Journal of the Association of Physicians of India"],"original-title":[],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T09:22:21Z","timestamp":1766395341000},"score":1,"resource":{"primary":{"URL":"https:\/\/japi.org\/article\/japi-73-12-23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,10]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12,10]]},"published-print":{"date-parts":[[2025,12,10]]}},"URL":"https:\/\/doi.org\/10.59556\/japi.73.1274","relation":{},"ISSN":["0004-5772"],"issn-type":[{"value":"0004-5772","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,10]]}}}