{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:53:15Z","timestamp":1791237195651,"version":"4.1.0"},"reference-count":16,"publisher":"Jaypee Brothers Medical Publishing","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.59556\/japi.74.1293","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T05:18:24Z","timestamp":1771823904000},"page":"11-14","source":"Crossref","is-referenced-by-count":1,"title":["Mineralocorticoid Receptor Antagonists: An Overview of History and Evolution"],"prefix":"10.59556","volume":"74","author":[{"given":"BC","family":"Kalmath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mangesh","family":"Tiwaskar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gattu R","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemant","family":"Khemani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev","family":"Kishore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Chouhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harikrishnan","family":"BL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarita","family":"Choudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Febin","family":"Francis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarnath","family":"Sugumaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senthilnathan","family":"Mohanasundaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2914","reference":[{"key":"key20260223051941_B1","doi-asserted-by":"crossref","first-page":"78\u2013","DOI":"10.1016\/j.coph.2016.02.005","article-title":"Mineralocorticoid receptor antagonists\u2014pharmacodynamics and pharmacokinetic differences.","volume":"27:","author":"Yang","year":"2016;","journal-title":"Curr Opin Pharmacol"},{"issue":"(2):","key":"key20260223051941_B2","doi-asserted-by":"crossref","first-page":"152\u2013","DOI":"10.1093\/eurheartj\/ehaa736","article-title":"Steroidal and non-steroidal mineralocorticoid receptor antagonists in cardiorenal medicine.","volume":"42","author":"Agarwal","year":"2021;","journal-title":"Eur Heart J"},{"issue":"(1):","key":"key20260223051941_B3","doi-asserted-by":"crossref","first-page":"T125\u2013","DOI":"10.1530\/JOE-16-0600","article-title":"30 years of the mineralocorticoid receptor: mineralocorticoid receptor antagonists: 60 years of research and development.","volume":"234","author":"Kolkhof","year":"2017;","journal-title":"J Endocrinol"},{"issue":"(16):","key":"key20260223051941_B4","doi-asserted-by":"crossref","first-page":"9088.","DOI":"10.3390\/ijms25169088","article-title":"Clinical properties and non-clinical testing of mineralocorticoid receptor antagonists in in vitro cell models.","volume":"25","author":"Varda","year":"2024;","journal-title":"Int J Mol Sci"},{"key":"key20260223051941_B5","doi-asserted-by":"crossref","first-page":"129.","DOI":"10.2147\/IBPC.S13783","article-title":"Mineralocorticoid receptor antagonists: emerging roles in cardiovascular medicine.","author":"Funder","year":"2013:","journal-title":"Integr Blood Press Control"},{"issue":"(1):","key":"key20260223051941_B6","doi-asserted-by":"crossref","first-page":"159.","DOI":"10.1186\/s43044-024-00586-z","article-title":"Finerenone: a breakthrough mineralocorticoid receptor antagonist for heart failure, diabetes and chronic kidney disease.","volume":"76","author":"Pradhan","year":"2024;","journal-title":"Egypt Heart J"},{"issue":"(13):","key":"key20260223051941_B7","doi-asserted-by":"crossref","first-page":"3235\u2013","DOI":"10.1111\/bph.15719","article-title":"Approaches towards tissue-selective pharmacology of the mineralocorticoid receptor.","volume":"179","author":"Clarisse","year":"2022;","journal-title":"Br J Pharmacol"},{"key":"key20260223051941_B8","doi-asserted-by":"crossref","unstructured":"Sethi R, Vishwakarma P, Pradhan A. Evidence for Aldosterone Antagonism in Heart Failure. Published online August 12, 2024. Accessed April 24, 2025. https:\/\/www.cfrjournal.com\/articles\/evidence-aldosterone-antagonism-heart-failure?language_content_entity=en","DOI":"10.15420\/cfr.2024.10"},{"issue":"(1-2):","key":"key20260223051941_B9","doi-asserted-by":"crossref","first-page":"27\u2013","DOI":"10.1016\/j.mce.2003.10.005","article-title":"The evolution of aldosterone antagonists.","volume":"217","author":"Garthwaite","year":"2004;","journal-title":"Mol Cell Endocrinol"},{"issue":"(11):","key":"key20260223051941_B10","doi-asserted-by":"crossref","first-page":"1141\u2013","DOI":"10.1080\/13543784.2021.2002844","article-title":"Differentiation between emerging non-steroidal and established steroidal mineralocorticoid receptor antagonists: head-to-head comparisons of pharmacological and clinical characteristics.","volume":"30","author":"Barrera-Chimal","year":"2021;","journal-title":"Expert Opin Investig Drugs"},{"issue":"(13):","key":"key20260223051941_B11","doi-asserted-by":"crossref","first-page":"3220\u2013","DOI":"10.1111\/bph.15747","article-title":"Novel non-steroidal mineralocorticoid receptor antagonists in cardiorenal disease.","volume":"179","author":"Kintscher","year":"2022;","journal-title":"Br J Pharmacol"},{"issue":"(1):","key":"key20260223051941_B12","doi-asserted-by":"crossref","first-page":"162.","DOI":"10.1186\/s12933-023-01899-0","article-title":"The non-steroidal mineralocorticoid receptor antagonist finerenone and heart failure with preserved ejection fraction.","volume":"22","author":"Kintscher","year":"2023;","journal-title":"Cardiovasc Diabetol"},{"issue":"(31):","key":"key20260223051941_B13","doi-asserted-by":"crossref","first-page":"2931\u2013","DOI":"10.1093\/eurheartj\/ehac299","article-title":"Non-steroidal mineralocorticoid receptor antagonists in cardiorenal disease.","volume":"43","author":"Pandey","year":"2022;","journal-title":"Eur Heart J"},{"issue":"(10458):","key":"key20260223051941_B14","doi-asserted-by":"crossref","first-page":"1119\u2013","DOI":"10.1016\/S0140-6736(24)01733-1","article-title":"Mineralocorticoid receptor antagonists in heart failure: an individual patient level meta-analysis.","volume":"404","author":"Jhund","year":"2024;","journal-title":"Lancet"},{"issue":"(1):","key":"key20260223051941_B15","doi-asserted-by":"crossref","first-page":"sfae346.","DOI":"10.1093\/ckj\/sfae346","article-title":"Clinical implications of mineralocorticoid receptor overactivation.","volume":"18","author":"El Mouhayyar","year":"2025;","journal-title":"Clin Kidney J"},{"issue":"(Suppl_1):","key":"key20260223051941_B16","doi-asserted-by":"crossref","first-page":"i29\u2013","DOI":"10.1093\/ndt\/gfae241","article-title":"Mineralocorticoid receptor antagonism for non-diabetic kidney disease.","volume":"40","author":"Jaisser","year":"2025;","journal-title":"Nephrol Dial Transplant"}],"container-title":["Journal of The Association of Physicians of India"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T05:19:48Z","timestamp":1771823988000},"score":1,"resource":{"primary":{"URL":"https:\/\/japi.org\/article\/japi-74-1-s1-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.59556\/japi.74.1293"],"URL":"https:\/\/doi.org\/10.59556\/japi.74.1293","relation":{},"ISSN":["0004-5772"],"issn-type":[{"value":"0004-5772","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}