{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:27:49Z","timestamp":1790800069797,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T00:00:00Z","timestamp":1433894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100012443","name":"Maryland Stem Cell Research Fund","doi-asserted-by":"crossref","award":["2009-MSCRFII-0082-00"],"award-info":[{"award-number":["2009-MSCRFII-0082-00"]}],"id":[{"id":"10.13039\/100012443","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012443","name":"Maryland Stem Cell Research Fund","doi-asserted-by":"crossref","award":["2007-MSCRFE-0110-00"],"award-info":[{"award-number":["2007-MSCRFE-0110-00"]}],"id":[{"id":"10.13039\/100012443","id-type":"DOI","asserted-by":"crossref"}]},{"name":"R.A.F","award":["2011-MSCRF II-0008-00"],"award-info":[{"award-number":["2011-MSCRF II-0008-00"]}]},{"name":"R.A.F","award":["2007-MSCRFII-0379-00"],"award-info":[{"award-number":["2007-MSCRFII-0379-00"]}]},{"DOI":"10.13039\/100000912","name":"March of Dimes","doi-asserted-by":"crossref","award":["Grant 6-FY10-334"],"award-info":[{"award-number":["Grant 6-FY10-334"]}],"id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"NIH\/National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["U01HL099775"],"award-info":[{"award-number":["U01HL099775"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title\/><jats:p>Gaucher disease (GD) is the most common lysosomal storage disease resulting from mutations in the lysosomal enzyme glucocerebrosidase (GCase). The hematopoietic abnormalities in GD include the presence of characteristic Gaucher macrophages that infiltrate patient tissues and cytopenias. At present, it is not clear whether these cytopenias are secondary to the pathological activity of Gaucher cells or a direct effect of GCase deficiency on hematopoietic development. To address this question, we differentiated induced pluripotent stem cells (iPSCs) derived from patients with types 1, 2, and 3 GD to CD34+\/CD45+\/CD43+\/CD143+ hematopoietic progenitor cells (HPCs) and examined their developmental potential. The formation of GD-HPCs was unaffected. However, these progenitors demonstrated a skewed lineage commitment, with increased myeloid differentiation and decreased erythroid differentiation and maturation. Interestingly, myeloid colony-formation assays revealed that GD-HPCs, but not control-HPCs, gave rise to adherent, macrophage-like cells, another indication of abnormal myelopoiesis. The extent of these hematologic abnormalities correlated with the severity of the GCase mutations. All the phenotypic abnormalities of GD-HPCs observed were reversed by incubation with recombinant GCase, indicating that these developmental defects were caused by the mutated GCase. Our results show that GCase deficiency directly impairs hematopoietic development. Additionally, our results suggest that aberrant myelopoiesis might contribute to the pathological properties of Gaucher macrophages, which are central to GD manifestations. The hematopoietic developmental defects we observed reflect hematologic abnormalities in patients with GD, demonstrating the utility of GD-iPSCs for modeling this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This study showed that hematopoietic progenitors from patients with Gaucher disease (GD) have intrinsic developmental abnormalities that reflect characteristic clinical manifestations. These abnormalities include decreased erythroid potential and abnormal myelopoiesis. GD hematopoietic progenitors gave rise to aberrant macrophage-like cells, suggesting that abnormal myelopoiesis may contribute to the pathological properties of Gaucher macrophages. All the hematopoietic abnormalities observed were reversed by incubation with recombinant glucocerebrosidase, which is used to treat patients with type 1 GD. The results suggest that enzyme replacement therapy could help normalize clinical parameters in these patients, not only through recombinant glucocerebrosidase uptake by Gaucher macrophages, which are the intended target, but also potentially by acting directly on hematopoietic progenitors. The results shown here provide new insights into the etiology of GD hematopoietic abnormalities, and highlight the utility of GD iPSC for modeling the disease and therapeutic development.<\/jats:p><\/jats:sec>","DOI":"10.5966\/sctm.2014-0213","type":"journal-article","created":{"date-parts":[[2015,6,11]],"date-time":"2015-06-11T02:14:43Z","timestamp":1433988883000},"page":"878-886","source":"Crossref","is-referenced-by-count":26,"title":["Gaucher Disease-Induced Pluripotent Stem Cells Display Decreased Erythroid Potential and Aberrant Myelopoiesis"],"prefix":"10.1093","volume":"4","author":[{"given":"Judi A.","family":"Sgambato","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tea Soon","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leelamma M.","family":"Panicker","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Sidransky","sequence":"additional","affiliation":[{"name":"Medical Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Lun","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Awad","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren M.","family":"Bentzen","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Bioinformatics, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias T.","family":"Zambidis","sequence":"additional","affiliation":[{"name":"Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo A.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Maryland School of Medicine, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,6,10]]},"reference":[{"key":"2021122704330841300_R1","doi-asserted-by":"crossref","first-page":"20423","DOI":"10.1074\/jbc.R110.134452","article-title":"Common and uncommon pathogenic cascades in lysosomal storage diseases","volume":"285","author":"Vitner","year":"2010","journal-title":"J Biol Chem"},{"key":"2021122704330841300_R2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1615\/CritRevOncog.2013006060","article-title":"Gaucher disease: A comprehensive review","volume":"18","author":"Rosenbloom","year":"2013","journal-title":"Crit Rev Oncog"},{"key":"2021122704330841300_R3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1182\/asheducation.V2012.1.13.3797921","article-title":"Gaucher disease and other storage disorders","volume":"2012","author":"Grabowski","year":"2012","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"2021122704330841300_R4","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1365-2141.2004.05351.x","article-title":"Gaucher disease: Pathological mechanisms and modern management","volume":"129","author":"Jmoudiak","year":"2005","journal-title":"Br J Haematol"},{"key":"2021122704330841300_R5","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1007\/s00018-002-8458-y","article-title":"Gaucher disease: Perspectives on a prototype lysosomal disease","volume":"59","author":"Zhao","year":"2002","journal-title":"Cell Mol Life Sci"},{"key":"2021122704330841300_R6","first-page":"151","article-title":"Pathology of the Gaucher cell","volume":"95","author":"Parkin","year":"1982","journal-title":"Prog Clin Biol Res"},{"key":"2021122704330841300_R7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1309\/BG5VA8JRDQH1M7HN","article-title":"Gaucher cells demonstrate a distinct macrophage phenotype and resemble alternatively activated macrophages","volume":"122","author":"Boven","year":"2004","journal-title":"Am J Clin Pathol"},{"key":"2021122704330841300_R8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10545-010-9241-0","article-title":"Gaucher disease with foamy transformed macrophages and erythrophagocytic activity","volume":"34","author":"Machaczka","year":"2011","journal-title":"J Inherit Metab Dis"},{"key":"2021122704330841300_R9","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.5858\/2004-128-1191-EIGC","article-title":"Erythrophagocytosis in Gaucher cells","volume":"128","author":"Bitton","year":"2004","journal-title":"Arch Pathol Lab Med"},{"key":"2021122704330841300_R10","doi-asserted-by":"crossref","first-page":"18054","DOI":"10.1073\/pnas.1207889109","article-title":"Induced pluripotent stem cell model recapitulates pathologic hallmarks of Gaucher disease","volume":"109","author":"Panicker","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021122704330841300_R11","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1365-2141.2007.06701.x","article-title":"Recommendations for the management of the haematological and onco-haematological aspects of Gaucher disease","volume":"138","author":"Hughes","year":"2007","journal-title":"Br J Haematol"},{"key":"2021122704330841300_R12","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/bjh.12804","article-title":"Gaucher disease: Haematological presentations and complications","volume":"165","author":"Thomas","year":"2014","journal-title":"Br J Haematol"},{"key":"2021122704330841300_R13","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/cyto.b.20539","article-title":"A cytometric study of the red blood cells in Gaucher disease reveals their abnormal shape that may be involved in increased erythrophagocytosis","volume":"80","author":"Bratosin","year":"2011","journal-title":"Cytometry B Clin Cytom"},{"key":"2021122704330841300_R14","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1182\/blood-2012-07-442467","article-title":"Abnormal properties of red blood cells suggest a role in the pathophysiology of Gaucher disease","volume":"121","author":"Franco","year":"2013","journal-title":"Blood"},{"key":"2021122704330841300_R15","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1365-2141.2006.06199.x","article-title":"Aggregation of red blood cells in patients with Gaucher disease","volume":"134","author":"Adar","year":"2006","journal-title":"Br J Haematol"},{"key":"2021122704330841300_R16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1615\/CritRevOncog.2013006061","article-title":"Gaucher disease and myeloma","volume":"18","author":"Ayto","year":"2013","journal-title":"Crit Rev Oncog"},{"key":"2021122704330841300_R17","first-page":"205","article-title":"Cytokines in Gaucher's disease","volume":"10","author":"Barak","year":"1999","journal-title":"Eur Cytokine Netw"},{"key":"2021122704330841300_R18","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1002\/stem.1732","article-title":"Gaucher iPSC-derived macrophages produce elevated levels of inflammatory mediators and serve as a new platform for therapeutic development","volume":"32","author":"Panicker","year":"2014","journal-title":"Stem Cells"},{"key":"2021122704330841300_R19","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"2021122704330841300_R20","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"2021122704330841300_R21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1146\/annurev-med-050311-163324","article-title":"Reprogrammed cells for disease modeling and regenerative medicine","volume":"64","author":"Cherry","year":"2013","journal-title":"Annu Rev Med"},{"key":"2021122704330841300_R22","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.cell.2012.02.031","article-title":"Reprogramming cellular identity for regenerative medicine","volume":"148","author":"Cherry","year":"2012","journal-title":"Cell"},{"key":"2021122704330841300_R23","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1177\/1947601911401908","article-title":"Tinkering with transcription factors uncovers plasticity of somatic cells","volume":"1","author":"Azevedo","year":"2010","journal-title":"Genes Cancer"},{"key":"2021122704330841300_R24","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.drudis.2014.01.004","article-title":"Induced pluripotent stem cell-derived myeloid phagocytes: Disease modeling and therapeutic applications","volume":"19","author":"Goodridge","year":"2014","journal-title":"Drug Discov Today"},{"key":"2021122704330841300_R25","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1093\/nar\/25.18.3745","article-title":"A transgenic mouse strain expressing four drug-selectable marker genes","volume":"25","author":"Tucker","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"2021122704330841300_R26","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/cyto.a.22090","article-title":"Efficient and simultaneous generation of hematopoietic and vascular progenitors from human induced pluripotent stem cells","volume":"83","author":"Park","year":"2013","journal-title":"Cytometry A"},{"key":"2021122704330841300_R27","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1182\/blood-2008-03-144766","article-title":"Expression of angiotensin-converting enzyme (CD143) identifies and regulates primitive hemangioblasts derived from human pluripotent stem cells","volume":"112","author":"Zambidis","year":"2008","journal-title":"Blood"},{"key":"2021122704330841300_R28","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s11626-010-9337-8","article-title":"Characterization of human embryonic stem cell-derived hematopoietic progenitor phenotype","volume":"46","author":"Zhou","year":"2010","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"2021122704330841300_R29","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1182\/blood-2006-02-003327","article-title":"Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures","volume":"108","author":"Vodyanik","year":"2006","journal-title":"Blood"},{"key":"2021122704330841300_R30","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1309\/AJCPCRK3MOAOJ6AT","article-title":"CD71 (transferrin receptor): An effective marker for erythroid precursors in bone marrow biopsy specimens","volume":"134","author":"Marsee","year":"2010","journal-title":"Am J Clin Pathol"},{"key":"2021122704330841300_R31","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.3324\/haematol.2009.019828","article-title":"The majority of the in vitro erythroid expansion potential resides in CD34(\u2212) cells, outweighing the contribution of CD34(+) cells and significantly increasing the erythroblast yield from peripheral blood samples","volume":"95","author":"van den Akker","year":"2010","journal-title":"Haematologica"},{"key":"2021122704330841300_R32","doi-asserted-by":"crossref","first-page":"17413","DOI":"10.1073\/pnas.0909296106","article-title":"Resolving the distinct stages in erythroid differentiation based on dynamic changes in membrane protein expression during erythropoiesis","volume":"106","author":"Chen","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021122704330841300_R33","first-page":"299","article-title":"Gaucher disease: Clinical profile and therapeutic developments","volume":"4","author":"Cox","year":"2010","journal-title":"Biologics"},{"key":"2021122704330841300_R34","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ymgme.2006.09.007","article-title":"Therapy for Gaucher disease: Don't stop thinking about tomorrow","volume":"90","author":"Sidransky","year":"2007","journal-title":"Mol Genet Metab"},{"key":"2021122704330841300_R35","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2141.2010.08214.x","article-title":"Glucocerebrosidase deficiency dramatically impairs human bone marrow haematopoiesis in an in vitro model of Gaucher disease","volume":"150","author":"Berger","year":"2010","journal-title":"Br J Haematol"},{"key":"2021122704330841300_R36","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/s10354-010-0864-4","article-title":"The pathophysiology of GD\u2014Current understanding and rationale for existing and emerging therapeutic approaches","volume":"160","author":"Hughes","year":"2010","journal-title":"Wien Med Wochenschr"},{"key":"2021122704330841300_R37","doi-asserted-by":"crossref","first-page":"13819","DOI":"10.1073\/pnas.0606016103","article-title":"Effective cell and gene therapy in a murine model of Gaucher disease","volume":"103","author":"Enquist","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021122704330841300_R38","doi-asserted-by":"crossref","first-page":"19473","DOI":"10.1073\/pnas.1003308107","article-title":"Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage","volume":"107","author":"Mistry","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021122704330841300_R39","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/path.4227","article-title":"B cell lymphoma and myeloma in murine Gaucher's disease","volume":"231","author":"Pavlova","year":"2013","journal-title":"J Pathol"},{"key":"2021122704330841300_R40","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1203\/00006450-200008000-00018","article-title":"Glucosylsphingosine accumulation in mice and patients with type 2 Gaucher disease begins early in gestation","volume":"48","author":"Orvisky","year":"2000","journal-title":"Pediatr Res"},{"key":"2021122704330841300_R41","volume-title":"Atlas of Human Hematopoietic Colonies","author":"Eaves","year":"1995"},{"key":"2021122704330841300_R42","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1182\/blood-2013-07-474825","article-title":"Hematopoietic specification from human pluripotent stem cells: Current advances and challenges toward de novo generation of hematopoietic stem cells","volume":"122","author":"Slukvin","year":"2013","journal-title":"Blood"},{"key":"2021122704330841300_R43","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1101\/sqb.2008.73.031","article-title":"Establishment of a normal hematopoietic and leukemia stem cell hierarchy","volume":"73","author":"Chao","year":"2008","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"2021122704330841300_R44","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2302\/kjm.60.47","article-title":"Role of transcription factors in differentiation and reprogramming of hematopoietic cells","volume":"60","author":"Nakajima","year":"2011","journal-title":"Keio J Med"},{"key":"2021122704330841300_R45","doi-asserted-by":"crossref","first-page":"270425","DOI":"10.1155\/2012\/270425","article-title":"Hematopoietic stem cell development, niches, and signaling pathways","volume":"2012","author":"Chotinantakul","year":"2012","journal-title":"Bone Marrow Res"},{"key":"2021122704330841300_R46","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev.med.57.110104.115650","article-title":"Enzyme replacement for lysosomal diseases","volume":"57","author":"Brady","year":"2006","journal-title":"Annu Rev Med"},{"key":"2021122704330841300_R47","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/humu.20676","article-title":"Gaucher disease: Mutation and polymorphism spectrum in the glucocerebrosidase gene (GBA)","volume":"29","author":"Hruska","year":"2008","journal-title":"Hum Mutat"},{"key":"2021122704330841300_R48","doi-asserted-by":"crossref","first-page":"851","DOI":"10.5858\/2008-132-851-GDROTL","article-title":"Gaucher disease: Review of the literature","volume":"132","author":"Chen","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"2021122704330841300_R49","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1086\/302925","article-title":"Analysis and classification of 304 mutant alleles in patients with type 1 and type 3 Gaucher disease","volume":"66","author":"Koprivica","year":"2000","journal-title":"Am J Hum Genet"}],"container-title":["Stem Cells Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.5966%2Fsctm.2014-0213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.5966%2Fsctm.2014-0213","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/4\/8\/878\/41864173\/stcltm_4_8_878.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/stcltm\/article-pdf\/4\/8\/878\/41864173\/stcltm_4_8_878.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T12:32:56Z","timestamp":1717936376000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/stcltm\/article\/4\/8\/878-886\/6397309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,10]]},"references-count":49,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,6,10]]},"published-print":{"date-parts":[[2015,8,1]]}},"URL":"https:\/\/doi.org\/10.5966\/sctm.2014-0213","relation":{},"ISSN":["2157-6564","2157-6580"],"issn-type":[{"value":"2157-6564","type":"print"},{"value":"2157-6580","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,8,1]]},"published":{"date-parts":[[2015,6,10]]}}}