{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:59:53Z","timestamp":1791165593491,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2015,4,29]],"date-time":"2015-04-29T00:00:00Z","timestamp":1430265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Spanish Ministry of Health and Consumer Affairs","award":["EC10-343"],"award-info":[{"award-number":["EC10-343"]}]},{"name":"Spanish Ministry of Health and Consumer Affairs","award":["RD12\/0019\/0035"],"award-info":[{"award-number":["RD12\/0019\/0035"]}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"crossref","award":["S2010\/BMD-2420"],"award-info":[{"award-number":["S2010\/BMD-2420"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title\/>\n                  <jats:p>The aim of this study was to determine whether treatment with adipose-derived stem cells (ASCs) had any influence on fertility, course of pregnancy, newborn weight, or physical condition of newborns. We performed a retrospective study of patients with a desire to become pregnant after having received intralesional injection of autologous ASCs for the treatment of perianal or rectovaginal fistula associated with Crohn's disease. We collected data on the resulting pregnancies, deliveries, and newborns of these patients. ASCs were expanded in vitro and characterized according to the international guidelines for cell surface markers (clusters of differentiation) and differentiated to adipocytes, chondrocytes, and osteocytes prior to implantation (except first implant in 2002). We analyzed five young women with Crohn's disease treated with ASCs: one for rectovaginal and perianal fistula, two for rectovaginal fistula only, and two for perianal fistula only. All patients received 2 doses of 20 million and 40 million cells at an interval of 3\u20134 months. Another patient received 2 doses of 6.6 million and 20 million ASCs with 9 months between each dose. Fertility and pregnancy outcomes were not affected by cell therapy treatment. No signs of treatment-related malformations were observed in the neonates by their respective pediatricians. In the patients studied, cell therapy with ASCs did not affect the course of pregnancy or newborn development.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Significance<\/jats:title>\n                  <jats:p>Local treatment with mesenchymal stem cells derived from adipose tissue seems not to affect the ability to conceive, the course of pregnancy, pregnancy outcomes, or newborns' health in female patients. This is the first publication about pregnancy outcome in women with perianal fistula and Crohn's disease treated with stem cell therapy, and could be of interest for doctors working in cell therapy. This is a very important question for patients, and there was no answer for them until now.<\/jats:p>\n               <\/jats:sec>","DOI":"10.5966\/sctm.2014-0255","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T02:21:51Z","timestamp":1430360511000},"page":"598-602","source":"Crossref","is-referenced-by-count":31,"title":["First-in-Human Case Study: Pregnancy in Women With Crohn's Perianal Fistula Treated With Adipose-Derived Stem Cells: A Safety Study"],"prefix":"10.1093","volume":"4","author":[{"given":"Raquel","family":"Sanz-Baro","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, IIS-FJD Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Garc\u00eda-Arranz","sequence":"additional","affiliation":[{"name":"Surgery Department, Aut\u00f3noma University of Madrid, Madrid, Spain"},{"name":"Cell Therapy Laboratory, Health Research Institute, IIS-FJD Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Guadalajara","sequence":"additional","affiliation":[{"name":"Department of Surgery, IIS-FJD Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"de la Quintana","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, La Paz University Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Dolores","family":"Herreros","sequence":"additional","affiliation":[{"name":"Department of Surgery, IIS-FJD Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dami\u00e1n","family":"Garc\u00eda-Olmo","sequence":"additional","affiliation":[{"name":"Surgery Department, Aut\u00f3noma University of Madrid, Madrid, Spain"},{"name":"Department of Surgery, IIS-FJD Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,4,29]]},"reference":[{"key":"2021122704225290400_R1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. 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