{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:26:12Z","timestamp":1790749572544,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2015,9,14]],"date-time":"2015-09-14T00:00:00Z","timestamp":1442188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title\/>\n                  <jats:p>Rotator cuff tendon tear is one of the most common causes of chronic shoulder pain and disability. In this study, we investigated the therapeutic effects of ultrasound-guided human umbilical cord blood (UCB)-derived mesenchymal stem cell (MSC) injection to regenerate a full-thickness subscapularis tendon tear in a rabbit model by evaluating the gross morphology and histology of the injected tendon and motion analysis of the rabbit's activity. At 4 weeks after ultrasound-guided UCB-derived MSC injection, 7 of the 10 full-thickness subscapularis tendon tears were only partial-thickness tears, and 3 remained full-thickness tendon tears. The tendon tear size and walking capacity at 4 weeks after UCB-derived MSC injection under ultrasound guidance were significantly improved compared with the same parameters immediately after tendon tear. UCB-derived MSC injection under ultrasound guidance without surgical repair or bioscaffold resulted in the partial healing of full-thickness rotator cuff tendon tears in a rabbit model. Histology revealed that UCB-derived MSCs induced regeneration of rotator cuff tendon tear and that the regenerated tissue was predominantly composed of type I collagens. In this study, ultrasound-guided injection of human UCB-derived MSCs contributed to regeneration of the full-thickness rotator cuff tendon tear without surgical repair. The results demonstrate the effectiveness of local injection of MSCs into the rotator cuff tendon.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Significance<\/jats:title>\n                  <jats:p>The results of this study suggest that ultrasound-guided umbilical cord blood-derived mesenchymal stem cell injection may be a useful conservative treatment for full-thickness rotator cuff tendon tear repair.<\/jats:p>\n               <\/jats:sec>","DOI":"10.5966\/sctm.2015-0040","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T02:09:55Z","timestamp":1442282995000},"page":"1344-1351","source":"Crossref","is-referenced-by-count":56,"title":["Regeneration of Full-Thickness Rotator Cuff Tendon Tear After Ultrasound-Guided Injection With Umbilical Cord Blood-Derived Mesenchymal Stem Cells in a Rabbit Model"],"prefix":"10.1093","volume":"4","author":[{"given":"Gi-Young","family":"Park","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Rak","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Chul","family":"Lee","sequence":"additional","affiliation":[{"name":"Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,9,14]]},"reference":[{"key":"2021122704421703600_R1","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1164\/rccm.200902-0242OC","article-title":"Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease","volume":"180","author":"Aslam","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"2021122704421703600_R2","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00296-008-0733-2","article-title":"The efficacy of conservative treatment in patients with full-thickness rotator cuff tears","volume":"29","author":"Baydar","year":"2009","journal-title":"Rheumatol Int"},{"key":"2021122704421703600_R3","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1080\/14653240600941549","article-title":"Differentiation of umbilical cord blood-derived multilineage progenitor cells into respiratory epithelial cells","volume":"8","author":"Berger","year":"2006","journal-title":"Cytotherapy"},{"key":"2021122704421703600_R4","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nrm1744","article-title":"Regulatory networks in embryo-derived pluripotent stem cells","volume":"6","author":"Boiani","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2021122704421703600_R5","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1177\/0363546510390780","article-title":"Platelet-rich plasma augmentation for arthroscopic rotator cuff repair: a randomized controlled trial","volume":"39","author":"Castricini","year":"2011","journal-title":"Am J Sports Med"},{"key":"2021122704421703600_R6","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.3727\/096368911X565038a","article-title":"Intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells dose-dependently attenuates hyperoxia-induced lung injury in neonatal rats","volume":"20","author":"Chang","year":"2011","journal-title":"Cell Transplant"},{"key":"2021122704421703600_R7","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3727\/096368909X471189","article-title":"Human umbilical cord blood-derived mesenchymal stem cells attenuate hyperoxia-induced lung injury in neonatal rats","volume":"18","author":"Chang","year":"2009","journal-title":"Cell Transplant"},{"key":"2021122704421703600_R8","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1007\/s11999-010-1323-7","article-title":"Strategies in biologic augmentation of rotator cuff repair: A review","volume":"468","author":"Cheung","year":"2010","journal-title":"Clin Orthop Relat Res"},{"key":"2021122704421703600_R9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2106\/00004623-200101000-00010","article-title":"Surgical repair of chronic rotator cuff tears. 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