{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:52:06Z","timestamp":1792273926434,"version":"4.4.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T00:00:00Z","timestamp":1457395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title\/>\n                  <jats:p>Human placental mesenchymal stromal cells (pMSCs) have never been investigated in intrauterine growth restriction (IUGR). We characterized cells isolated from placental membranes and the basal disc of six IUGR and five physiological placentas. Cell viability and proliferation were assessed every 7 days during a 6-week culture. Expression of hematopoietic, stem, endothelial, and mesenchymal markers was evaluated by flow cytometry. We characterized the multipotency of pMSCs and the expression of genes involved in mitochondrial content and function. Cell viability was high in all samples, and proliferation rate was lower in IUGR compared with control cells. All samples presented a starting heterogeneous population, shifting during culture toward homogeneity for mesenchymal markers and occurring earlier in IUGR than in controls. In vitro multipotency of IUGR-derived pMSCs was restricted because their capacity for adipocyte differentiation was increased, whereas their ability to differentiate toward endothelial cell lineage was decreased. Mitochondrial content and function were higher in IUGR pMSCs than controls, possibly indicating a shift from anaerobic to aerobic metabolism, with the loss of the metabolic characteristics that are typical of undifferentiated multipotent cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Significance<\/jats:title>\n                  <jats:p>This study demonstrates that the loss of endothelial differentiation potential and the increase of adipogenic ability are likely to play a significant role in the vicious cycle of abnormal placental development in intrauterine growth restriction (IUGR). This is the first observation of a potential role for placental mesenchymal stromal cells in intrauterine growth restriction, thus leading to new perspectives for the treatment of IUGR.<\/jats:p>\n               <\/jats:sec>","DOI":"10.5966\/sctm.2015-0155","type":"journal-article","created":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T03:24:37Z","timestamp":1457493877000},"page":"451-463","source":"Crossref","is-referenced-by-count":24,"title":["Impaired Angiogenic Potential of Human Placental Mesenchymal Stromal Cells in Intrauterine Growth Restriction"],"prefix":"10.1093","volume":"5","author":[{"given":"Chiara","family":"Mand\u00f2","sequence":"first","affiliation":[{"name":"\u201cL. Sacco\u201d Department of Biomedical and Clinical Sciences, Center for Fetal Research Giorgio Pardi, Universit\u00e1 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Razini","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory, Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari, Universit\u00e1 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Novielli","sequence":"additional","affiliation":[{"name":"\u201cL. Sacco\u201d Department of Biomedical and Clinical Sciences, Center for Fetal Research Giorgio Pardi, Universit\u00e1 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia Maria","family":"Anelli","sequence":"additional","affiliation":[{"name":"\u201cL. Sacco\u201d Department of Biomedical and Clinical Sciences, Center for Fetal Research Giorgio Pardi, Universit\u00e1 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Belicchi","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory, Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari, Universit\u00e1 degli Studi di Milano, Milan, Italy"},{"name":"Ystem S.R.L., Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Erratico","sequence":"additional","affiliation":[{"name":"Ystem S.R.L., Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Banfi","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory, Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari, Universit\u00e1 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella","family":"Meregalli","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory, Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari, Universit\u00e1 degli Studi di Milano, Milan, Italy"},{"name":"Ystem S.R.L., Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Tavelli","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory, Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari, Universit\u00e1 degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Baccarin","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Genetics, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Rolfo","sequence":"additional","affiliation":[{"name":"Department of Surgical Science, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Motta","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Genetics, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvan","family":"Torrente","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory, Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari, Universit\u00e1 degli Studi di Milano, Milan, Italy"},{"name":"Ystem S.R.L., Milan, Italy"},{"name":"UNISTEM Interdepartmental Centre for Stem Cell Research, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Cetin","sequence":"additional","affiliation":[{"name":"\u201cL. Sacco\u201d Department of Biomedical and Clinical Sciences, Center for Fetal Research Giorgio Pardi, Universit\u00e1 degli Studi di Milano, Milan, Italy"},{"name":"Department of Mother and Child, Luigi Sacco Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,3,8]]},"reference":[{"key":"2021122705023486800_R1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.placenta.2014.04.001","article-title":"JunB\/cyclin-D1 imbalance in placental mesenchymal stromal cells derived from preeclamptic pregnancies with fetal-placental compromise","volume":"35","author":"Nuzzo","year":"2014","journal-title":"Placenta"},{"key":"2021122705023486800_R2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. 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