{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:45:55Z","timestamp":1784630755090,"version":"3.55.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":1913,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Krabbe disease, or globoid cell leukodystrophy, is a rare disorder caused by deficient galactosylceramidase activity and loss of myelin-forming oligodendrocytes, resulting in progressive demyelination and severely impaired motor function. Disease symptoms in humans appear within 3\u20136 months of age (early infantile) and manifest as marked irritability, spasticity, and seizures. The disease is often fatal by the second year of life, with few effective treatment options. Herein we evaluated the therapeutic potential of mesenchymal stem cells (MSCs) administered intracranially to a 1-month-old rhesus macaque diagnosed with severe early-onset Krabbe disease that displayed neurologic and behavioral symptoms similar to those of human patients. The infant was subjected to physical and neurological behavior examinations and nerve conduction velocity tests to assess efficacy, and outcomes were compared with age-matched normal infants and Krabbe-affected rhesus monkeys with late-onset disease. Changes in major blood lymphocyte populations were also monitored to assess host immune cell responses. MSC administration resulted in transient improvements in coordination, ambulation, cognition, and large motor skills, which correlated with increased peripheral nerve conduction velocities and decreased latencies. Improvements also corresponded to transient increases in peripheral blood lymphocyte counts, but secondary challenge failed to elicit allo-antibody production. Nevertheless, white cell and neutrophil counts showed dramatic increases, and CD20+ B cell counts underwent a precipitous decline at late stages of disease progression. Correlative data linking MSC administration to transient improvements in motor function suggest that MSCs should be evaluated further as an experimental therapy for rare neurodegenerative diseases.<\/jats:p>","DOI":"10.5966\/sctm.2015-0317","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T02:49:13Z","timestamp":1472093353000},"page":"99-109","source":"Crossref","is-referenced-by-count":10,"title":["Mesenchymal Stem Cells Yield Transient Improvements in Motor Function in an Infant Rhesus Macaque with Severe Early-Onset Krabbe Disease"],"prefix":"10.1093","volume":"6","author":[{"given":"Irina A.","family":"Isakova","sequence":"first","affiliation":[{"name":"a Donahue's Consulting Inc., New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate C.","family":"Baker","sequence":"additional","affiliation":[{"name":"b Department of Veterinary Medicine, Tulane National Primate Research Center, Covington, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Dufour","sequence":"additional","affiliation":[{"name":"b Department of Veterinary Medicine, Tulane National Primate Research Center, Covington, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald G.","family":"Phinney","sequence":"additional","affiliation":[{"name":"c Department of Molecular Therapeutics, The Scripps Research Institute\u2013Scripps Florida, Jupiter, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,8,24]]},"reference":[{"key":"2022022809214134800_R1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/978-1-4614-0653-2_13","article-title":"Leukodystrophies","volume":"724","author":"Perlman","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"2022022809214134800_R2","volume-title":"Krabbe disease","author":"Wenger","year":"1993"},{"issue":"suppl 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