{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:30:58Z","timestamp":1768321858229,"version":"3.49.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":1888,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cardiac tissue engineering, which combines cells and biomaterials, is promising for limiting the sequelae of myocardial infarction (MI). We assessed myocardial function and scar evolution after implanting an engineered bioactive impedance graft (EBIG) in a swine MI model. The EBIG comprises a scaffold of decellularized human pericardium, green fluorescent protein-labeled porcine adipose tissue-derived progenitor cells (pATPCs), and a customized-design electrical impedance spectroscopy (EIS) monitoring system. Cardiac function was evaluated noninvasively by using magnetic resonance imaging (MRI). Scar healing was evaluated by using the EIS system within the implanted graft. Additionally, infarct size, fibrosis, and inflammation were explored by histopathology. Upon sacrifice 1 month after the intervention, MRI detected a significant improvement in left ventricular ejection fraction (7.5% \u00b1 4.9% vs. 1.4% \u00b1 3.7%; p = .038) and stroke volume (11.5 \u00b1 5.9 ml vs. 3 \u00b1 4.5 ml; p = .019) in EBIG-treated animals. Noninvasive EIS data analysis showed differences in both impedance magnitude ratio (\u22120.02 \u00b1 0.04 per day vs. \u22120.48 \u00b1 0.07 per day; p = .002) and phase angle slope (\u22120.18\u00b0 \u00b1 0.24\u00b0 per day vs. \u22123.52\u00b0 \u00b1 0.84\u00b0 per day; p = .004) in EBIG compared with control animals. Moreover, in EBIG-treated animals, the infarct size was 48% smaller (3.4% \u00b1 0.6% vs. 6.5% \u00b1 1%; p = .015), less inflammation was found by means of CD25+ lymphocytes (0.65 \u00b1 0.12 vs. 1.26 \u00b1 0.2; p = .006), and a lower collagen I\/III ratio was detected (0.49 \u00b1 0.06 vs. 1.66 \u00b1 0.5; p = .019). An EBIG composed of acellular pericardium refilled with pATPCs significantly reduced infarct size and improved cardiac function in a preclinical model of MI. Noninvasive EIS monitoring was useful for tracking differential scar healing in EBIG-treated animals, which was confirmed by less inflammation and altered collagen deposit.<\/jats:p>","DOI":"10.5966\/sctm.2016-0063","type":"journal-article","created":{"date-parts":[[2016,9,3]],"date-time":"2016-09-03T02:58:39Z","timestamp":1472871519000},"page":"647-655","source":"Crossref","is-referenced-by-count":28,"title":["Noninvasive Assessment of an Engineered Bioactive Graft in Myocardial Infarction: Impact on Cardiac Function and Scar Healing"],"prefix":"10.1093","volume":"6","author":[{"given":"Carolina","family":"G\u00e1lvez-Mont\u00f3n","sequence":"first","affiliation":[{"name":"a ICREC (Heart Failure and Cardiac Regeneration) Research Programme, Fundaci\u00f3 Institut d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon","family":"Brag\u00f3s","sequence":"additional","affiliation":[{"name":"b Electronic and Biomedical Instrumentation Group, Electronic Engineering Department, Universitat Polit\u00e8cnica de Catalunya, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Soler-Botija","sequence":"additional","affiliation":[{"name":"a ICREC (Heart Failure and Cardiac Regeneration) Research Programme, Fundaci\u00f3 Institut d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idoia","family":"D\u00edaz-G\u00fcemes","sequence":"additional","affiliation":[{"name":"c Jes\u00fas Us\u00f3n Minimally Invasive Surgery Centre, C\u00e1ceres, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Prat-Vidal","sequence":"additional","affiliation":[{"name":"a ICREC (Heart Failure and Cardiac Regeneration) Research Programme, Fundaci\u00f3 Institut d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Cris\u00f3stomo","sequence":"additional","affiliation":[{"name":"c Jes\u00fas Us\u00f3n Minimally Invasive Surgery Centre, C\u00e1ceres, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco M.","family":"S\u00e1nchez-Margallo","sequence":"additional","affiliation":[{"name":"c Jes\u00fas Us\u00f3n Minimally Invasive Surgery Centre, C\u00e1ceres, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Lluci\u00e0-Valldeperas","sequence":"additional","affiliation":[{"name":"a ICREC (Heart Failure and Cardiac Regeneration) Research Programme, Fundaci\u00f3 Institut d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paco","family":"Bog\u00f3nez-Franco","sequence":"additional","affiliation":[{"name":"b Electronic and Biomedical Instrumentation Group, Electronic Engineering Department, Universitat Polit\u00e8cnica de Catalunya, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Perea-Gil","sequence":"additional","affiliation":[{"name":"a ICREC (Heart Failure and Cardiac Regeneration) Research Programme, Fundaci\u00f3 Institut d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Roura","sequence":"additional","affiliation":[{"name":"a ICREC (Heart Failure and Cardiac Regeneration) Research 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