{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:19:24Z","timestamp":1791389964331,"version":"4.3.3"},"reference-count":0,"publisher":"IMR Press","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HSF"],"abstract":"<jats:p>Objectives: For a long time, the association of the false lumen status and the outcomes of patients suffering from aortic dissection has been unclear, so this review article aims to study whether the unobstructed of the false lumen is related to the outcome of patients suffering from aortic dissection. Methods: We performed this systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta Analyzes Protocols (PRISMA) statement 2009 and registered with PROSPERO (CRD42022381869). We searched PubMed, the Cochrane library, Web of Science and Embase to collect potential studies. The Newcastle-Ottawa Scale was used to assess the quality of the included studies. The main outcome is long-term survival. Data included in the study were summarized using the risk ratio or mean difference and 95% confidence interval. Results: There were 16 trials, 2829 patients in total, with a mean age of 62.1 years. Compared with completely thrombosed false lumen, patent group has better long-term survival (risk ratio (RR), 0.88\u037e 95% CI, 0.79 to 0.97\u037e p = 0.01\u037e I2 = 58%) and smaller yearly aortic growth rate (mean difference (MD), 1.03\u037e 95% CI, 0.23 to 1.82\u037e p = 0.01\u037e I2 = 98%). In addition, patients with a patent false lumen had a lower risk of aortic event (RR, 0.81\u037e 95% CI, 0.68 to 0.97\u037e p = 0.02\u037e I2 = 37%), but higher risk of aortic rupture (RR, 7.02\u037e 95% CI, 2.55 to 19.3\u037e p = 0.0002\u037e I2 = 0) and hospital death (RR, 2.72\u037e 95% CI, 1.45 to 5.08\u037e p = 0.002\u037e I2 = 0). Conclusion: Completely thrombosed of the false lumen is more beneficial to the long-term survival of patients with aortic dissection. And the risk of aortic rupture and hospital death in patients with patent false lumen is 7 times and 3 times that of patients with complete thrombosed false lumen. It is expected to provide individualized medical care for different types of patients according to different false lumen status to minimize death and related complications.<\/jats:p>","DOI":"10.59958\/hsf.5739","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:42:49Z","timestamp":1698799369000},"page":"E628-E638","source":"Crossref","is-referenced-by-count":11,"title":["Does False Lumen Thrombosis Lead to Better Outcomes in Patients with Aortic Dissection: A Meta-Analysis and Systematic Review"],"prefix":"10.31083","volume":"26","author":[{"given":"Shiming","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shidong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruisheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","published-online":{"date-parts":[[2023,10,30]]},"container-title":["The Heart Surgery Forum"],"original-title":[],"link":[{"URL":"https:\/\/journal.hsforum.com\/index.php\/HSF\/article\/download\/5739\/8515","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journal.hsforum.com\/index.php\/HSF\/article\/download\/5739\/8515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T08:40:59Z","timestamp":1760690459000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/HSF\/26\/5\/10.59958\/hsf.5739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,30]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,9,6]]}},"URL":"https:\/\/doi.org\/10.59958\/hsf.5739","relation":{},"ISSN":["1522-6662","1098-3511"],"issn-type":[{"value":"1522-6662","type":"electronic"},{"value":"1098-3511","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10,30]]}}}