{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T23:02:37Z","timestamp":1754262157243},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":2180,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"tdm","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["www.e-aps.org"],"crossmark-restriction":true},"short-container-title":["Arch Plast Surg"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>\n          Background  Median cleft lip is a rare anomaly consisting of a midline vertical cleft through the upper lip. It can also involve the premaxillary bone, the nasal septum, and the central nervous system. In our current report, we present the clinical features of 6 patients with a median cleft lip and their surgical management according to the accompanying anomalies.<\/jats:p><jats:p>\n          Methods  From December 2010 to January 2014, 6 patients with a median cleft lip were reviewed. Five of these cases underwent surgical correction; alveolar bone grafting was performed in a patient with a median alveolar cleft. The surgical technique included inverted-U excision of the upper lip and repair of the orbicularis oris muscle. The mean follow-up period was 20.4 months (range, 7.4\u201344.0 months).<\/jats:p><jats:p>\n          Results  The study patients presented various anomalous features. Five patients received surgical correction, 4 with repair of the median cleft lip, and one with iliac bone grafting for median alveolar cleft. A patient with basal sphenoethmoidal meningocele was managed with transoral endoscopic surgery for repair of the meningocele. Successful surgical repair was achieved in all cases with no postoperative complications.<\/jats:p><jats:p>\n          Conclusions  Relatively mild forms of median cleft lip can be corrected with inverted-U excision with good aesthetic outcomes. In addition, there is a broad spectrum of clinical features and various anomalies, such as nasal deformity, alveolar cleft, and short upper frenulum, which require close evaluation. The timing of the operation should be decided considering the presence of other anomalies that can threaten patient survival.<\/jats:p>","DOI":"10.5999\/aps.2016.43.3.242","type":"journal-article","created":{"date-parts":[[2016,5,20]],"date-time":"2016-05-20T15:31:40Z","timestamp":1463758300000},"page":"242-247","update-policy":"http:\/\/dx.doi.org\/10.5999\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical Features and Management of a Median Cleft Lip"],"prefix":"10.1055","volume":"43","author":[{"given":"Kyung S.","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Suk","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1097\/00001665-200309000-00028","article-title":"Median clefts of the upper lip: a review and surgical management of a minor manifestation","volume":"14","author":"MM Urata","year":"2003","journal-title":"J Craniofac Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1212\/WNL.17.10.961","article-title":"The median cleft face syndrome: differential diagnosis of cranium bifidum occultum, hypertelorism, and median cleft nose, lip, and palate","volume":"17","author":"W DeMyer","year":"1967","journal-title":"Neurology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1597\/1545-1569_1993_030_0094_mcotli_2.3.co_2","article-title":"Median cleft of the lip: its significance and surgical repair","volume":"30","author":"J Apesos","year":"1993","journal-title":"Cleft Palate Craniofac J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1097\/SCS.0b013e3181ae42bf","article-title":"Consideration of median cleft lip with frenulum labii superior","volume":"20","author":"M Ichida","year":"2009","journal-title":"J Craniofac Surg"},{"key":"ref5","first-page":"573","article-title":"Congenital malformations in the frontonasal area: their pathogenesis and classification","volume":"3","author":"RF Mazzola","year":"1976","journal-title":"Clin Plast Surg"},{"key":"ref6","first-page":"727","volume-title":"Median cleft lip with hypertelorism","author":"DR Millard","year":"1977"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1597\/09-065","article-title":"Median cleft of the upper lip: a rare case","volume":"47","author":"NP Patel","year":"2010","journal-title":"Cleft Palate Craniofac J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.jcms.2014.01.003","article-title":"Median cleft of the upper lip associated with a mass: a rare case","volume":"42","author":"XC Jian","year":"2014","journal-title":"J Craniomaxillofac Surg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.ijom.2008.07.010","article-title":"Alveolar bone grafting in the treatment of midline alveolar cleft and diastema in incomplete median cleft lip","volume":"37","author":"HT Liao","year":"2008","journal-title":"Int J Oral Maxillofac Surg"}],"container-title":["Archives of Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.e-aps.org\/upload\/pdf\/aps-43-242.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.e-aps.org\/journal\/view.php?doi=10.5999\/aps.2016.43.3.242","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.5999\/aps.2016.43.3.242.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T23:43:50Z","timestamp":1650498230000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.5999\/aps.2016.43.3.242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":9,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2022,4,20]]},"published-print":{"date-parts":[[2016,5]]}},"URL":"https:\/\/doi.org\/10.5999\/aps.2016.43.3.242","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2234-6163","2234-6171"],"issn-type":[{"value":"2234-6163","type":"print"},{"value":"2234-6171","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"2016-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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