{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T03:01:39Z","timestamp":1782702099055,"version":"3.54.5"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":1996,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T00:00:00Z","timestamp":1479427200000},"content-version":"tdm","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["www.e-aps.org"],"crossmark-restriction":true},"short-container-title":["Arch Plast Surg"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>\n          Background  Hypertrophic scarring is a pathological condition that occurs after trauma or surgery. Angiogenesis occurs more often with hypertrophic scarring than with normotrophic scarring. The regulation of angiogenesis is one of the key factors in hypertrophic scar management. Vascular endothelial growth factor (VEGF) is an essential factor in the angiogenetic response. This study investigated whether decreasing the level of VEGF is effective for treating hypertrophic scarring.<\/jats:p><jats:p>\n          Methods  Ten 8-week-old female New Zealand white rabbits were included. Four defects were created on each ear by using a 6-mm punch. Bevacizumab (Avastin, Roche Pharma, Basel, Switzerland) was administered in one ear and normal saline was administered in the other ear. Treatment was administered starting on day 2, every 2 days, until day 14. The levels of VEGF were measured using enzyme-linked immunosorbent assay on day 10 and histologic results were analyzed on day 40.<\/jats:p><jats:p>\n          Results  Bevacizumab induced-defects showed less hypertrophic scarring when compared with the control group as measured by the scar elevation index (SEI) and loose collagen arrangement. The SEI in the experimental group was 1.89\u00b10.13, compared to 1.99\u00b10.13 in the control group (n=30, P=0.005). Additionally, the VEGF level was lower (38.72\u00b111.03 pg vs. 82.50\u00b121.64 pg, n=10, P=0.001) and fewer vessels existed (8.58\u00b10.76 vs. 7.2\u00b11.20, n=10, P=0.007).<\/jats:p><jats:p>\n          Conclusions  Preventing excessive angiogenesis is effective for preventing scar formation, especially with hypertrophic scarring. Although it is not an approach that is sufficient alone for the management of scarring, it may be one of several important strategies for scar treatment.<\/jats:p>","DOI":"10.5999\/aps.2016.43.6.491","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T02:47:12Z","timestamp":1479869232000},"page":"491-497","update-policy":"https:\/\/doi.org\/10.5999\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Anti-Vascular Endothelial Growth Factor (Bevacizumab) Therapy Reduces Hypertrophic Scar Formation in a Rabbit Ear Wounding Model"],"prefix":"10.1055","volume":"43","author":[{"given":"Do Hoon","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Hui","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Seob","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Koo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/PRS.0b013e3181c82dd5","article-title":"The most current algorithms for the treatment and prevention of hypertrophic scars and keloids","volume":"125","author":"R Ogawa","year":"2010","journal-title":"Plast Reconstr Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1097\/BOR.0b013e32835b13b6","article-title":"Angiogenesis and scar formation in healing wounds","volume":"25","author":"LA DiPietro","year":"2013","journal-title":"Curr Opin Rheumatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1524-475X.2011.00692.x","article-title":"Time course of the angiogenic response during normotrophic and hypertrophic scar formation in humans","volume":"19","author":"WM van der Veer","year":"2011","journal-title":"Wound 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(Avastin) in rabbits","volume":"51","author":"C Sinapis","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1089\/jir.2007.0104","article-title":"Improved scar in postburn patients following interferon-alpha2b treatment is associated with decreased angiogenesis mediated by vascular endothelial cell growth factor","volume":"28","author":"J Wang","year":"2008","journal-title":"J Interferon Cytokine Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/labinvest.2008.36","article-title":"Regulation of scar formation by vascular endothelial growth factor","volume":"88","author":"TA Wilgus","year":"2008","journal-title":"Lab Invest"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/00006534-199709000-00021","article-title":"Acute and chronic animal models for excessive dermal scarring: quantitative studies","volume":"100","author":"DE 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