{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:24:01Z","timestamp":1789683841479,"version":"4.0.1"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":1996,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T00:00:00Z","timestamp":1479427200000},"content-version":"tdm","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["www.e-aps.org"],"crossmark-restriction":true},"short-container-title":["Arch Plast Surg"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>\n          Background  Cutaneous squamous cell carcinoma (SCC), which occurs in keratinocytes of the epidermis and is the second most common skin cancer, has a more invasive growth pattern and higher potential to metastasize than basal cell carcinoma. Total excision of the primary tumor is the treatment of choice. For clear excision of the tumor, invasion depth is one of the most important factors. This study was conducted to clarify the relationship between the size and the invasion depth of cutaneous SCC.<\/jats:p><jats:p>\n          Methods  Twenty-six cases were collected for this prospective study. Frozen biopsies were examined after complete resection of the tumor, followed by histological confirmation by pathological examination. The major and minor axis lengths of the tumor, the invasion depth, and the level of invasion were measured. Recurrence or metastasis was recorded through regular follow-up.<\/jats:p><jats:p>\n          Results  The Pearson correlation coefficient was used for statistical analysis. Significant results were observed for the relationship between the major and minor axis lengths and the invasion depth of the tumor (0.747, 0.773). No cases of recurrence or metastasis were observed.<\/jats:p><jats:p>\n          Conclusions  In head and neck cutaneous SCC, the invasion depth of the tumor is closely related to the major and minor axis lengths of the tumor. Therefore, the invasion depth of the tumor can be estimated by measuring the size of the tumor, and a standard vertical safety margin for head and neck cutaneous SCC can be established, which could be helpful in the development of a preoperative reconstruction plan.<\/jats:p>","DOI":"10.5999\/aps.2016.43.6.538","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T02:48:43Z","timestamp":1479869323000},"page":"538-543","update-policy":"https:\/\/doi.org\/10.5999\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Relationship between the Size and the Invasion Depth of Tumors in Head and Neck Cutaneous Squamous Cell Carcinoma"],"prefix":"10.1055","volume":"43","author":[{"given":"Sam Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Chonnam National University Medical School, Gwangju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Joo","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Chonnam National University Medical School, Gwangju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Pil","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Chonnam National University Medical School, Gwangju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Chonnam National University Medical School, Gwangju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Ha","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Chonnam National University Medical School, Gwangju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Seog","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Chonnam National University Medical School, Gwangju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0190-9622(92)70074-P","article-title":"Squamous cell carcinoma of the skin (excluding lip and oral mucosa)","volume":"26","author":"TM Johnson","year":"1992","journal-title":"J Am Acad Dermatol"},{"key":"ref2","first-page":"1413","article-title":"Clinical observation of cutaneous malignant tumors and premalignant lesions over 15 years (1982-1996)","volume":"37","author":"HG Chung","year":"1999","journal-title":"Korean J Dermatol"},{"key":"ref3","author":"Statistics 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the patient with primary cutaneous squamous cell carcinoma","volume":"146","author":"R Motley","year":"2002","journal-title":"Br J Dermatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/1097-0142(196404)17:4<535::AID-CNCR2820170415>3.0.CO;2-P","article-title":"The treatment of skin cancer: a statistical study of 1,341 skin tumors comparing results obtained with irradiation, surgery, and curettage followed by electrodesiccation","volume":"17","author":"RG Freeman","year":"1964","journal-title":"Cancer"},{"key":"ref9","volume-title":"Available from:","author":"CK Bichakjian","year":"2015"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0190-9622(92)70001-V","article-title":"Biology of cutaneous squamous cell carcinoma","volume":"26","author":"RE Kwa","year":"1992","journal-title":"J Am Acad 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Implications for treatment modality selection","volume":"26","author":"DE Rowe","year":"1992","journal-title":"J Am Acad Dermatol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000246783","article-title":"Metastases from squamous cell carcinoma of the skin in southern Australia","volume":"189","author":"D Czarnecki","year":"1994","journal-title":"Dermatology"},{"key":"ref14","first-page":"97","article-title":"Prevention, early detection and team management of skin cancer in primary care: contribution to The health of the nation objectives","volume":"45","author":"A Jackson","year":"1995","journal-title":"Br J Gen Pract"},{"key":"ref15","first-page":"268","article-title":"Prognostic factors for metastasis in squamous cell carcinoma of the skin","volume":"28","author":"BS Cherpelis","year":"2002","journal-title":"Dermatol Surg"}],"container-title":["Archives of Plastic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.e-aps.org\/upload\/pdf\/aps-43-538.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.e-aps.org\/journal\/view.php?doi=10.5999\/aps.2016.43.6.538","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.5999\/aps.2016.43.6.538.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T22:52:17Z","timestamp":1650495137000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.5999\/aps.2016.43.6.538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":15,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2022,4,20]]},"published-print":{"date-parts":[[2016,11]]}},"URL":"https:\/\/doi.org\/10.5999\/aps.2016.43.6.538","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2234-6163","2234-6171"],"issn-type":[{"value":"2234-6163","type":"print"},{"value":"2234-6171","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"2016-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-18","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-15","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}