{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:45:28Z","timestamp":1761896728952,"version":"3.37.3"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T00:00:00Z","timestamp":1653177600000},"content-version":"vor","delay-in-days":1543,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T00:00:00Z","timestamp":1521072000000},"content-version":"tdm","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["www.e-aps.org"],"crossmark-restriction":true},"short-container-title":["Arch Plast Surg"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>\nBackground  Non-syndromic craniosynostosis causes craniofacial asymmetry and may persist after cranioplasty. These postoperative asymmetries are primarily depressions. In some cases, patients may be subjected to pranks and harassment by their peers, affecting their psychosocial development. We propose lipoinjection enriched with adipose stem cells (ASCs) to treat the sequelae of craniosynostosis in the fronto-orbital and temporal complex in cranioplasty patients, with the goal of improving the appearance of the upper third of the face.<\/jats:p><jats:p>\nMethods  Twelve children (four boys and eight girls) between 4 and 8 years of age (mean age, 6 years) in the postoperative period after treatment for plagiocephaly, brachycephaly, and trigonocephaly were included, with a follow-up period of 1 to 18 months. Fat tissue was obtained from the lower abdomen, and ASCs were isolated using the Yoshimura technique. Lipoinjection was performed using several mini-approaches to ensure adequate distribution.<\/jats:p><jats:p>\nResults  Two different scales were used to evaluate the aesthetic outcomes. At 6 months, three plastic surgeons independent of the study classified the results using a Likert scale. The patients\u2019 parents categorized the results using a visual analog scale at 6, 9, and 18 months. R esults were favorable on both scales, as the patients\u2019 facial appearance improved and they reported increased happiness and self-esteem due to their remodeled facial appearance.<\/jats:p><jats:p>\nConclusions  We suggest that lipoinjection enriched with ASCs is a good alternative for correcting asymmetry of the fronto-orbital and temporal contour in patients with sequelae of craniosynostosis. This treatment will help boost patients\u2019 self-esteem starting at an early age.<\/jats:p>","DOI":"10.5999\/aps.2017.00997","type":"journal-article","created":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T09:07:12Z","timestamp":1521450432000},"page":"128-134","update-policy":"https:\/\/doi.org\/10.5999\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Volumetric lipoinjection of the fronto-orbital and temporal complex with adipose stem cells for the aesthetic restoration of sequelae of craniosynostosis"],"prefix":"10.1055","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1121-4333","authenticated-orcid":false,"given":"Yanko","family":"Castro-Govea","sequence":"additional","affiliation":[{"name":"Plastic Surgery Service, Hospital Universitario \u201cDr. Jose E. Gonzalez\u201d, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"Vela-Martinez","sequence":"additional","affiliation":[{"name":"Plastic Surgery Service, Hospital Universitario \u201cDr. Jose E. Gonzalez\u201d, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Alberto","family":"Trevi\u00f1o-Garcia","sequence":"additional","affiliation":[{"name":"Plastic Surgery Service, Hospital Universitario \u201cDr. Jose E. Gonzalez\u201d, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00001665-200501000-00009","article-title":"Late results after unicoronal craniosynostosis correction","volume":"16","author":"PJ Anderson","year":"2005","journal-title":"J Craniofac Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/00001665-199607000-00007","article-title":"Surgery for unilateral coronal synostosis (plagiocephaly): unilateral or bilateral correction?","volume":"7","author":"S Sgouros","year":"1996","journal-title":"J Craniofac Surg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/SCS.0000000000002585","article-title":"Long-term assessment of suturectomy in trigonocephaly and anterior plagiocephaly","volume":"27","author":"A 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supportive use of human adipose-derived cells for soft tissue augmentation with lipoinjection","volume":"12","author":"D Matsumoto","year":"2006","journal-title":"Tissue Eng"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00266-009-9339-7","article-title":"Adipose-derived mesenchymal stem cells: past, present, and future","volume":"33","author":"G Rigotti","year":"2009","journal-title":"Aesthetic Plast Surg"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1097\/PRS.0b013e3181b5a3f1","article-title":"Characterization of structure and cellular components of aspirated and excised adipose tissue","volume":"124","author":"H Eto","year":"2009","journal-title":"Plast Reconstr Surg"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"659","DOI":"10.5999\/aps.2012.39.6.659","article-title":"Cell-assisted lipotransfer for the treatment of parry-romberg syndrome","volume":"39","author":"Y 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