{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:45:10Z","timestamp":1778319910221,"version":"3.51.4"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T00:00:00Z","timestamp":1648944000000},"content-version":"vor","delay-in-days":1249,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"tdm","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-aps.org"],"crossmark-restriction":true},"short-container-title":["Arch Plast Surg"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>Kaposiform hemangioendothelioma (KHE) is a very rare, locally aggressive vascular neoplasm. It occurs mostly in children and is rarely observed in adults. It typically originates on the skin, later affecting the deep soft tissue of the extremities, head or neck, and retroperitoneum by infiltrative growth. It is locally aggressive, does not regress spontaneously, and tends to metastasize locally as well as to the regional lymph nodes. In this article, we report a case of adult-onset KHE with neurofibromatosis type 1. The patient presented to our department with a 2-month history of a painful ulceration in her left popliteal area. Since KHE had not previously been reported in patients with neurofibromatosis, the diagnosis was difficult due to the similarity of the skin manifestation to neurofibromatosis-associated lesions. We share our experience of diagnosing and treating this rare case of adult-onset KHE.<\/jats:p>","DOI":"10.5999\/aps.2017.01032","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T01:31:07Z","timestamp":1542591067000},"page":"583-587","update-policy":"https:\/\/doi.org\/10.5999\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Adult-onset kaposiform hemangioendothelioma with neurofibromatosis type 1: A case report and literature review"],"prefix":"10.1055","volume":"45","author":[{"given":"Dong Hwi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Bucheon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Sung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Bucheon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Weon","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Uijeongbu St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean A","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Bucheon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Joon","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Bucheon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,4,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejim.2008.06.008","article-title":"Kaposiform hemangioendothelioma","volume":"20","author":"Y Fernandez","year":"2009","journal-title":"Eur J Intern Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1053\/j.semdp.2012.01.003","article-title":"Hemangioendothelioma","volume":"30","author":"L Requena","year":"2013","journal-title":"Semin Diagn Pathol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00000478-200405000-00001","article-title":"Kaposiform hemangioendothelioma: a study of 33 cases emphasizing its pathologic, immunophenotypic, and biologic uniqueness from juvenile hemangioma","volume":"28","author":"LL Lyons","year":"2004","journal-title":"Am J Surg 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