{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:34:13Z","timestamp":1758893653039},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":1692,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T00:00:00Z","timestamp":1505433600000},"content-version":"tdm","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["www.e-aps.org"],"crossmark-restriction":true},"short-container-title":["Arch Plast Surg"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>\nBackground  This study aimed to assess the effects of the topical application of tamoxifen on wound healing of burned skin in Wistar rats by evaluating 3 healing characteristics: fibrotic tissue thickness (FTT), scar surface area (SSA), and angiogenesis in the healed scar tissue.<\/jats:p><jats:p>\nMethods  Eighteen male Wistar rats were used in this study. A third-degree burn wound was made on the shaved animals\u2019 back, measuring 2\u00d72\u00d72 cm. In the first group, a 2% tamoxifen ointment was applied to the wound twice daily for 8 weeks. The second group received a placebo ointment during the same period. The third group did not receive any treatment and served as the control group.<\/jats:p><jats:p>\nResults  The median (interquartile range=[Q1, Q3]) FTT was 1.35 (1.15, 1.62) mm, 1.00 (0.95, 1.02) mm, and 1.25 (0.8, 1.5) mm in the control, tamoxifen, and placebo groups, respectively (P=0.069). However, the FTT in the tamoxifen group was less than in the placebo and control groups. The median angiogenesis was 3.5 (3.00, 6.25), 8.00 (6.75, 9.25), and 7.00 (5.50, 8.25) vessels per high-power field for the control, tamoxifen, and placebo groups, respectively (P=0.067). However, the median angiogenesis was higher in the tamoxifen group than in the control group. No significant difference was observed in the mean SSA between the tamoxifen group and the control group (P=0.990).<\/jats:p><jats:p>\nConclusions  Local application of tamoxifen increased angiogenesis and decreased the FTT, with no change in the SSA in burned skin areas. These effects are expected to expedite the wound healing process, reducing contracture and preventing hypertrophic scar and keloid formation.<\/jats:p>","DOI":"10.5999\/aps.2017.44.5.378","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T05:00:33Z","timestamp":1505970033000},"page":"378-383","update-policy":"http:\/\/dx.doi.org\/10.5999\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of Topical Tamoxifen on Wound Healing of Burned Skin in Rats"],"prefix":"10.1055","volume":"44","author":[{"given":"Shaban","family":"Mehrvarz","sequence":"additional","affiliation":[{"name":"Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hedayat","family":"Sahraei","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, and Behavioral Sciences Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Hasan","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sima","family":"Fazili","sequence":"additional","affiliation":[{"name":"Department of Pathology, Baqiyatallah University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahram","family":"Manoochehry","sequence":"additional","affiliation":[{"name":"Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamid Reza","family":"Rasouli","sequence":"additional","affiliation":[{"name":"Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/00006534-200208000-00031","article-title":"International clinical recommendations on scar management","volume":"110","author":"TA Mustoe","year":"2002","journal-title":"Plast Reconstr Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1006\/jsre.2001.6350","article-title":"Tamoxifen decreases fibroblast function and downregulates TGF (beta2) in dupuytren\u2019s affected palmar fascia","volume":"103","author":"MA Kuhn","year":"2002","journal-title":"J Surg Res"},{"key":"ref3","first-page":"213","article-title":"Effect of 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