{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:25:47Z","timestamp":1780518347916,"version":"3.54.1"},"reference-count":0,"publisher":"Vilnius University Press","issue":"1","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AML"],"abstract":"<jats:p>Introduction. Testicular cancer and a\u00a0multiple birth are both rare events, and the\u00a0risk of testicular cancer is increased in twins. In Lithuania, only five quadruplets have been recorded since the\u00a0middle of the\u00a020th century. In this report, we present two rare events in one family: testicular cancer in two brothers of a\u00a0quadruplet (three brothers and a\u00a0sister).\n Case description. Both patients were diagnosed at 21 years of age and died within two years from the\u00a0 diagnosis despite treatment. The\u00a0 third symptomless brother did not have testicular pathology. We also review the\u00a0 risk factors associated with testicular cancer, and the\u00a0 proposed hypotheses how a\u00a0multiple birth results in an increased risk. The\u00a0most consistent risk factors for testicular cancer are cryptorchidism, prior history of testicular cancer, and a\u00a0positive familial history. According to different studies, the\u00a0risk of testicular cancer in twins is higher from 22% to 30%, compared to the\u00a0general population.\n Conclusions. To our knowledge, we have presented the\u00a0first case of testicular teratoblastoma in brothers of a\u00a0quadruplet.<\/jats:p>","DOI":"10.6001\/actamedica.v24i1.3458","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T14:14:26Z","timestamp":1493129666000},"page":"12-17","source":"Crossref","is-referenced-by-count":1,"title":["Testicular cancer in two brothers of a\u00a0quadruplet: a\u00a0case report and a\u00a0review of literature"],"prefix":"10.15388","volume":"24","author":[{"given":"Agn\u0117","family":"Ulyt\u0117","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albertas","family":"Ulys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u0119stutis","family":"Su\u017eied\u0117lis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Au\u0161vydas","family":"Pata\u0161ius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giedr\u0117","family":"Smailyt\u0117","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6097","published-online":{"date-parts":[[2017,4,25]]},"container-title":["Acta medica Lituanica"],"original-title":[],"link":[{"URL":"https:\/\/www.journals.vu.lt\/AML\/article\/download\/21337\/20449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.journals.vu.lt\/AML\/article\/download\/21337\/20449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T06:16:35Z","timestamp":1610000195000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.journals.vu.lt\/AML\/article\/view\/21337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,25]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,4,25]]}},"URL":"https:\/\/doi.org\/10.6001\/actamedica.v24i1.3458","relation":{},"ISSN":["2029-4174","1392-0138"],"issn-type":[{"value":"2029-4174","type":"electronic"},{"value":"1392-0138","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4,25]]}}}