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ERA-EDTA Council; ERACODA Working Group. Chronic kidney disease is a key risk factor for severe COVID-19: a call to action by the ERA-EDTA. Nephrol Dial Transplant. 2021;36(1):87-94. doi:10.1093\/ndt\/gfaa314","DOI":"10.1093\/ndt\/gfaa314"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2. Zhang C, Shi L, Wang FS. Liver injury in COVID-19: management and challenges. Lancet Gastroenterol Hepatol. 2020;5(5):428-430. doi:10.1016\/S2468-1253(20)30057-1","DOI":"10.1016\/S2468-1253(20)30057-1"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Jin X, Lian JS, Hu JH, et al. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut. 2020;69(6):1002-1009. doi:10.1136\/gutjnl-2020-320926","DOI":"10.1136\/gutjnl-2020-320926"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. Tian Y, Rong L, Nian W, He Y. 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