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Ely EW, Gautam S, Margolin R, et al. The impact of delirium in the intensive care unit on hospital length of stay. Intensive Care Med. 2001;27(12):1892-1900. doi:10.1007\/s00134-001-1132-2","DOI":"10.1007\/s00134-001-1132-2"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"2. Ely EW, Shintani A, Truman B, et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA. 2004;291(14):1753-1762. doi:10.1001\/jama.291.14.1753","DOI":"10.1001\/jama.291.14.1753"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"3. Girard TD, Jackson JC, Pandharipande PP, et al. Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med. 2010;38(7):1513-1520. doi:10.1097\/CCM.0b013e3181e47be1","DOI":"10.1097\/CCM.0b013e3181e47be1"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"4. Milbrandt EB, Deppen S, Harrison PL, et al. Costs associated with delirium in mechanically ventilated patients. Crit Care Med. 2004;32(4):955-962. doi:10.1097\/01.ccm.0000119429.16055.92","DOI":"10.1097\/01.CCM.0000119429.16055.92"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"5. Beckmann S, Schubert M, Burkhalter H, Dutkowski P, De Geest S. Postoperative delirium after liver transplantation is associated with increased length of stay and lower survival in a prospective cohort. Prog Transplant. 2017;27(1):23-30. doi:10.1177\/1526924816679838","DOI":"10.1177\/1526924816679838"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"6. Bhattacharya B, Maung A, Barre K, et al. Postoperative delirium is associated with increased intensive care unit and hospital length of stays after liver transplantation. J Surg Res. 2017;207:223-228. doi:10.1016\/j.jss.2016.08.084","DOI":"10.1016\/j.jss.2016.08.084"},{"key":"ref7","unstructured":"7. Oliver N, Bohorquez H, Anders S, et al. Post-liver transplant delirium increases mortality and length of stay. Ochsner J. 2017;17(1):25-30."},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"8. Wu SY, Chen TW, Feng AC, Fan HL, Hsieh CB, Chung KP. Comprehensive risk assessment for early neurologic complications after liver transplantation. World J Gastroenterol. 2016;22(24):5548-5557. doi:10.3748\/wjg.v22.i24.5548","DOI":"10.3748\/wjg.v22.i24.5548"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"9. Wang SH, Wang JY, Lin PY, et al. Predisposing risk factors for delirium in living donor liver transplantation patients in intensive care units. PLoS One. 2014;9(5):e96676. doi:10.1371\/journal.pone.0096676","DOI":"10.1371\/journal.pone.0096676"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"10. Pinero F, Mendizabal M, Quiros R, et al. Neurological events after liver transplantation: a single-center experience. Transpl Int. 2014;27(12):1244-1252. doi:10.1111\/tri.12404","DOI":"10.1111\/tri.12404"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"11. Lescot T, Karvellas CJ, Chaudhury P, et al. Postoperative delirium in the intensive care unit predicts worse outcomes in liver transplant recipients. Can J Gastroenterol. 2013;27(4):207-212. doi:10.1155\/2013\/289185","DOI":"10.1155\/2013\/289185"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"12. Lee H, Oh SY, Yu JH, Kim J, Yoon S, Ryu HG. Risk factors of postoperative delirium in the intensive care unit after liver transplantation. World J Surg. 2018;42(9):2992-2999. doi:10.1007\/s00268-018-4563-4","DOI":"10.1007\/s00268-018-4563-4"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"13. Lee H, Ju JW, Oh SY, Kim J, Jung CW, Ryu HG. Impact of timing and duration of postoperative delirium: a retrospective observational study. Surgery. 2018;S0039-6060(18)30035-7. doi:10.1016\/j.surg.2018.02.001","DOI":"10.1016\/j.surg.2018.02.001"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"14. Balderramo D, Prieto J, Cardenas A, Navasa M. Hepatic encephalopathy and post-transplant hyponatremia predict early calcineurin inhibitor-induced neurotoxicity after liver transplantation. Transpl Int. 2011;24(8):812-819. doi:10.1111\/j.1432-2277.2011.01280.x","DOI":"10.1111\/j.1432-2277.2011.01280.x"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"15. DiMartini A, Fontes P, Dew MA, Lotrich FE, de Vera M. Age, model for end-stage liver disease score, and organ functioning predict posttransplant tacrolimus neurotoxicity. Liver Transpl. 2008;14(6):815-822. doi:10.1002\/lt.21427","DOI":"10.1002\/lt.21427"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"16. Garcia-Martinez R, Rovira A, Alonso J, et al. 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Consensus conference: Indications for Liver Transplantation, January 19 and 20, 2005, Lyon-Palais Des Congres: text of recommendations (long version). Liver Transpl. 2006;12(6):998-1011. doi:10.1002\/lt.20765","DOI":"10.1002\/lt.20765"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"37. Testino G, Burra P, Bonino F, et al. Acute alcoholic hepatitis, end stage alcoholic liver disease and liver transplantation: an Italian position statement. World J Gastroenterol. 2014;20(40):14642-14651. doi:10.3748\/wjg.v20.i40.14642","DOI":"10.3748\/wjg.v20.i40.14642"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"38. Antonini TM, Guillaud O, Dumortier J, et al. Impact of a first study of early transplantation in acute alcoholic hepatitis: results of a nationwide survey in french liver transplantation programs. Liver Transpl. 2018;24(6):841-844. doi:10.1002\/lt.25039","DOI":"10.1002\/lt.25039"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"39. Zhu J, Chen PY, Frankel M, Selby RR, Fong TL. Contemporary policies regarding alcohol and marijuana use among liver transplant programs in the United States. Transplantation. 2018;102(3):433-439. doi:10.1097\/TP.0000000000001969","DOI":"10.1097\/TP.0000000000001969"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"40. Kodali S, Kaif M, Tariq R, Singal AK. Alcohol relapse after liver transplantation for alcoholic cirrhosis-impact on liver graft and patient survival: a meta-analysis. Alcohol Alcohol. 2018;53(2):166-172. doi:10.1093\/alcalc\/agx098","DOI":"10.1093\/alcalc\/agx098"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"41. Braun HJ, Ascher NL. Living donor liver transplantation for alcoholic liver disease. Alcohol Alcohol. 2018;53(2):178-183. doi:10.1093\/alcalc\/agx099","DOI":"10.1093\/alcalc\/agx099"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"42. Chung HG, Sinn DH, Kang W, Choi GS, Kim JM, Joh JW. 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