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CMAJ. 2019 Sep 9;191(36):E989-E1004. doi: 10.1503\/cmaj.181504.","DOI":"10.1503\/cmaj.181504"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"[5] L\u00f6scher W, Klein P. New approaches for developing multi-targeted drug combinations for disease modification of complex brain disorders. Does epilepsy prevention become a realistic goal? Pharmacol Ther. 2022 Jan;229:107934. doi: 10.1016\/j.pharmthera.2021.107934. Epub 2021 Jun 30.","DOI":"10.1016\/j.pharmthera.2021.107934"},{"key":"ref5","unstructured":"[6] Wu Chaoyin. The study of compatibility of \"Chan\" disease based on data mining of ancient and modern literature. Guangzhou University of Chinese Medicine, 2020. doi:10.27044\/d.cnki.ggzzu.2020.000037."},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"[7] Michel HE, Tadros MG, Esmat A, Khalifa AE, Abdel-Tawab AM. Tetramethylpyrazine Ameliorates Rotenone-Induced Parkinson's Disease in Rats: Involvement of Its Anti-Inflammatory and Anti-Apoptotic Actions. Mol Neurobiol. 2017 Sep;54(7):4866-4878. doi: 10.1007\/s12035-016-0028-7. Epub 2016 Aug 11.","DOI":"10.1007\/s12035-016-0028-7"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"[8] Lu C, Zhang J, Shi X, et al. Neuroprotective effects of tetramethylpyrazine against dopaminergic neuron injury in a rat model of Parkinson's disease induced by MPTP. Int J Biol Sci. 2014 Mar 13;10(4):350-7. doi: 10.7150\/ijbs.8366.","DOI":"10.7150\/ijbs.8366"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"[9] Miao WG, Nguyen T, Iqbal J, et al. Meeting the Challenge 2: Identification of Potential Chemical Probes for Parkinson's Disease from Ligusticum chuanxiong Hort Using Cytological Profiling. ACS Chem Neurosci. 2022 Aug 26. doi: 10.1021\/acschemneuro.1c00820. Epub ahead of print.","DOI":"10.1021\/acschemneuro.1c00820"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"[10] Yang M, Wang CC, Wang WL, et al. Saposhnikovia divaricata-An Ethnopharmacological, Phytochemical and Pharmacological Review. Chin J Integr Med. 2020 Nov;26(11):873-880. doi: 10.1007\/s11655-020-3091-x. Epub 2020 Apr 21.","DOI":"10.1007\/s11655-020-3091-x"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"[11] Muhammad J, Khan A, Ali A, et al. Network Pharmacology: Exploring the Resources and Methodologies. Curr Top Med Chem. 2018;18(12):949-964. doi: 10.2174\/ 1568026618666180330141351.","DOI":"10.2174\/1568026618666180330141351"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"[12] Nogales C, Mamdouh ZM, List M, Kiel C, Casas AI, Schmidt HHHW. Network pharmacology: curing causal mechanisms instead of treating symptoms. Trends Pharmacol Sci. 2022 Feb;43(2):136-150. doi: 10.1016\/j.tips.2021.11.004. Epub 2021 Dec 9.","DOI":"10.1016\/j.tips.2021.11.004"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"[13] Zhou M. Network Pharmacology Approach to Investigate the Mechanism of Modified Liu Jun Zi Decoction in the Treatment of Chronic Atrophic Gastritis. Evid Based Complement Alternat Med. 2022 Jun 17;2022:7536042. doi: 10.1155\/2022\/7536042.","DOI":"10.1155\/2022\/7536042"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"[14] Wang Y, Li X, Dou P, Qiao T, Chang Y. Antiepileptic Therapy of Abrus cantoniensis: Evidence from Network Pharmacology. Evid Based Complement Alternat Med. 2022 Jun 6;2022:7748787. doi: 10.1155\/2022\/7748787.","DOI":"10.1155\/2022\/7748787"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"[15] Pahal S, Gupta A, Choudhary P, Chaudhary A, Singh S. Network pharmacological evaluation of Withania somnifera bioactive phytochemicals for identifying novel potential inhibitors against neurodegenerative disorder. J Biomol Struct Dyn. 2021 Jul 19:1-12. doi: 10.1080\/07391102.2021.1951355. Epub ahead of print.","DOI":"10.1080\/07391102.2021.1951355"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"[16] Luo K, Huang W, Qiao L, et al. Dendrocalamus latiflorus and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production via AKT activation. Acta Pharm Sin B. 2022 May;12(5):2239-2251. doi: 10.1016\/j.apsb.2021.11.017. Epub 2021 Nov 18.","DOI":"10.1016\/j.apsb.2021.11.017"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"[17] Ru J, Li P, Wang J, et al. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminform. 2014 Apr 16;6:13. doi: 10.1186\/1758-2946-6-13.","DOI":"10.1186\/1758-2946-6-13"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"[18] Ye XW, Wang HL, Cheng SQ, Xia LJ, Xu XF, Li XR. Network Pharmacology-Based Strategy to Investigate the Pharmacologic Mechanisms of Coptidis Rhizoma for the Treatment of Alzheimer's Disease. 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Nucleic Acids Res. 2021 Jan 8;49(D1):D605-D612. doi: 10.1093\/nar\/gkaa1074.","DOI":"10.1093\/nar\/gkaa1074"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"[22] Tiwari R, Mahasenan K, Pavlovicz R, Li C, Tjarks W. Carborane clusters in computational drug design: a comparative docking evaluation using AutoDock, FlexX, Glide, and Surflex. J Chem Inf Model. 2009 Jun;49(6):1581-9. doi: 10.1021\/ci900031y.","DOI":"10.1021\/ci900031y"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"[23] Yu Q, Wang F, Hu X, et al. Comparison of two docking methods for peptide-protein interactions. J Sci Food Agric. 2018 Aug;98(10):3722-3727. doi: 10.1002\/jsfa.8880. Epub 2018 Feb 26.","DOI":"10.1002\/jsfa.8880"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"[24] Dion\u00edsio PA, Amaral JD, Rodrigues CMP. Oxidative stress and regulated cell death in Parkinson's disease. Ageing Res Rev. 2021 May;67:101263. doi: 10.1016\/j.arr.2021.101263. Epub 2021 Feb 1.","DOI":"10.1016\/j.arr.2021.101263"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"[25] Musgrove RE, Helwig M, Bae EJ, et al. Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular \u03b1-synuclein transfer. J Clin Invest. 2019;129(9):3738-3753. Published 2019 Jun 13. doi:10.1172\/JCI127330.","DOI":"10.1172\/JCI127330"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"[26] Goedert M, Jakes R, Spillantini MG. The Synucleinopathies: Twenty Years On. J Parkinsons Dis. 2017;7(s1):S51-S69. doi: 10.3233\/JPD-179005. PMID: 28282814; PMCID: PMC5345650.","DOI":"10.3233\/JPD-179005"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"[27] Leandrou E, Emmanouilidou E, Vekrellis K. Voltage-Gated Calcium Channels and \u03b1-Synuclein: Implications in Parkinson's Disease. Front Mol Neurosci. 2019 Oct 9;12:237. doi: 10.3389\/fnmol.2019.00237.","DOI":"10.3389\/fnmol.2019.00237"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"[28] Benkert J, Hess S, Roy S, et al. Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson's disease. Nat Commun. 2019 Nov 8;10(1):5094. doi: 10.1038\/s41467-019-12834-x.","DOI":"10.1038\/s41467-019-12834-x"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"[29] Bloem BR, Okun MS, Klein C. Parkinson's disease. Lancet. 2021 Jun 12;397(10291):2284-2303. doi: 10.1016\/S0140-6736(21)00218-X. Epub 2021 Apr 10. PMID: 33848468.","DOI":"10.1016\/S0140-6736(21)00218-X"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"[30] Jiang YH , Li X , Niu W , Wang D , Wu B , Yang CH . \u03b2-Sitosterol regulated microRNAs in endothelial cells against an oxidized low-density lipoprotein. Food Funct. 2020 Feb 26;11(2):1881-1890. doi: 10.1039\/c9fo01976f.","DOI":"10.1039\/C9FO01976F"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"[31] Liu WL, Wu BF, Shang JH, Zhao YL, Huang AX. Moringa oleifera Lam Seed Oil Augments Pentobarbital-Induced Sleeping Behaviors in Mice via GABAergic Systems. J Agric Food Chem. 2020 Mar 11;68(10):3149-3162. doi: 10.1021\/acs.jafc.0c00037. Epub 2020 Feb 28.","DOI":"10.1021\/acs.jafc.0c00037"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"[32] Zhang Y, Liang J, Jiang H, Qian M, Zhao W, Bai W. Protective effect of sterols extracted from Lotus plumule on ethanol-induced injury in GES-1 cells in vitro. Food Funct. 2021 Dec 13;12(24):12659-12670. doi: 10.1039\/d1fo02684d.","DOI":"10.1039\/D1FO02684D"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"[33] Mahmoudi R, Ghareghani M, Zibara K, et al. Alyssum homolocarpum seed oil (AHSO), containing natural alpha linolenic acid, stearic acid, myristic acid and \u03b2-sitosterol, increases proliferation and differentiation of neural stem cells in vitro. BMC Complement Altern Med. 2019 Jun 3;19(1):113. doi: 10.1186\/s12906-019-2518-4.","DOI":"10.1186\/s12906-019-2518-4"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"[34] Qi G, Mi Y, Fan R, Li R, Liu Z, Liu X. Nobiletin Protects against Systemic Inflammation-Stimulated Memory Impairment via MAPK and NF-\u03baB Signaling Pathways. J Agric Food Chem. 2019 May 8;67(18):5122-5134. doi: 10.1021\/acs.jafc.9b00133. Epub 2019 Apr 24.","DOI":"10.1021\/acs.jafc.9b00133"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"[35] Pochard C, Leclair-Visonneau L, Coron E, Neunlist M, Rolli-Derkinderen M, Derkinderen P. Cyclooxygenase 2 is upregulated in the gastrointestinal tract in Parkinson's disease. Mov Disord. 2018 Mar;33(3):493-494. doi: 10.1002\/mds.27237. Epub 2017 Nov 18.","DOI":"10.1002\/mds.27237"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"[36] Tatton WG, Chalmers-Redman R, Brown D, Tatton N. Apoptosis in Parkinson's disease: signals for neuronal degradation. Ann Neurol. 2003;53 Suppl 3:S61-70; discussion S70-2. doi: 10.1002\/ana.10489.","DOI":"10.1002\/ana.10489"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"[37] Ran C, Westerlund M, Anvret A, et al. Genetic studies of the protein kinase AKT1 in Parkinson's disease. Neurosci Lett. 2011 Aug 21;501(1):41-4. doi: 10.1016\/j.neulet.2011.06.038. Epub 2011 Jun 29.","DOI":"10.1016\/j.neulet.2011.06.038"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"[38] Maiese K, Chong ZZ, Shang YC, Wang S. Targeting disease through novel pathways of apoptosis and autophagy. Expert Opin Ther Targets. 2012 Dec;16(12):1203-14. doi: 10.1517\/14728222.2012.719499. Epub 2012 Aug 27. 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