{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T09:51:17Z","timestamp":1782899477829,"version":"3.54.5"},"reference-count":30,"publisher":"Baskent University","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Transplant"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.6002\/ect.2026.0024","type":"journal-issue","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T09:21:59Z","timestamp":1782897719000},"source":"Crossref","is-referenced-by-count":0,"title":[],"prefix":"10.6002","volume":"24","member":"4021","reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Quattrin T, Mastrandrea LD, Walker LSK. Type 1 diabetes. Lancet. 2023;401(10394):2149-2162. doi:10.1016\/S0140-6736(23)00223-4","DOI":"10.1016\/S0140-6736(23)00223-4"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2. Addison P, Fatakhova K, Rodriguez Rilo HL. Considerations for an alternative site of islet cell transplantation. J Diabetes Sci Technol. 2020;14(2):338-344. doi:10.1177\/1932296819868495","DOI":"10.1177\/1932296819868495"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Pellegrini S. Chapter 65: Alternative transplantation sites for islet transplantation. In: Orlando G, Piemonti L, Ricordi C, Stratta RJ, Gruessner RW, eds. Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas. Academic Press; 2019:833-847. doi:10.1016\/B978-0-12-814833-4.00065-4","DOI":"10.1016\/B978-0-12-814833-4.00065-4"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. Cayabyab F, Nih LR, Yoshihara E. Advances in pancreatic islet transplantation sites for the treatment of diabetes. Front Endocrinol (Lausanne). 2021;12:732431. doi:10.3389\/fendo.2021.732431","DOI":"10.3389\/fendo.2021.732431"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5. Pepper AR, Gala-Lopez B, Pawlick R, Merani S, Kin T, Shapiro AMJ. A prevascularized subcutaneous device-less site for islet and cellular transplantation. Nature Biotechnol. 2015;33(5):518-523. doi:10.1038\/nbt.3211","DOI":"10.1038\/nbt.3211"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. Dubiel EA, Jonathan, Lamb MW, Vermette P. Culturing free-floating and fibrin-embedded islets with endothelial cells: effects on insulin secretion and apoptosis. Cell Mol Bioeng. 2014;7(2):243-253. doi:10.1007\/s12195-014-0332-0","DOI":"10.1007\/s12195-014-0332-0"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. Bowers DT, Song W, Wang LH, Ma M. Engineering the vasculature for islet transplantation. Acta Biomater. 2019;95:131-151. doi:10.1016\/j.actbio.2019.05.051","DOI":"10.1016\/j.actbio.2019.05.051"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Luciana Mateus Gon\u00e7alves, Alma\u00e7a J. Functional characterization of the human islet microvasculature using living pancreas slices. Front Endocrinol (Lausanne). 2021;11:602519. doi:10.3389\/fendo.2020.602519","DOI":"10.3389\/fendo.2020.602519"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9. Luan NM, Iwata H. Long-term allogeneic islet graft survival in prevascularized subcutaneous sites without immunosuppressive treatment. Am J Transplant. 2014;14(7):1533-1542. doi:10.1111\/ajt.12739","DOI":"10.1111\/ajt.12739"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10. Sp\u00e4ter T, Frueh FS, Nickels RM, Menger MD, Laschke MW. Prevascularization of collagen-glycosaminoglycan scaffolds: stromal vascular fraction versus adipose tissue-derived microvascular fragments. J Biol Eng. 2018;12(1):24. doi:10.1186\/s13036-018-0118-3","DOI":"10.1186\/s13036-018-0118-3"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11. Vlahos AE, Talior-Volodarsky I, Kinney SM, Sefton MV. A scalable device-less biomaterial approach for subcutaneous islet transplantation. Biomaterials. 2021;269:120499. doi:10.1016\/j.biomaterials.2020.120499","DOI":"10.1016\/j.biomaterials.2020.120499"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12. Zhou X, Xu Z, You Y, et al. Subcutaneous device-free islet transplantation. Front Immunol. 2023;14:1287182. doi:10.3389\/fimmu.2023.1287182","DOI":"10.3389\/fimmu.2023.1287182"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"13. Frueh FS, Sp\u00e4ter T, Scheuer C, Menger MD, Laschke MW. Isolation of murine adipose tissue-derived microvascular fragments as vascularization units for tissue engineering. J Vis Exp. 2017;(122):55721. doi:10.3791\/55721","DOI":"10.3791\/55721"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14. Laschke MW, Menger MD. Adipose tissue-derived microvascular fragments: natural vascularization units for regenerative medicine. Trends Biotechnol. 2015;33(8):442-448. doi:10.1016\/j.tibtech.2015.06.001","DOI":"10.1016\/j.tibtech.2015.06.001"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15. Nalbach L, M\u00fcller D, Wrublewsky S, et al. Microvascular fragment spheroids: three-dimensional vascularization units for tissue engineering and regeneration. J Tissue Eng. 2021;12:20417314211035593. doi:10.1177\/20417314211035593","DOI":"10.1177\/20417314211035593"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16. Sp\u00e4ter T, Marschall JE, Br\u00fccker LK, et al. Vascularization of microvascular fragment isolates from visceral and subcutaneous adipose tissue of mice. Tissue Eng Regen Med. 2022;19(1):161-175. doi:10.1007\/s13770-021-00391-8","DOI":"10.1007\/s13770-021-00391-8"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17. Ahmed TAE, Dare EV, Hincke M. Fibrin: A versatile scaffold for tissue engineering applications. Tissue Eng Part B Rev. 2008;14(2):199-215. doi:10.1089\/ten.teb.2007.0435","DOI":"10.1089\/ten.teb.2007.0435"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"18. Riopel M, Stuart W, Wang R. Fibrin improves beta (INS-1) cell function, proliferation and survival through integrin \u03b1v\u03b23. Acta Biomater. 2013;9(9):8140-8148. doi:10.1016\/j.actbio.2013.05.035","DOI":"10.1016\/j.actbio.2013.05.035"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"19. Najjar M, Manzoli V, Abreu M, et al. Fibrin gels engineered with pro-angiogenic growth factors promote engraftment of pancreatic islets in extrahepatic sites in mice. Biotechnol Bioeng. 2015;112(9):1916-1926. doi:10.1002\/bit.25589","DOI":"10.1002\/bit.25589"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20. Kim JS, Lim JH, Nam HY, et al. In situ application of hydrogel-type fibrin-islet composite optimized for rapid glycemic control by subcutaneous xenogeneic porcine islet transplantation. J Control Release. 2012;162(2):382-390. doi:10.1016\/j.jconrel.2012.07.018","DOI":"10.1016\/j.jconrel.2012.07.018"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"21. Shepherd BR, Chen HYS, Smith CM, Gruionu G, Williams SK, Hoying JB. Rapid perfusion and network remodeling in a microvascular construct after implantation. Arterioscler Thromb Vasc Biol. 2004;24(5):898-904. doi:10.1161\/01.ATV.0000124103.86943.1e","DOI":"10.1161\/01.ATV.0000124103.86943.1e"},{"key":"ref21","unstructured":"22. Moazenchi M, Sadr Hashemi Nejad A, Izadi M, et al. Comparative study of the effects of confounding factors on improving rat pancreatic islet isolation yield and quality. Cell J. 2022;24(9):491-499. doi:10.22074\/cellj.2022.8123"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"23. Smink AM, Li S, Swart DH, et al. Stimulation of vascularization of a subcutaneous scaffold applicable for pancreatic islet\u2010transplantation enhances immediate post\u2010transplant islet graft function but not long\u2010term normoglycemia. J Biomed Mater Res A. 2017;105(9):2533-2542. doi:10.1002\/jbm.a.36101","DOI":"10.1002\/jbm.a.36101"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"24. Santini-Gonz\u00e1lez J, Simonovich JA, Castro-Guti\u00e9rrez R, et al. In vitro generation of peri-islet basement membrane-like structures. Biomaterials. 2021;273:120808. doi:10.1016\/j.biomaterials.2021.120808","DOI":"10.1016\/j.biomaterials.2021.120808"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25. Kuehn C, Lakey JR, Lamb MW, Vermette P. Young porcine endocrine pancreatic islets cultured in fibrin show improved resistance toward hydrogen peroxide. Islets. 2013;5(5):207-215. doi:10.4161\/isl.26989","DOI":"10.4161\/isl.26989"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"26. Salama BF, Seeberger KL, Korbutt GS. Fibrin supports subcutaneous neonatal porcine islet transplantation without the need for pre\u2010vascularization. Xenotransplantation. 2020;27(4):e12575. doi:10.1111\/xen.12575","DOI":"10.1111\/xen.12575"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"27. Nalbach L, Leticia Prates Roma, Schmitt BM, et al. Improvement of islet transplantation by the fusion of islet cells with functional blood vessels. EMBO Mol Med. 2021;13(1):e12616. doi:10.15252\/emmm.202012616","DOI":"10.15252\/emmm.202012616"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"28. Salamone M, Rigogliuso S, Nicosia A, Campora S, Bruno CM, Ghersi G. 3D collagen hydrogel promotes in vitro Langerhans islets vascularization through ad-MVFs angiogenic activity. Biomedicines. 2021;9(7):739. doi:10.3390\/biomedicines9070739","DOI":"10.3390\/biomedicines9070739"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"29. Aghazadeh Y, Poon F, Sarangi F, et al. Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models. Cell Stem Cell. 2021;28(11):1936-1949.e8. doi:10.1016\/j.stem.2021.08.001","DOI":"10.1016\/j.stem.2021.08.001"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"30. Wrublewsky S, Weinzierl A, Hornung I, et al. Co-transplantation of pancreatic islets and microvascular fragments effectively restores normoglycemia in diabetic mice. NPJ Regen Med. 2022;7(1):67. doi:10.1038\/s41536-022-00262-3","DOI":"10.1038\/s41536-022-00262-3"}],"container-title":["Experimental and Clinical Transplantation"],"original-title":[],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T09:36:29Z","timestamp":1782898589000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ectrx.org\/detail\/archive\/2026\/24\/5\/0\/419\/0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"URL":"https:\/\/doi.org\/10.6002\/ect.2026.0024","relation":{},"ISSN":["1304-0855","2146-8427"],"issn-type":[{"value":"1304-0855","type":"print"},{"value":"2146-8427","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}