{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T03:56:03Z","timestamp":1774497363464,"version":"3.50.1"},"reference-count":0,"publisher":"Harborside Press, LLC","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JADPRO"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:p>With the advent of high-throughput next-generation sequencing (NGS) and multigene panel testing, genetic testing and interpretations have become increasingly complex. Specifically, reports demonstrating \u201cvariant of uncertain significance\u201d (VUS) present interpretative challenges. Misinterpretation of a VUS may result in clinical harm, emotional distress for patients and family members, and potential health-care provider liability. The following article and deidentified case study illustrate how a lack of health-care provider and patient understanding of a germline VUS resulted in a negative patient outcome and unnecessary surgery.<\/jats:p>","DOI":"10.6004\/jadpro.2023.14.7.7","type":"journal-article","created":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T01:21:29Z","timestamp":1702171289000},"page":"631-638","source":"Crossref","is-referenced-by-count":4,"title":["When Germline Genetic Testing Results Are Unclear: Highlighting Variants of Uncertain Significance"],"prefix":"10.6004","volume":"14","author":[{"given":"Patricia","family":"Kelly, DNP, APRN, CNS, AGN-BC, AOCN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Mahon, DNS, RN, AOCN, AGN-BC, FAAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Friend, PhD, APRN-CNS, AOCNS, AGN-BC","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4047","published-online":{"date-parts":[[2023,11,1]]},"container-title":["Journal of the Advanced Practitioner in Oncology"],"original-title":[],"deposited":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T01:21:38Z","timestamp":1702171298000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.advancedpractitioner.com\/issues\/volume-14,-number-7-(novdec-2023)\/when-germline-genetic-testing-results-are-unclear-highlighting-variants-of-uncertain-significance.aspx"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":0,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,11,1]]},"published-print":{"date-parts":[[2023,11,1]]}},"URL":"https:\/\/doi.org\/10.6004\/jadpro.2023.14.7.7","relation":{},"ISSN":["2150-0878"],"issn-type":[{"value":"2150-0878","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11,1]]}}}