{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T07:11:20Z","timestamp":1722841880867},"reference-count":0,"publisher":"Harborside Press, LLC","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Atypical melanocytic tumors (AMTs) include a wide spectrum of melanocytic neoplasms that represent a challenge for clinicians due to the lack of a definitive diagnosis and the related uncertainty about their management. This study analyzed clinicopathologic features and sentinel node status as potential prognostic factors in patients with AMTs. <jats:bold>Patients and Methods:<\/jats:bold> Clinicopathologic and follow-up data of 238 children, adolescents, and adults with histologically proved AMTs consecutively treated at 12 European centers from 2000 through 2010 were retrieved from prospectively maintained databases. The binary association between all investigated covariates was studied by evaluating the Spearman correlation coefficients, and the association between progression-free survival and all investigated covariates was evaluated using univariable Cox models. The overall survival and progression-free survival curves were established using the Kaplan-Meier method. <jats:bold>Results:<\/jats:bold> Median follow-up was 126 months (interquartile range, 104\u2013157 months). All patients received an initial diagnostic biopsy followed by wide (1 cm) excision. Sentinel node biopsy was performed in 139 patients (58.4%), 37 (26.6%) of whom had sentinel node positivity. There were 4 local recurrences, 43 regional relapses, and 8 distant metastases as first events. Six patients (2.5%) died of disease progression. Five patients who were sentinel node\u2013negative and 3 patients who were sentinel node\u2013positive developed distant metastases. Ten-year overall and progression-free survival rates were 97% (95% CI, 94.9%\u201399.2%) and 82.2% (95% CI, 77.3%\u201387.3%), respectively. Age, mitotic rate\/mm<jats:sup>2<\/jats:sup>, mitoses at the base of the lesion, lymphovascular invasion, and 9p21 loss were factors affecting prognosis in the whole series and the sentinel node biopsy subgroup. <jats:bold>Conclusions:<\/jats:bold> Age &gt;20 years, mitotic rate &gt;4\/mm<jats:sup>2<\/jats:sup>, mitoses at the base of the lesion, lymphovascular invasion, and 9p21 loss proved to be worse prognostic factors in patients with ATMs. Sentinel node status was not a clear prognostic predictor.<\/jats:p>","DOI":"10.6004\/jnccn.2020.7582","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T19:19:31Z","timestamp":1602011971000},"page":"1327-1336","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of Sentinel Node Biopsy and Clinicopathologic Features as Prognostic Factors in Patients With Atypical Melanocytic Tumors"],"prefix":"10.6004","volume":"18","author":[{"given":"Andrea","family":"Maurichi","sequence":"first","affiliation":[{"name":"1Melanoma and Sarcoma Unit,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalba","family":"Miceli","sequence":"additional","affiliation":[{"name":"2Medical Statistics, Biometry and Bioinformatics Unit, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Patuzzo","sequence":"additional","affiliation":[{"name":"1Melanoma and Sarcoma Unit,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Barretta","sequence":"additional","affiliation":[{"name":"2Medical Statistics, Biometry and Bioinformatics Unit, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Gallino","sequence":"additional","affiliation":[{"name":"1Melanoma and Sarcoma Unit,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Mattavelli","sequence":"additional","affiliation":[{"name":"1Melanoma and Sarcoma Unit,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Consuelo","family":"Barbieri","sequence":"additional","affiliation":[{"name":"1Melanoma and Sarcoma Unit,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Leva","sequence":"additional","affiliation":[{"name":"1Melanoma and Sarcoma Unit,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Cortinovis","sequence":"additional","affiliation":[{"name":"1Melanoma and Sarcoma Unit,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Tolomio","sequence":"additional","affiliation":[{"name":"1Melanoma and Sarcoma Unit,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Sant","sequence":"additional","affiliation":[{"name":"3Analytical Epidemiology and Health Impact Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianpiero","family":"Castelli","sequence":"additional","affiliation":[{"name":"4Dermatology Unit, Ospedale Umberto I, Siracusa, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Zichichi","sequence":"additional","affiliation":[{"name":"5Dermatology Unit, Ospedale S.A. Abate, Trapani, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Pellacani","sequence":"additional","affiliation":[{"name":"6University Hospital of Modena, Modena, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignazio","family":"Stanganelli","sequence":"additional","affiliation":[{"name":"7University Hospital of Parma, Parma, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Simonacci","sequence":"additional","affiliation":[{"name":"8Dermatology Unit, Hospital of Macerata, Macerata, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ausilia","family":"Manganoni","sequence":"additional","affiliation":[{"name":"9University Hospital of Brescia, Brescia, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Del Forno","sequence":"additional","affiliation":[{"name":"10University Hospital of Pavia, Pavia, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gioachino","family":"Caresana","sequence":"additional","affiliation":[{"name":"11Dermatology Unit, Ospedale Maggiore, Cremona, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Harwood","sequence":"additional","affiliation":[{"name":"12Queen Mary University of London, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Bergamaschi","sequence":"additional","affiliation":[{"name":"12Queen Mary University of London, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Lasithiotakis","sequence":"additional","affiliation":[{"name":"13York Teaching Hospital NHS Foundation Trust, York, United Kingdom;"},{"name":"14University Hospital of Heraklion, Heraklion, Greece;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy","family":"Bennett","sequence":"additional","affiliation":[{"name":"15Molecular and Clinical Sciences Research Institute, St. George\u2019s, University of London, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittoria","family":"Espeli","sequence":"additional","affiliation":[{"name":"16Istituto Oncologico Svizzera Italiana, Ospedale Regionale Bellinzona e Valli, Bellinzona, Switzerland; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Mangas","sequence":"additional","affiliation":[{"name":"16Istituto Oncologico Svizzera Italiana, Ospedale Regionale Bellinzona e Valli, Bellinzona, Switzerland; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Leoni Parvex","sequence":"additional","affiliation":[{"name":"16Istituto Oncologico Svizzera Italiana, Ospedale Regionale Bellinzona e Valli, Bellinzona, Switzerland; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Valeri","sequence":"additional","affiliation":[{"name":"17Department of Pathology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara","family":"Cossa","sequence":"additional","affiliation":[{"name":"17Department of Pathology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Barisella","sequence":"additional","affiliation":[{"name":"17Department of Pathology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Pellegrinelli","sequence":"additional","affiliation":[{"name":"17Department of Pathology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Miranda","sequence":"additional","affiliation":[{"name":"18Scientific Directorate, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Anichini","sequence":"additional","affiliation":[{"name":"19Immunobiology of Human Tumors Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Mortarini","sequence":"additional","affiliation":[{"name":"19Immunobiology of Human Tumors Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odysseas","family":"Zoras","sequence":"additional","affiliation":[{"name":"14University Hospital of Heraklion, Heraklion, Greece;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Santinami","sequence":"additional","affiliation":[{"name":"1Melanoma and Sarcoma Unit,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4047","container-title":["Journal of the National Comprehensive Cancer Network"],"original-title":[],"link":[{"URL":"https:\/\/jnccn.org\/view\/journals\/jnccn\/18\/10\/article-p1327.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jnccn.org\/downloadpdf\/journals\/jnccn\/18\/10\/article-p1327.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T19:19:37Z","timestamp":1602011977000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnccn.org\/view\/journals\/jnccn\/18\/10\/article-p1327.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":0,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.6004\/jnccn.2020.7582","relation":{},"ISSN":["1540-1405","1540-1413"],"issn-type":[{"value":"1540-1405","type":"print"},{"value":"1540-1413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]}}}