{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:21:26Z","timestamp":1792754486267,"version":"4.5.0"},"reference-count":44,"publisher":"Harborside Press, LLC","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Available preliminary evidence is conflicting on whether exercise can positively influence antineoplastic treatment tolerance and in turn improve survival. <jats:bold>Patients and Methods:<\/jats:bold> This study compared chemotherapy treatment tolerance and survival among women receiving adjuvant chemotherapy for early-stage breast cancer who participated in a single-arm trial of supervised aerobic and resistance exercise programming versus a historical cohort that did not receive structured exercise programming. <jats:bold>Results:<\/jats:bold> The exercise group (EX; n=73) and control group (CTR; n=85) participants were matched on age and treatment and balanced on medical history, cancer diagnosis, and body mass index. Attendance in the EX group was 64%\u2009\u00b1\u200927% of 3 offered sessions per week. For all chemotherapy agents combined, the relative risk (RR) of a chemotherapy dose reduction (RR, 0.78; 95% CI, 0.54\u20131.11) or delay (RR, 1.05; 95% CI, 0.62\u20131.80) did not differ between groups. However, the EX group had reduced relative and absolute risks of a dose reduction in doxorubicin by 60% and 18%, respectively. For all agents combined, there were no differences between groups in risk of anemia, neutropenia, or weight gain. In the EX group, dose reductions due to neutropenia (<jats:italic>P<\/jats:italic>=.027), other infections (<jats:italic>P<\/jats:italic>=.049), and fatigue (<jats:italic>P<\/jats:italic>=.037) were less common, whereas mucositis was more common (<jats:italic>P<\/jats:italic>=.023), compared with the CTR group. The EX group had reduced relative and absolute risks of weight gain on the docetaxel + cyclophosphamide regimen by 38% and 30%, respectively. After a median follow-up of 70 months (range, 54\u201384 months), there was no difference between the EX and CTR groups in disease-free survival events (n=8 [11%] vs n=9 [11%], respectively; log-rank test, <jats:italic>P<\/jats:italic>=.78) or overall survival events (n=5 [7%] vs n=6 [7%], respectively; log-rank test, <jats:italic>P<\/jats:italic>=.974). <jats:bold>Conclusions:<\/jats:bold> Overall, exercise programming during adjuvant chemotherapy does not appear to impact treatment tolerance or survival in women receiving common modern regimens of adjuvant chemotherapy for early-stage breast cancer. However, exercise may provide selective benefits, depending on the treatment regimen received.<\/jats:p>","DOI":"10.6004\/jnccn.2020.7603","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T20:47:14Z","timestamp":1607374034000},"page":"1670-1677","source":"Crossref","is-referenced-by-count":20,"title":["Impact of Exercise on Chemotherapy Tolerance and Survival in Early-Stage Breast Cancer: A Nonrandomized Controlled Trial"],"prefix":"10.6004","volume":"18","author":[{"given":"Amy A.","family":"Kirkham","sequence":"first","affiliation":[{"name":"1University of Alberta, Edmonton, Alberta, Canada;"},{"name":"2Now: University of Toronto, Toronto, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A.","family":"Gelmon","sequence":"additional","affiliation":[{"name":"3British Columbia Cancer, Vancouver, British Columbia, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheri L.","family":"Van Patten","sequence":"additional","affiliation":[{"name":"3British Columbia Cancer, Vancouver, British Columbia, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelcey A.","family":"Bland","sequence":"additional","affiliation":[{"name":"4Australian Catholic University, Mary Mackillop Institute for Health Research, Melbourne, Victoria, Australia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Wollmann","sequence":"additional","affiliation":[{"name":"5University of British Columbia, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C.","family":"McKenzie","sequence":"additional","affiliation":[{"name":"5University of British Columbia, Vancouver, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taryne","family":"Landry","sequence":"additional","affiliation":[{"name":"5University of British Columbia, Vancouver, British Columbia, 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