{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:53:01Z","timestamp":1790319181296,"version":"4.1.0"},"reference-count":52,"publisher":"Harborside Press, LLC","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>Organ donors are systematically screened for infection, whereas screening for malignancy is less rigorous. The true incidence of donor-transmitted malignancies is unknown due to a lack of universal tumor testing in the posttransplant setting. Donor-transmitted malignancy may occur even when not suspected based on donor or recipient factors, including age and time to cancer diagnosis. We describe the detection of a gastrointestinal adenocarcinoma transmitted from a young donor to 4 transplant recipients. Multidimensional histopathologic and genomic profiling showed a<jats:italic>CDH1<\/jats:italic>mutation and<jats:italic>MET<\/jats:italic>amplification, consistent with gastric origin. At the time of writing, one patient in this series remains alive and without evidence of cancer after prompt organ explant after cancer was reported in other recipients. Because identification of a donor-derived malignancy changes management, our recommendation is to routinely perform short tandem repeat testing (or a comparable assay) immediately upon diagnosis of cancer in any organ transplant recipient. Routine testing for a donor-origin cancer and centralized reporting of outcomes are necessary to establish a robust evidence base for the future development of clinical practice guidelines.<\/jats:p>","DOI":"10.6004\/jnccn.2020.7622","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T20:24:08Z","timestamp":1604607848000},"page":"1446-1452","source":"Crossref","is-referenced-by-count":6,"title":["Molecular Insights in Transmission of Cancer From an Organ Donor to Four Transplant Recipients"],"prefix":"10.6004","volume":"18","author":[{"given":"Chloe E.","family":"Atreya","sequence":"first","affiliation":[{"name":"1Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco;"},{"name":"2UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Collisson","sequence":"additional","affiliation":[{"name":"1Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco;"},{"name":"2UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meyeon","family":"Park","sequence":"additional","affiliation":[{"name":"3Division of Nephrology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Grenert","sequence":"additional","affiliation":[{"name":"4Division of Surgical Pathology,"},{"name":"5Department of Pathology and Laboratory Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer C.","family":"Behr","sequence":"additional","affiliation":[{"name":"2UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco;"},{"name":"6Department of Radiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"7School of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Chou","sequence":"additional","affiliation":[{"name":"1Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco;"},{"name":"2UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Maisel","sequence":"additional","affiliation":[{"name":"1Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence W.","family":"Friedlander","sequence":"additional","affiliation":[{"name":"1Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco;"},{"name":"2UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris E.","family":"Freise","sequence":"additional","affiliation":[{"name":"8Division of Transplant Surgery, Department of Surgery, University of California, San Francisco, San Francisco, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shoji","sequence":"additional","affiliation":[{"name":"3Division of Nephrology, Department of Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Semrad","sequence":"additional","affiliation":[{"name":"9Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Van Ziffle","sequence":"additional","affiliation":[{"name":"5Department of Pathology and Laboratory Medicine,"},{"name":"10Clinical Cancer Genomics Laboratory, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Chin-Hong","sequence":"additional","affiliation":[{"name":"11Division of 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