{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:25:20Z","timestamp":1773872720131,"version":"3.50.1"},"reference-count":102,"publisher":"Harborside Press, LLC","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Individuals with a family history of pancreatic adenocarcinoma (PC) or with a germline mutation in a PC susceptibility gene are at increased risk of developing PC. These high-risk individuals (HRIs) may benefit from PC surveillance. <jats:bold>Methods:<\/jats:bold> A PC surveillance program was developed to evaluate the detection of premalignant lesions and early-stage PCs using biannual imaging and to determine whether locally advanced or metastatic PCs develop despite biannual surveillance. From January 2013 to April 2020, asymptomatic HRIs were enrolled and followed with alternating MRI and endoscopic ultrasound every 6 months. <jats:bold>Results:<\/jats:bold> Of 75 HRIs, 43 (57.3%) had a germline mutation in a PC susceptibility gene and 32 (42.7%) had a familial pancreatic cancer (FPC) pedigree. Branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) were identified in 26 individuals (34.7%), but only 2 developed progressive lesions. One patient with Peutz-Jeghers syndrome (PJS) developed locally advanced PC arising from a BD-IPMN. Whole-genome sequencing of this patient\u2019s PC and of a second patient with PJS-associated PC from the same kindred revealed biallelic inactivation of <jats:italic>STK11<\/jats:italic> in a <jats:italic>KRAS<\/jats:italic>-independent manner. A review of 3,853 patients from 2 PC registries identified an additional patient with PJS-associated PC. All 3 patients with PJS developed advanced PC consistent with the malignant transformation of an underlying BD-IPMN in &lt;6 months. The other surveillance patient with a progressive lesion had FPC and underwent resection of a mixed-type IPMN that harbored polyclonal <jats:italic>KRAS<\/jats:italic> mutations. <jats:bold>Conclusions:<\/jats:bold> PC surveillance identifies a high prevalence of BD-IPMNs in HRIs. Patients with PJS with BD-IPMNs may be at risk for accelerated malignant transformation.<\/jats:p>","DOI":"10.6004\/jnccn.2021.7107","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T18:17:27Z","timestamp":1655489847000},"page":"663-673.e12","source":"Crossref","is-referenced-by-count":7,"title":["Is Biannual Surveillance for Pancreatic Cancer Sufficient in Individuals With Genetic Syndromes or Familial Pancreatic Cancer?"],"prefix":"10.6004","volume":"20","author":[{"given":"Yifan","family":"Wang","sequence":"first","affiliation":[{"name":"1Department of Surgery, McGill University, Montreal, Quebec;"},{"name":"2Research Institute of the McGill University Health Centre, Montreal, Quebec;"},{"name":"3Rosalind and Morris Goodman Cancer Institute,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeline","family":"Cuggia","sequence":"additional","affiliation":[{"name":"2Research Institute of the McGill University Health Centre, Montreal, Quebec;"},{"name":"3Rosalind and Morris Goodman Cancer Institute,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-I","family":"Chen","sequence":"additional","affiliation":[{"name":"2Research Institute of the McGill University Health Centre, Montreal, Quebec;"},{"name":"4Division of Gastroenterology and Hepatology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9e","family":"Parent","sequence":"additional","affiliation":[{"name":"4Division of Gastroenterology and Hepatology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agatha","family":"Stanek","sequence":"additional","affiliation":[{"name":"2Research Institute of the McGill University Health Centre, Montreal, Quebec;"},{"name":"5Department of Diagnostic Radiology, McGill University, Montreal, Quebec;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Denroche","sequence":"additional","affiliation":[{"name":"6Ontario Institute for Cancer Research, Toronto, Ontario;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Zhang","sequence":"additional","affiliation":[{"name":"6Ontario Institute for Cancer Research, Toronto, Ontario;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Grant","sequence":"additional","affiliation":[{"name":"6Ontario Institute for Cancer Research, Toronto, Ontario;"},{"name":"7Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, Toronto, Ontario;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Domecq","sequence":"additional","affiliation":[{"name":"2Research Institute of the McGill University Health Centre, Montreal, Quebec;"},{"name":"3Rosalind and Morris Goodman Cancer Institute,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryn","family":"Golesworthy","sequence":"additional","affiliation":[{"name":"2Research Institute of the McGill University Health Centre, Montreal, Quebec;"},{"name":"3Rosalind and Morris Goodman Cancer Institute,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaya","family":"Shwaartz","sequence":"additional","affiliation":[{"name":"7Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, Toronto, Ontario;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayelet","family":"Borgida","sequence":"additional","affiliation":[{"name":"8Ontario Pancreas Cancer Study, Mount Sinai Hospital, Toronto, Ontario;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spring","family":"Holter","sequence":"additional","affiliation":[{"name":"6Ontario Institute for Cancer Research, Toronto, Ontario;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie M.","family":"Wilson","sequence":"additional","affiliation":[{"name":"6Ontario Institute for Cancer Research, Toronto, Ontario;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Chong","sequence":"additional","affiliation":[{"name":"9Molecular Diagnostics Laboratory, Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grainne M.","family":"O\u2019Kane","sequence":"additional","affiliation":[{"name":"7Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, Toronto, Ontario;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer J.","family":"Knox","sequence":"additional","affiliation":[{"name":"7Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, Toronto, Ontario;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra E.","family":"Fischer","sequence":"additional","affiliation":[{"name":"10Department of Pathology, University of Toronto, Ontario; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Gallinger","sequence":"additional","affiliation":[{"name":"6Ontario Institute for Cancer Research, Toronto, Ontario;"},{"name":"7Wallace McCain Centre for Pancreatic Cancer, Princess Margaret Cancer Centre, Toronto, Ontario;"},{"name":"8Ontario Pancreas Cancer Study, Mount Sinai Hospital, Toronto, Ontario;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zu-Hua","family":"Gao","sequence":"additional","affiliation":[{"name":"11Department of Pathology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D.","family":"Foulkes","sequence":"additional","affiliation":[{"name":"2Research Institute of the McGill University Health Centre, Montreal, Quebec;"},{"name":"12Department of Human Genetics, and"},{"name":"13Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin A.","family":"Waschke","sequence":"additional","affiliation":[{"name":"4Division of Gastroenterology and Hepatology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Zogopoulos","sequence":"additional","affiliation":[{"name":"1Department of Surgery, McGill University, Montreal, Quebec;"},{"name":"2Research Institute of the McGill University Health Centre, Montreal, Quebec;"},{"name":"3Rosalind and Morris Goodman Cancer Institute,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4047","reference":[{"key":"ref941","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.pan.2021.01.017","article-title":"Guidelines on management of pancreatic cysts detected in high-risk individuals: an evaluation of the 2017 Fukuoka guidelines and the 2020 International Cancer of the Pancreas Screening (CAPS) Consortium statements","volume":"21","author":"Dbouk","year":"2021","journal-title":"Pancreatology"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.cgh.2006.02.005","article-title":"Screening for early pancreatic neoplasia in high-risk individuals: a prospective controlled study","volume":"4","author":"Canto","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref961","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jamcollsurg.2014.11.029","article-title":"GNAS and KRAS mutations define separate progression pathways in intraductal papillary mucinous neoplasm-associated carcinoma","volume":"220","author":"Tan","year":"2015","journal-title":"J Am Coll Surg"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/ajg.2018.14","article-title":"ACG clinical guideline: diagnosis and management of pancreatic cysts","volume":"113","author":"Elta","year":"2018","journal-title":"Am J Gastroenterol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1053\/j.seminoncol.2016.09.002","article-title":"Familial pancreatic cancer","volume":"43","author":"Petersen","year":"2016","journal-title":"Semin Oncol"},{"key":"ref501","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/00000478-200407000-00001","article-title":"Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an \u201cintestinal\u201d pathway of carcinogenesis in the pancreas","volume":"28","author":"Adsay","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"ref581","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/ajg.2014.435","article-title":"American College of Gastroenterology. ACG clinical guideline: genetic testing and management of hereditary gastrointestinal cancer syndromes","volume":"110","author":"Syngal","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"ref431","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00428-015-1751-6","article-title":"GNAS mutation is a frequent event in pancreatic intraductal papillary mucinous neoplasms and associated adenocarcinomas","volume":"466","author":"Hosoda","year":"2015","journal-title":"Virchows Arch"},{"key":"ref1021","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/00000478-200407000-00001","article-title":"Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an \u201cintestinal\u201d pathway of carcinogenesis in the pancreas","volume":"28","author":"Adsay","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1001\/jama.2019.10232","article-title":"Screening for pancreatic cancer: U.S. Preventive Services Task Force reaffirmation recommendation statement","volume":"322","author":"Owens","year":"2019","journal-title":"JAMA"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1186\/s13104-015-1803-7","article-title":"A cancer cell-line titration series for evaluating somatic classification","volume":"8","author":"Denroche","year":"2015","journal-title":"BMC Res Notes"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"key":"ref691","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1186\/s13104-015-1803-7","article-title":"A cancer cell-line titration series for evaluating somatic 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Surg"},{"key":"ref531","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa1304369","article-title":"Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine","volume":"369","author":"Von Hoff","year":"2013","journal-title":"N Engl J Med"},{"key":"ref821","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/MPA.0000000000000725","article-title":"Prevalence and progression of pancreatic cystic precursor lesions differ between groups at high risk of developing pancreatic cancer","volume":"46","author":"Konings","year":"2017","journal-title":"Pancreas"},{"key":"ref891","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1136\/gutjnl-2018-318059","article-title":"Kras and Lkb1 mutations synergistically induce intraductal papillary mucinous neoplasm derived from pancreatic duct cells","volume":"69","author":"Collet","year":"2020","journal-title":"Gut"},{"key":"ref971","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1053\/j.gastro.2018.10.029","article-title":"Pathways of progression from intraductal papillary mucinous neoplasm to pancreatic ductal adenocarcinoma based on molecular features","volume":"156","author":"Omori","year":"2019","journal-title":"Gastroenterology"},{"key":"ref541","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1001\/jama.2019.10232","article-title":"Screening for pancreatic cancer: U.S. Preventive Services Task Force reaffirmation recommendation statement","volume":"322","author":"Owens","year":"2019","journal-title":"JAMA"},{"key":"ref811","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1097\/MPA.0000000000000052","article-title":"Promising outcomes of screening for pancreatic cancer by genetic testing and endoscopic ultrasound","volume":"43","author":"Sud","year":"2014","journal-title":"Pancreas"},{"key":"ref911","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/bjs5.50180","article-title":"Surveillance for pancreatic cancer in high-risk individuals","volume":"3","author":"Konings","year":"2019","journal-title":"BJS Open"},{"key":"ref1011","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/ng.3659","article-title":"Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance","volume":"48","author":"Secrier","year":"2016","journal-title":"Nat Genet"},{"key":"ref381","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.pan.2021.04.009","article-title":"Systematic review and meta-analysis of observational studies on BD-IPMNS progression to malignancy","volume":"21","author":"Balduzzi","year":"2021","journal-title":"Pancreatology"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jmoldx.2016.04.002","article-title":"Clinical next-generation sequencing pipeline outperforms a combined approach using Sanger sequencing and multiplex ligation-dependent probe amplification in targeted gene panel analysis","volume":"18","author":"Schenkel","year":"2016","journal-title":"J Mol Diagn"},{"key":"ref561","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1053\/j.seminoncol.2016.09.002","article-title":"Familial pancreatic cancer","volume":"43","author":"Petersen","year":"2016","journal-title":"Semin Oncol"},{"key":"ref491","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/ng.3659","article-title":"Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance","volume":"48","author":"Secrier","year":"2016","journal-title":"Nat Genet"},{"key":"ref871","article-title":"Long-term yield of pancreatic cancer surveillance in high-risk individuals [published online April 5, 2021]","author":"Overbeek","journal-title":"Gut"},{"key":"ref731","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nature19823","article-title":"A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns","volume":"538","author":"Notta","year":"2016","journal-title":"Nature"},{"key":"ref721","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.gie.2008.07.043","article-title":"EUS-based criteria for the diagnosis of chronic pancreatitis: the Rosemont classification","volume":"69","author":"Catalano","year":"2009","journal-title":"Gastrointest Endosc"},{"key":"ref831","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1053\/j.gastro.2018.05.035","article-title":"Risk of neoplastic progression in individuals at high risk for pancreatic cancer undergoing long-term surveillance","volume":"155","author":"Canto","year":"2018","journal-title":"Gastroenterology"},{"key":"ref681","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1158\/1078-0432.CCR-17-2994","article-title":"Genomics-driven precision medicine for advanced pancreatic cancer: early results from the COMPASS Trial","volume":"24","author":"Aung","year":"2018","journal-title":"Clin Cancer Res"},{"key":"ref481","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/ng.3357","article-title":"Whole-genome sequencing provides new insights into the clonal architecture of Barrett\u2019s esophagus and esophageal adenocarcinoma","volume":"47","author":"Ross-Innes","year":"2015","journal-title":"Nat Genet"},{"key":"ref471","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00000478-200101000-00003","article-title":"Colloid (mucinous noncystic) carcinoma of the pancreas","volume":"25","author":"Adsay","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"ref751","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1093\/carcin\/bgt068","article-title":"Identification of molecular alterations in gastrointestinal carcinomas and dysplastic hamartomas in Peutz-Jeghers syndrome","volume":"34","author":"Korsse","year":"2013","journal-title":"Carcinogenesis"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1177\/2050640617752182","article-title":"Results of surveillance in individuals at high-risk of pancreatic cancer: a systematic review and meta-analysis","volume":"6","author":"Signoretti","year":"2018","journal-title":"United European Gastroenterol J"},{"key":"ref351","article-title":"Long-term yield of pancreatic cancer surveillance in high-risk individuals [published online April 5, 2021]","author":"Overbeek","journal-title":"Gut"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.pan.2021.01.017","article-title":"Guidelines on management of pancreatic cysts detected in high-risk individuals: an evaluation of the 2017 Fukuoka guidelines and the 2020 International Cancer of the Pancreas Screening (CAPS) Consortium statements","volume":"21","author":"Dbouk","year":"2021","journal-title":"Pancreatology"},{"key":"ref761","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S1542-3565(04)00244-7","article-title":"Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach","volume":"2","author":"Canto","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref951","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00428-015-1751-6","article-title":"GNAS mutation is a frequent event in pancreatic intraductal papillary mucinous neoplasms and associated 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Oncol"},{"key":"ref981","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.gie.2018.08.029","article-title":"Chronic pancreatitis changes in high-risk individuals for pancreatic ductal adenocarcinoma","volume":"89","author":"Thiruvengadam","year":"2019","journal-title":"Gastrointest Endosc"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1158\/1078-0432.CCR-17-2994","article-title":"Genomics-driven precision medicine for advanced pancreatic cancer: early results from the COMPASS Trial","volume":"24","author":"Aung","year":"2018","journal-title":"Clin Cancer Res"},{"key":"ref861","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.gie.2017.12.019","article-title":"Pancreatic cancer screening in high-risk individuals with germline genetic mutations","volume":"87","author":"DaVee","year":"2018","journal-title":"Gastrointest 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Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"ref711","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1503\/cjs.026409","article-title":"Management of pancreatic adenocarcinoma in Ontario, Canada: a population-based study using novel case ascertainment","volume":"54","author":"Borgida","year":"2011","journal-title":"Can J Surg"},{"key":"ref791","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s11605-011-1781-6","article-title":"Screening for pancreatic cancer in a high-risk cohort: an eight-year experience","volume":"16","author":"Al-Sukhni","year":"2012","journal-title":"J Gastrointest Surg"},{"key":"ref621","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3747\/co.22.2300","article-title":"Establishing a clinic-based pancreatic cancer and periampullary tumour research registry in Quebec","volume":"22","author":"Smith","year":"2015","journal-title":"Curr 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asymptomatic high-risk individuals","volume":"142","author":"Canto","year":"2012","journal-title":"Gastroenterology"},{"key":"ref881","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/S0002-9440(10)63053-2","article-title":"STK11\/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas","volume":"159","author":"Sato","year":"2001","journal-title":"Am J Pathol"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.gie.2017.12.019","article-title":"Pancreatic cancer screening in high-risk individuals with germline genetic mutations","volume":"87","author":"DaVee","year":"2018","journal-title":"Gastrointest Endosc"},{"key":"ref601","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cgh.2018.04.065","article-title":"Diagnostic yield from screening asymptomatic individuals at high risk for pancreatic cancer: a meta-analysis of cohort studies","volume":"17","author":"Corral","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref921","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000090023","article-title":"International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas","volume":"6","author":"Tanaka","year":"2006","journal-title":"Pancreatology"},{"key":"ref571","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1158\/0008-5472.CAN-03-3823","article-title":"Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds","volume":"64","author":"Klein","year":"2004","journal-title":"Cancer Res"},{"key":"ref741","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/cancers9050042","article-title":"KRAS, TP53, CDKN2A, SMAD4, BRCA1, and BRCA2 mutations in pancreatic cancer","volume":"9","author":"Cicenas","year":"2017","journal-title":"Cancers (Basel)"},{"key":"ref1001","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/ng.3357","article-title":"Whole-genome sequencing provides new insights into the clonal architecture of Barrett\u2019s esophagus and esophageal adenocarcinoma","volume":"47","author":"Ross-Innes","year":"2015","journal-title":"Nat Genet"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10689-017-0057-z","article-title":"Development of a high risk pancreatic screening clinic using 3.0 T MRI","volume":"17","author":"Barnes","year":"2018","journal-title":"Fam Cancer"},{"key":"ref771","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.cgh.2006.02.005","article-title":"Screening for early pancreatic neoplasia in high-risk individuals: a prospective controlled study","volume":"4","author":"Canto","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref441","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jamcollsurg.2014.11.029","article-title":"GNAS and KRAS mutations define separate progression pathways in intraductal papillary mucinous neoplasm-associated carcinoma","volume":"220","author":"Tan","year":"2015","journal-title":"J Am Coll Surg"},{"key":"ref991","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00000478-200101000-00003","article-title":"Colloid (mucinous noncystic) carcinoma of the pancreas","volume":"25","author":"Adsay","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa1304369","article-title":"Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine","volume":"369","author":"Von Hoff","year":"2013","journal-title":"N Engl J Med"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1158\/0008-5472.CAN-03-3823","article-title":"Prospective 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interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"ref511","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1200\/JCO.18.01512","article-title":"Deleterious germline mutations are a risk factor for neoplastic progression among high-risk individuals undergoing pancreatic surveillance","volume":"37","author":"Abe","year":"2019","journal-title":"J Clin Oncol"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.gie.2008.07.043","article-title":"EUS-based criteria for the diagnosis of chronic pancreatitis: the Rosemont classification","volume":"69","author":"Catalano","year":"2009","journal-title":"Gastrointest Endosc"},{"key":"ref521","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21551","article-title":"Cancer statistics, 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College of Gastroenterology. 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