{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:42:20Z","timestamp":1790653340985,"version":"4.1.0"},"reference-count":84,"publisher":"Harborside Press, LLC","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> We sought to identify the absolute risk of specific HPV genotype for cervical intraepithelial neoplasia grade 2\/3 or worse (CIN2+\/3+) and to develop a risk-based management strategy in an HPV-positive population. <jats:bold>Methods:<\/jats:bold> HPV genotyping was performed based on a 3-year cervical cancer screening cohort. The study endpoints were histologic CIN2+\/3+. The prevalence of specific HPV genotype was calculated by minimum, any type, and hierarchical attribution estimate. The absolute CIN2+\/3+ risks of specific HPV genotype were estimated and risk-based management strategy was established according to the American Society for Colposcopy and Cervical Pathology guideline. The efficacy of conventional and risk-based management strategies for non-16\/18 HPVs were further evaluated. <jats:bold>Results:<\/jats:bold> Eligible data were available for 8,370 women with a median age of 48 years (interquartile range, 42\u201353 years). At baseline, there were 1,062 women with HPV-positive disease, including 424 with multiple and 639 with single infections. CIN2+\/3+ cases represented 113\/74, 23\/8, 20\/7, and 52\/31 patients at baseline and first-, second-, and third-year visits, respectively. Women with multiple HPV infections at baseline were more prone to persistent infection than those with single infection (<jats:italic>P<\/jats:italic>&lt;.0001). HPV16 and HPV52 were the top 2 ranking among baseline and 3-year cumulative CIN2+\/3+ cases. Based on the absolute risk of specific HPV genotype combined with cytology for CIN2+\/3+, all non-16\/18 HPVs were divided into 4 risk-stratified groups. Compared with conventional strategy, the risk-based strategy had higher specificity (<jats:italic>P<\/jats:italic>=.0000) and positive predictive value (<jats:italic>P<\/jats:italic>=.0322) to detect CIN3+ and needed fewer colposcopies for each CIN3+ case. <jats:bold>Conclusions:<\/jats:bold> Based on our study findings, we propose a new extended HPV genotyping protocol, which would provide a better strategy for achieving precise risk-based management of HPV-positive populations.<\/jats:p>","DOI":"10.6004\/jnccn.2022.7032","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T19:36:04Z","timestamp":1660160164000},"page":"906-914.e10","source":"Crossref","is-referenced-by-count":19,"title":["Extended HPV Genotyping for Risk Assessment of Cervical Intraepithelial Neoplasia Grade 2\/3 or Worse in a Cohort Study"],"prefix":"10.6004","volume":"20","author":[{"given":"Xiao","family":"Li","sequence":"first","affiliation":[{"name":"1Department of Gynecologic Oncology, Women\u2019s Hospital, Zhejiang University School of Medicine;"},{"name":"2Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases of Zhejiang Province;"},{"name":"3Cancer Research Institute of Zhejiang University; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Rao","sequence":"additional","affiliation":[{"name":"1Department of Gynecologic Oncology, Women\u2019s Hospital, Zhejiang University School of Medicine;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Jing","family":"Wei","sequence":"additional","affiliation":[{"name":"1Department of Gynecologic Oncology, Women\u2019s Hospital, Zhejiang University School of Medicine;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Guo","family":"Lu","sequence":"additional","affiliation":[{"name":"1Department of Gynecologic Oncology, Women\u2019s Hospital, Zhejiang University School of Medicine;"},{"name":"3Cancer Research Institute of Zhejiang University; and"},{"name":"4Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Hangzhou, Zhejiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Xie","sequence":"additional","affiliation":[{"name":"1Department of Gynecologic Oncology, Women\u2019s Hospital, Zhejiang University School of Medicine;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"1Department of Gynecologic Oncology, Women\u2019s Hospital, Zhejiang University School of Medicine;"},{"name":"3Cancer Research Institute of Zhejiang University; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4047","reference":[{"key":"ref351","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/sj.bjc.6601024","article-title":"Comparison of HPV type distribution in high-grade cervical lesions and cervical cancer: a 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