{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:01:49Z","timestamp":1793088109538,"version":"4.5.0"},"reference-count":108,"publisher":"Harborside Press, LLC","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold>Polypharmacy and potentially inappropriate medications (PIMs) are common among older adults with blood cancers, but their association with frailty and how to manage them optimally remain unclear.<jats:bold>Patients and Methods:<\/jats:bold>From 2015 to 2019, patients aged \u226575 years presenting for initial oncology consult underwent screening geriatric assessment. Patients were determined to be robust, prefrail, or frail via deficit accumulation and phenotypic approaches. We quantified each patient\u2019s total number of medications and PIMs using the Anticholinergic Risk Scale (ARS) and a scale we generated using the NCCN Medications of Concern called the<jats:italic>Geriatric Oncology Potentially Inappropriate Medications<\/jats:italic>(GO-PIM) scale. We assessed cross-sectional associations of PIMs with frailty in multivariable regression models adjusting for age, gender, and comorbidity.<jats:bold>Results:<\/jats:bold>Of 785 patients assessed, 603 (77%) were taking \u22655 medications and 421 (54%) were taking \u22658 medications; 201 (25%) were taking at least 1 PIM based on the ARS and 343 (44%) at least 1 PIM based on the GO-PIM scale. Among the 468 (60%) patients on active cancer treatment, taking \u22658 medications was associated with frailty (adjusted odds ratio [aOR], 2.82; 95% CI, 1.92\u20134.17). With each additional medication, the odds of being prefrail or frail increased 8% (aOR, 1.08; 95% CI, 1.04\u20131.12). With each 1-point increase on the ARS, the odds of being prefrail or frail increased 19% (aOR, 1.19; 95% CI, 1.03\u20131.39); with each additional PIM based on the GO-PIM scale, the odds increased 65% (aOR, 1.65; 95% CI, 1.34\u20132.04).<jats:bold>Conclusions:<\/jats:bold>Polypharmacy and PIMs are prevalent among older patients with blood cancers; taking \u22658 medications is strongly associated with frailty. These data suggest careful medication reconciliation for this population may be helpful, and deprescribing when possible is high-yield, especially for PIMs on the GO-PIM scale.<\/jats:p>","DOI":"10.6004\/jnccn.2022.7033","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T19:36:04Z","timestamp":1660160164000},"page":"915-923.e5","source":"Crossref","is-referenced-by-count":24,"title":["Association of Polypharmacy and Potentially Inappropriate Medications With Frailty Among Older Adults With Blood Cancers"],"prefix":"10.6004","volume":"20","author":[{"given":"Tammy T.","family":"Hshieh","sequence":"first","affiliation":[{"name":"1Division of Aging, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, Massachusetts;"},{"name":"2Harvard Medical School, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clark","family":"DuMontier","sequence":"additional","affiliation":[{"name":"1Division of Aging, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, Massachusetts;"},{"name":"2Harvard Medical School, Boston, Massachusetts;"},{"name":"3New England Geriatric Research Education and Clinical Center, Bedford, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Jaung","sequence":"additional","affiliation":[{"name":"3New England Geriatric Research Education and Clinical Center, Bedford, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nupur E.","family":"Bahl","sequence":"additional","affiliation":[{"name":"3New England Geriatric Research Education and Clinical Center, Bedford, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea E.","family":"Hawley","sequence":"additional","affiliation":[{"name":"3New England Geriatric Research Education and Clinical Center, Bedford, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Mozessohn","sequence":"additional","affiliation":[{"name":"4Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Stone","sequence":"additional","affiliation":[{"name":"2Harvard Medical School, Boston, Massachusetts;"},{"name":"5Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Soiffer","sequence":"additional","affiliation":[{"name":"2Harvard Medical School, Boston, Massachusetts;"},{"name":"5Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A.","family":"Driver","sequence":"additional","affiliation":[{"name":"1Division of Aging, Department of Medicine, Brigham and Women\u2019s Hospital, Boston, Massachusetts;"},{"name":"2Harvard Medical School, Boston, Massachusetts;"},{"name":"5Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Abel","sequence":"additional","affiliation":[{"name":"2Harvard Medical School, Boston, Massachusetts;"},{"name":"5Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4047","reference":[{"key":"ref581","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jgo.2020.07.010","article-title":"Impact of a pharmacist and geriatrician medication review on drug-related problems in older outpatients with cancer","volume":"12","author":"Choukroun","year":"2021","journal-title":"J Geriatr Oncol"},{"key":"ref471","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.leukres.2014.06.018","article-title":"The prognostic importance of polypharmacy in older adults treated for acute myelogenous leukemia (AML)","volume":"38","author":"Elliot","year":"2014","journal-title":"Leuk Res"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.jgo.2020.12.007","article-title":"Interventions to reduce polypharmacy and optimize medication use in older adults with cancer","volume":"12","author":"Barlow","year":"2021","journal-title":"J Geriatr Oncol"},{"key":"ref771","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1111\/bcp.13590","article-title":"The relationship between frailty and polypharmacy in older people: a systematic review","volume":"84","author":"Guti\u00e9rrez-Valencia","year":"2018","journal-title":"Br J Clin Pharmacol"},{"key":"ref591","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1177\/1078155219851550","article-title":"Polypharmacy and potentially inappropriate medication use is highly prevalent in multiple myeloma patients and is improved by a collaborative physician-pharmacist clinic","volume":"26","author":"Sweiss","year":"2020","journal-title":"J Oncol Pharm Pract"},{"key":"ref1081","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/bjh.15027","article-title":"Potentially inappropriate medication use in elderly non-Hodgkin lymphoma patients is associated with reduced survival and increased toxicities","volume":"180","author":"Lin","year":"2018","journal-title":"Br J Haematol"},{"key":"ref561","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1111\/j.1532-5415.2008.01737.x","article-title":"Anticholinergic activity of 107 medications commonly used by older adults","volume":"56","author":"Chew","year":"2008","journal-title":"J Am Geriatr Soc"},{"key":"ref731","doi-asserted-by":"crossref","first-page":"267","DOI":"10.6004\/jnccn.2020.7628","article-title":"Association of polypharmacy and potentially inappropriate medications with physical functional impairments in older adults with cancer","volume":"19","author":"Mohamed","year":"2021","journal-title":"J Natl Compr Canc Netw"},{"key":"ref431","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1080\/10428194.2020.1737687","article-title":"Prevalence and effects of polypharmacy on overall survival in acute myeloid leukemia","volume":"61","author":"Dhakal","year":"2020","journal-title":"Leuk Lymphoma"},{"key":"ref801","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s40801-021-00256-5","article-title":"Associations between anticholinergic medication exposure and adverse health outcomes in older people with frailty: a systematic review and meta-analysis","volume":"8","author":"Mehdizadeh","year":"2021","journal-title":"Drugs Real World 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assessment and management on the toxic effects of cancer treatment (GAP70+): a cluster-randomised study","volume":"398","author":"Mohile","year":"2021","journal-title":"Lancet"},{"key":"ref1241","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/S0140-6736(21)01789-X","article-title":"Evaluation of geriatric assessment and management on the toxic effects of cancer treatment (GAP70+): a cluster-randomised study","volume":"398","author":"Mohile","year":"2021","journal-title":"Lancet"},{"key":"ref751","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1001\/archinternmed.2007.106","article-title":"The anticholinergic risk scale and anticholinergic adverse effects in older persons","volume":"168","author":"Rudolph","year":"2008","journal-title":"Arch Intern Med"},{"key":"ref541","first-page":"1295","article-title":"Steroids as pain relief adjuvants","volume":"56","author":"Vyvey","year":"2010","journal-title":"Can Fam 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cancer","volume":"33","author":"Nightingale","year":"2015","journal-title":"J Clin Oncol"},{"key":"ref381","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2147\/CLEP.S47150","article-title":"The impact of comorbidity on cancer survival: a review","volume":"5","author":"S\u00f8gaard","year":"2013","journal-title":"Clin Epidemiol"},{"key":"ref981","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"ref401","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2020.38.29_suppl.118","article-title":"The association of polypharmacy with functional status impairment, frailty, and health-related quality of life in older adults with gastrointestinal malignancy: results from the Cancer and Aging Resilience Evaluation (CARE) registry 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