{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T19:27:13Z","timestamp":1777836433303,"version":"3.51.4"},"reference-count":13,"publisher":"Harborside Press, LLC","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>This report describes the management of small cell lung cancer (SCLC) transformation in a patient with untreated <jats:italic>ALK<\/jats:italic>-mutated advanced disease and a minimal smoking history, and a separate case of a de novo SCLC in a lifelong nonsmoker found to have a potentially targetable <jats:italic>ERBB2<\/jats:italic> alteration. In the first case, chemotherapy followed by a targeted inhibitor was chosen due to the presence of the <jats:italic>ALK<\/jats:italic> rearrangement, as well as a somewhat discordant response to induction chemotherapy, suggesting possible progression of the <jats:italic>ALK<\/jats:italic> inhibitor\u2013sensitive component. Molecular testing for the identification of driver mutations should be considered in patients with SCLC who have light\/never smoking histories in order to help understand the incidence and ultimate optimal management strategies.<\/jats:p>","DOI":"10.6004\/jnccn.2022.7089","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T16:01:38Z","timestamp":1676476898000},"page":"336-339","source":"Crossref","is-referenced-by-count":5,"title":["Small Cell Lung Cancer in Light\/Never Smokers \u2013 A Role for Molecular Testing?"],"prefix":"10.6004","volume":"21","author":[{"given":"Gordon Taylor","family":"Moffat","sequence":"first","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Queen\u2019s University, Kingston, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Queen\u2019s University, Kingston, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew G.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Queen\u2019s University, Kingston, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4047","reference":[{"key":"B1","series-title":"CA Cancer J Clin","first-page":"7","article-title":"Cancer statistics, 2021","volume":"71","author":"Siegel RL","year":"2021","unstructured":"Siegel RL, Miller KD, Fuchs HE,  Cancer statistics, 2021. 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