{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T18:42:40Z","timestamp":1769625760357,"version":"3.49.0"},"reference-count":39,"publisher":"Harborside Press, LLC","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> CAR T-cell therapy has transformed the treatment of hematologic malignancies, but it is complex and challenging to convey to patients. Educational video interventions are efficacious for improving patient knowledge about cancer therapeutics and informing their care preferences, yet no educational videos have been evaluated in CAR T-cell therapy. <jats:bold>Methods:<\/jats:bold> We conducted a randomized controlled trial comparing an educational video versus usual care in adults (age \u226518 years) with hematologic malignancies receiving CAR T-cell therapy at Massachusetts General Hospital. Intervention participants watched a 13-minute video depicting how CAR T-cell therapy works, logistics, toxicities, prognosis, recovery, and approaches for dealing with prognostic uncertainty. The primary outcome was feasibility (\u226560% enrollment rate). Secondary outcomes included acceptability (\u226580% reporting comfort with the video), patients\u2019 knowledge about CAR T-cell therapy (10-item test), and self-efficacy (Communication and Attitudinal Self-Efficacy Scale\u2013Cancer), decision satisfaction (Decision Conflict Scale), psychological distress (Hospital Anxiety and Depression Scale), and preference for CAR T-cell therapy. <jats:bold>Results:<\/jats:bold> We enrolled 79% (80\/101) of eligible patients. Of that group, 91% (30\/33) reported being very or somewhat comfortable watching the video, and 94% (31\/33) would definitely or probably recommend the video. At 1 month, participants in the video arm reported higher self-efficacy (mean difference [MD], 9.2 [95% CI, \u20134.0 to 22.3]; Cohen\u2019s <jats:italic>d<\/jats:italic>, 0.32), decision satisfaction (MD, 2.5 [95% CI, 0.7\u20134.2]; Cohen\u2019s <jats:italic>d<\/jats:italic>, 0.67), and lower anxiety (MD, \u20130.8 [95% CI, \u20132.5 to 0.7]; Cohen\u2019s <jats:italic>d<\/jats:italic>, 0.26) compared with participants in the usual care arm. At 1 week, both arms reported high preferences for CAR T-cell therapy (video arm, 94% [33\/35]; usual care, 84% [27\/32]). <jats:bold>Conclusions:<\/jats:bold> We found that an educational video for patients receiving CAR T-cell therapy was feasible and acceptable. The educational video demonstrated promising preliminary effects on patient self-efficacy and decision satisfaction and warrants further study.<\/jats:p>","DOI":"10.6004\/jnccn.2024.70011","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T14:06:40Z","timestamp":1709042800000},"source":"Crossref","is-referenced-by-count":2,"title":["Pilot Randomized Controlled Trial of an Educational Video for CAR T-Cell Therapy Recipients"],"prefix":"10.6004","volume":"22","author":[{"given":"P. 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