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If achieving negative margins or resection is not feasible, radiation therapy or systemic treatment are options that may be considered by a multidisciplinary team. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) outline recommended treatment options available for DFSP.<\/jats:p>","DOI":"10.6004\/jnccn.2025.0001","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T08:55:39Z","timestamp":1736931339000},"source":"Crossref","is-referenced-by-count":28,"title":["Dermatofibrosarcoma Protuberans, Version 1.2025, NCCN Clinical Practice Guidelines In Oncology"],"prefix":"10.6004","volume":"23","author":[{"given":"Jeremy","family":"Bordeaux","sequence":"first","affiliation":[{"name":"Case Comprehensive Cancer Center\/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Blitzblau","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumaira Z.","family":"Aasi","sequence":"additional","affiliation":[{"name":"Stanford Cancer Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murad","family":"Alam","sequence":"additional","affiliation":[{"name":"Robert H. 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Lyon, France: IARC Press; 2013:77\u201379."},{"key":"B13","first-page":"1630","article-title":"Connective Tissue Tumors","author":"Calonje E","year":"2012","unstructured":"Calonje E, Brenn T, Lazar A, McKee PH. Connective Tissue Tumors. In: Calonje E, Brenn T, Lazar A, McKee PH, eds. McKee\u2019s Pathology of the Skin with Clinical Correlations, 4th ed. Philadelphia, PA: Elsevier Saunders; 2012:1630\u20131635."},{"key":"B14","series-title":"Am J Dermatopathol","first-page":"429","article-title":"CD34 and factor XIIIa in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans","volume":"15","author":"Abenoza P","year":"1993","unstructured":"Abenoza P, Lillemoe T. CD34 and factor XIIIa in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans. 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J Clin Oncol 1996;14:2365\u20132369."},{"key":"B58","series-title":"J BUON","first-page":"268","article-title":"Evaluation of the role of radiotherapy in the management of dermatofibrosarcoma protuberans","volume":"18","author":"Uysal B","year":"2013","unstructured":"Uysal B, Sager O, Gamsiz H,  Evaluation of the role of radiotherapy in the management of dermatofibrosarcoma protuberans. J BUON 2013;18:268\u2013273."},{"key":"B59","series-title":"Indian Dermatol Online J","first-page":"93","article-title":"Outcome of wide local excision in dermatofibrosarcoma protuberans and use of radiotherapy for margin-positive disease","volume":"4","author":"Hamid R","year":"2013","unstructured":"Hamid R, Hafeez A, Darzi MA,  Outcome of wide local excision in dermatofibrosarcoma protuberans and use of radiotherapy for margin-positive disease. 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Am J Clin Oncol 2005;28:537\u2013539."},{"key":"B62","series-title":"Radiother Oncol","first-page":"175","article-title":"Dermatofibrosarcoma protuberans: treatment results of 35 cases","volume":"57","author":"Sun LM","year":"2000","unstructured":"Sun LM, Wang CJ, Huang CC,  Dermatofibrosarcoma protuberans: treatment results of 35 cases. Radiother Oncol 2000;57:175\u2013181."},{"key":"B63","series-title":"Am J Clin Oncol","first-page":"430","article-title":"Radiotherapy for dermatofibrosarcoma protuberans","volume":"37","author":"Williams N","year":"2014","unstructured":"Williams N, Morris CG, Kirwan JM,  Radiotherapy for dermatofibrosarcoma protuberans. Am J Clin Oncol 2014;37:430\u2013432."},{"key":"B64","series-title":"Eur J Cancer","first-page":"1055","article-title":"The role of radiotherapy in the local management of dermatofibrosarcoma protuberans. Soft Tissue Tumours Working Group","volume":"33","author":"Haas RL","year":"1997","unstructured":"Haas RL, Keus RB, Loftus BM,  The role of radiotherapy in the local management of dermatofibrosarcoma protuberans. Soft Tissue Tumours Working Group. Eur J Cancer 1997;33:1055\u20131060."},{"key":"B65","series-title":"J Eur Acad Dermatol Venereol","first-page":"1107","article-title":"The efficacy of adjuvant radiotherapy in dermatofibrosarcoma protuberans: a systemic review and meta-analysis","volume":"30","author":"Chen YT","year":"2016","unstructured":"Chen YT, Tu WT, Lee WR, Huang YC. The efficacy of adjuvant radiotherapy in dermatofibrosarcoma protuberans: a systemic review and meta-analysis. J Eur Acad Dermatol Venereol 2016;30:1107\u20131114."},{"key":"B66","series-title":"Mod Pathol","first-page":"668","article-title":"Detection of COL1A1-PDGFB fusion transcripts and PDGFB\/PDGFRB mRNA expression in dermatofibrosarcoma protuberans","volume":"20","author":"Takahira T","year":"2007","unstructured":"Takahira T, Oda Y, Tamiya S,  Detection of COL1A1-PDGFB fusion transcripts and PDGFB\/PDGFRB mRNA expression in dermatofibrosarcoma protuberans. Mod Pathol 2007;20:668\u2013675."},{"key":"B67","series-title":"Hum Pathol","first-page":"184","article-title":"Dermatofibrosarcoma protuberans COL1A1-PDGFB fusion is identified in virtually all dermatofibrosarcoma protuberans cases when investigated by newly developed multiplex reverse transcription polymerase chain reaction and fluorescence in situ hybridization assays","volume":"39","author":"Patel KU","year":"2008","unstructured":"Patel KU, Szabo SS, Hernandez VS,  Dermatofibrosarcoma protuberans COL1A1-PDGFB fusion is identified in virtually all dermatofibrosarcoma protuberans cases when investigated by newly developed multiplex reverse transcription polymerase chain reaction and fluorescence in situ hybridization assays. Hum Pathol 2008;39:184\u2013193."},{"key":"B68","series-title":"Nat Genet","first-page":"95","article-title":"Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma","volume":"15","author":"Simon MP","year":"1997","unstructured":"Simon MP, Pedeutour F, Sirvent N,  Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Nat Genet 1997;15:95\u201398."},{"key":"B69","series-title":"J Clin Oncol","first-page":"1772","article-title":"Imatinib mesylate in advanced dermatofibrosarcoma protuberans: pooled analysis of two phase II clinical trials","volume":"28","author":"Rutkowski P","year":"2010","unstructured":"Rutkowski P, Van Glabbeke M, Rankin CJ,  Imatinib mesylate in advanced dermatofibrosarcoma protuberans: pooled analysis of two phase II clinical trials. 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