{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T07:54:39Z","timestamp":1778140479860,"version":"3.51.4"},"reference-count":56,"publisher":"Harborside Press, LLC","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> With advances in antiretroviral therapy, aging people with HIV (PWH) are increasingly at risk for non\u2013AIDS-defining cancers (NADCs) and chronic morbidities. This study examines whether PWH with NADCs face a higher risk of new-onset chronic health conditions compared with those without cancer. <jats:bold>Patients and Methods:<\/jats:bold> We conducted a retrospective cohort study using data from the CFAR (Centers for AIDS Research) Network of Integrated Clinical Systems (CNICS) for PWH enrolled between 1995 and 2018 from 8 US academic institutions. We included PWH with the 5 most common NADCs: anal cancer, non\u2013small cell lung cancer (NSCLC), prostate cancer, classic Hodgkin lymphoma (HL), and hepatocellular carcinoma (HCC). A 1:2 matching for each NADC subgroup was performed based on age, cohort entry year, and sex (noncancer cohort). Chronic health conditions were graded using the CTCAE, with the primary outcome being the risk of new-onset grade \u22653 morbidities, analyzed using Cox regression. <jats:bold>Results:<\/jats:bold> The study included 693 PWH with NADCs and 1,345 matched PWH without cancer. At a median follow-up of 13.7 years for PWH with NADCs and 10.7 years for the noncancer group, the prevalence of grade \u22653 morbidities was significantly higher in the NADC group (24.8% vs 13.8%; <jats:italic>P<\/jats:italic>\u2264.01). Multivariable Cox regression showed a higher risk of new-onset grade \u22653 conditions in the NADC group (hazard ratio, 2.94; <jats:italic>P<\/jats:italic>&lt;.0001), specifically diabetes mellitus (all NADCs), myocardial infarction (NSCLC and HL), and congestive heart failure (prostate cancer). <jats:bold>Conclusions:<\/jats:bold> Our study showed an excess risk of new-onset morbidities among PWH with NADCs. These findings have critical implications for the care of survivors of HIV and cancer and underscore the importance of integrated care approaches to address late effects in this vulnerable population.<\/jats:p>","DOI":"10.6004\/jnccn.2025.7018","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T13:46:15Z","timestamp":1749476775000},"source":"Crossref","is-referenced-by-count":2,"title":["Burden of Chronic Health Conditions Among People With HIV and Common Non\u2013AIDS-Defining Cancers"],"prefix":"10.6004","volume":"23","author":[{"given":"Gaurav","family":"Goyal","sequence":"first","affiliation":[{"name":"Division of Hematology-Oncology, University of Alabama at Birmingham, Birmingham, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ene M.","family":"Enogela","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greer A.","family":"Burkholder","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari M.","family":"Kitahata","sequence":"additional","affiliation":[{"name":"Division of Allergy & Infectious Diseases, University of Washington School of Medicine, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi M.","family":"Crane","sequence":"additional","affiliation":[{"name":"Division of Allergy & Infectious Diseases, University of Washington School of Medicine, Seattle, WA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Eulo","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, University of Alabama at Birmingham, Birmingham, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad J.","family":"Achenbach","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Northwestern University, Chicago, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire E.","family":"Farel","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter W.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of California San Francisco, San Francisco, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Case Western Reserve University, Cleveland, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Fleming","sequence":"additional","affiliation":[{"name":"Infectious Disease, Fenway Health, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward R.","family":"Cachay","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of California San Diego, San Diego, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Saag","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smita","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Richman","sequence":"additional","affiliation":[{"name":"Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4047","reference":[{"key":"B1","series-title":"AIDS","first-page":"123","article-title":"The effect of combined antiretroviral therapy on the overall mortality of HIV-infected individuals","volume":"24","author":"Ray M","year":"2010","unstructured":"Ray M, Logan R, Sterne JAC,  The effect of combined antiretroviral therapy on the overall mortality of HIV-infected individuals. AIDS 2010;24:123\u2013137."},{"key":"B2","series-title":"Ann Intern Med","first-page":"749","article-title":"Update of survival for persons with HIV infection in Denmark","volume":"165","author":"Lohse N","year":"2016","unstructured":"Lohse N, Obel N. Update of survival for persons with HIV infection in Denmark. Ann Intern Med 2016;165:749\u2013750."},{"key":"B3","article-title":"HIV Surveillance Report: Diagnoses of HIV Infection in the United States and Dependent Areas, 2019","unstructured":"Centers for Disease Control and Prevention. HIV Surveillance Report: Diagnoses of HIV Infection in the United States and Dependent Areas, 2019. Accessed February 28, 2025. Available at: https:\/\/stacks.cdc.gov\/view\/cdc\/149036"},{"key":"B4","series-title":"Br J Cancer","first-page":"416","article-title":"Changing patterns of cancer incidence in the early- and late-HAART periods: the Swiss HIV Cohort Study","volume":"103","author":"Franceschi S","year":"2010","unstructured":"Franceschi S, Lise M, Clifford GM,  Changing patterns of cancer incidence in the early- and late-HAART periods: the Swiss HIV Cohort Study. Br J Cancer 2010;103:416\u2013422."},{"key":"B5","series-title":"Lancet","first-page":"59","article-title":"Incidence of cancers in people with HIV\/AIDS compared with immunosuppressed transplant recipients: a meta-analysis","volume":"370","author":"Grulich AE","year":"2007","unstructured":"Grulich AE, van Leeuwen MT, Falster MO, Vajdic CM. Incidence of cancers in people with HIV\/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet 2007;370:59\u201367."},{"key":"B6","series-title":"J Infect Dis","first-page":"1525","article-title":"Comorbidities among US patients with prevalent HIV infection\u2014a trend analysis","volume":"216","author":"Gallant J","year":"2017","unstructured":"Gallant J, Hsue PY, Shreay S, Meyer N. Comorbidities among US patients with prevalent HIV infection\u2014a trend analysis. J Infect Dis 2017;216:1525\u20131533."},{"key":"B7","series-title":"Nat Rev Neurol","first-page":"234","article-title":"HIV-associated neurocognitive disorder\u2013pathogenesis and prospects for treatment","volume":"12","author":"Saylor D","year":"2016","unstructured":"Saylor D, Dickens AM, Sacktor N,  HIV-associated neurocognitive disorder\u2013pathogenesis and prospects for treatment. Nat Rev Neurol 2016;12:234\u2013248."},{"key":"B8","series-title":"HIV Clin Trials","first-page":"100","article-title":"Aging and HIV infection: a comparison between older HIV-infected persons and the general population","volume":"11","author":"Onen NF","year":"2010","unstructured":"Onen NF, Overton ET, Seyfried W,  Aging and HIV infection: a comparison between older HIV-infected persons and the general population. HIV Clin Trials 2010;11:100\u2013109."},{"key":"B9","series-title":"EClinicalMedicine","first-page":"101392.","article-title":"Health conditions in adults with HIV compared with the general population: a population-based cross-sectional analysis","volume":"47","author":"Morales DR","year":"2022","unstructured":"Morales DR, Moreno-Martos D, Matin N, McGettigan P. Health conditions in adults with HIV compared with the general population: a population-based cross-sectional analysis. EClinicalMedicine 2022;47:101392."},{"key":"B10","series-title":"JAMA","first-page":"844","article-title":"Ending the HIV epidemic: a plan for the United States","volume":"321","author":"Fauci AS","year":"2019","unstructured":"Fauci AS, Redfield RR, Sigounas G,  Ending the HIV epidemic: a plan for the United States. JAMA 2019;321:844\u2013845."},{"key":"B11","series-title":"Cancer","first-page":"1290","article-title":"Annual Report to the Nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer","volume":"120","author":"Edwards BK","year":"2014","unstructured":"Edwards BK, Noone AM, Mariotto AB,  Annual Report to the Nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer. Cancer 2014;120:1290\u20131314."},{"key":"B12","series-title":"J Natl Compr Canc Netw","first-page":"23","article-title":"Understanding comorbidity profiles and their effect on treatment and survival in patients with colorectal cancer","volume":"16","author":"Hahn EE","year":"2018","unstructured":"Hahn EE, Gould MK, Munoz-Plaza CE,  Understanding comorbidity profiles and their effect on treatment and survival in patients with colorectal cancer. J Natl Compr Canc Netw 2018;16:23\u201334."},{"key":"B13","series-title":"Cancer","first-page":"249","article-title":"Prevalence of comorbidities and effect on survival in survivors of human papillomavirus-related and human papillomavirus-unrelated head and neck cancer in the United States","volume":"125","author":"Eytan DF","year":"2019","unstructured":"Eytan DF, Blackford AL, Eisele DW, Fakhry C. Prevalence of comorbidities and effect on survival in survivors of human papillomavirus-related and human papillomavirus-unrelated head and neck cancer in the United States. Cancer 2019;125:249\u2013260."},{"key":"B14","series-title":"Asian Pac J Cancer Prev","first-page":"7685","article-title":"Prevalence, awareness, control, and treatment of hypertension and diabetes in Korean cancer survivors: a cross-sectional analysis of the fourth and fifth Korea national health and nutrition examination surveys","volume":"14","author":"Choi KH","year":"2013","unstructured":"Choi KH, Park SM, Lee K,  Prevalence, awareness, control, and treatment of hypertension and diabetes in Korean cancer survivors: a cross-sectional analysis of the fourth and fifth Korea national health and nutrition examination surveys. Asian Pac J Cancer Prev 2013;14: 7685\u20137692."},{"key":"B15","series-title":"BMC Cancer","first-page":"613.","article-title":"Epidemiology and outcomes of previously undiagnosed diabetes in older women with breast cancer: an observational cohort study based on SEER-Medicare","volume":"12","author":"Griffiths RI","year":"2012","unstructured":"Griffiths RI, Danese MD, Gleeson ML, Valderas JM. Epidemiology and outcomes of previously undiagnosed diabetes in older women with breast cancer: an observational cohort study based on SEER-Medicare. BMC Cancer 2012;12:613."},{"key":"B16","series-title":"J Natl Cancer Inst","first-page":"365","article-title":"Long-term risk of cardiovascular disease in 10-year survivors of breast cancer","volume":"99","author":"Hooning MJ","year":"2007","unstructured":"Hooning MJ, Botma A, Aleman BM,  Long-term risk of cardiovascular disease in 10-year survivors of breast cancer. J Natl Cancer Inst 2007;99:365\u2013375."},{"key":"B17","series-title":"Oncology","first-page":"207","article-title":"Comorbidity in disease-free survivors of cervical cancer compared with the general female population","volume":"74","author":"Shin DW","year":"2008","unstructured":"Shin DW, Nam JH, Kwon YC,  Comorbidity in disease-free survivors of cervical cancer compared with the general female population. Oncology 2008;74:207\u2013215."},{"key":"B18","series-title":"BMC Cancer","first-page":"337.","article-title":"Cardiotoxicity of anthracycline agents for the treatment of cancer: systematic review and meta-analysis of randomised controlled trials","volume":"10","author":"Smith LA","year":"2010","unstructured":"Smith LA, Cornelius VR, Plummer CJ,  Cardiotoxicity of anthracycline agents for the treatment of cancer: systematic review and meta-analysis of randomised controlled trials. BMC Cancer 2010;10:337."},{"key":"B19","series-title":"J Cancer Surviv","first-page":"108","article-title":"Diabetes mellitus among cancer survivors","volume":"1","author":"Stava CJ","year":"2007","unstructured":"Stava CJ, Beck ML, Feng L,  Diabetes mellitus among cancer survivors. J Cancer Surviv 2007;1:108\u2013115."},{"key":"B20","series-title":"Ann Oncol","first-page":"1574","article-title":"Bevacizumab use and risk of cardiovascular adverse events among elderly patients with colorectal cancer receiving chemotherapy: a population-based study","volume":"24","author":"Tsai HT","year":"2013","unstructured":"Tsai HT, Marshall JL, Weiss SR,  Bevacizumab use and risk of cardiovascular adverse events among elderly patients with colorectal cancer receiving chemotherapy: a population-based study. Ann Oncol 2013;24:1574\u20131579."},{"key":"B21","series-title":"J Cancer Surviv","first-page":"253","article-title":"Cardiovascular risk factors among long-term survivors of breast, prostate, colorectal, and gynecologic cancers: a gap in survivorship care?","volume":"7","author":"Weaver KE","year":"2013","unstructured":"Weaver KE, Foraker RE, Alfano CM,  Cardiovascular risk factors among long-term survivors of breast, prostate, colorectal, and gynecologic cancers: a gap in survivorship care? J Cancer Surviv 2013;7:253\u2013261."},{"key":"B22","series-title":"CA Cancer J Clin","first-page":"363","article-title":"Cancer treatment and survivorship statistics, 2019","volume":"69","author":"Miller KD","year":"2019","unstructured":"Miller KD, Nogueira L, Mariotto AB,  Cancer treatment and survivorship statistics, 2019. CA Cancer J Clin 2019;69:363\u2013385."},{"key":"B23","series-title":"Ann Intern Med","first-page":"335","article-title":"Cigarette smoking prevalence among adults with HIV compared with the general adult population in the United States: cross-sectional surveys","volume":"162","author":"Mdodo R","year":"2015","unstructured":"Mdodo R, Frazier EL, Dube SR,  Cigarette smoking prevalence among adults with HIV compared with the general adult population in the United States: cross-sectional surveys. Ann Intern Med 2015;162:335\u2013344."},{"key":"B24","series-title":"Addict Behav","first-page":"39","article-title":"Patterns of drug use and HIV infection among adults in a nationally representative sample","volume":"68","author":"Shiau S","year":"2017","unstructured":"Shiau S, Arpadi SM, Yin MT, Martins SS. Patterns of drug use and HIV infection among adults in a nationally representative sample. Addict Behav 2017;68:39\u201344."},{"key":"B25","series-title":"Int J Epidemiol","first-page":"948","article-title":"Cohort profile: the Centers for AIDS Research Network of Integrated Clinical Systems","volume":"37","author":"Kitahata MM","year":"2008","unstructured":"Kitahata MM, Rodriguez B, Haubrich R,  Cohort profile: the Centers for AIDS Research Network of Integrated Clinical Systems. Int J Epidemiol 2008;37:948\u2013955."},{"key":"B26","series-title":"Am J Epidemiol","first-page":"996","article-title":"Lessons learned from the design and implementation of myocardial infarction adjudication tailored for HIV clinical cohorts","volume":"179","author":"Crane HM","year":"2014","unstructured":"Crane HM, Heckbert SR, Drozd DR,  Lessons learned from the design and implementation of myocardial infarction adjudication tailored for HIV clinical cohorts. Am J Epidemiol 2014;179:996\u20131005."},{"key":"B27","series-title":"J Acquir Immune Defic Syndr","first-page":"207","article-title":"Venous thromboembolism among people with HIV: design, implementation, and findings of a centralized adjudication system in clinical care sites across the United States","volume":"95","author":"Crane HM","year":"2024","unstructured":"Crane HM, Nance RM, Ruderman SA,  Venous thromboembolism among people with HIV: design, implementation, and findings of a centralized adjudication system in clinical care sites across the United States. J Acquir Immune Defic Syndr 2024;95:207\u2013214."},{"key":"B28","series-title":"N Engl J Med","first-page":"1572","article-title":"Chronic health conditions in adult survivors of childhood cancer","volume":"355","author":"Oeffinger KC","year":"2006","unstructured":"Oeffinger KC, Mertens AC, Sklar CA,  Chronic health conditions in adult survivors of childhood cancer. N Engl J Med 2006;355:1572\u20131582."},{"key":"B29","series-title":"Blood","first-page":"3129","article-title":"Prevalence and predictors of chronic health conditions after hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study","volume":"116","author":"Sun CL","year":"2010","unstructured":"Sun CL, Francisco L, Kawashima T,  Prevalence and predictors of chronic health conditions after hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study. Blood 2010;116:3129\u20133139."},{"key":"B30","article-title":"A package for survival analysis in R","author":"Therneau T","unstructured":"Therneau T, Lumley T, Atkinson E,  A package for survival analysis in R. Accessed February 28, 2025. Available at: https:\/\/CRAN.R-project.org\/package=survival"},{"key":"B31","series-title":"Modeling Survival Data: Extending the Cox Model.","author":"Therneau TM","year":"2013","unstructured":"Therneau TM, Grambsch PM. Modeling Survival Data: Extending the Cox Model. Springer; 2013."},{"key":"B32","series-title":"Am J Cancer Res","first-page":"880","article-title":"Prevalence of multimorbidity in survivors of 28 cancer sites: an English nationwide cross-sectional study","volume":"14","author":"Ahmad TA","year":"2024","unstructured":"Ahmad TA, Dayem Ullah AZ, Chelala C,  Prevalence of multimorbidity in survivors of 28 cancer sites: an English nationwide cross-sectional study. Am J Cancer Res 2024;14:880\u2013896."},{"key":"B33","series-title":"Clin Infect Dis","first-page":"1809","article-title":"Human immunodeficiency virus infection and diverse physical health outcomes: an umbrella review of meta-analyses of observational studies","volume":"70","author":"Grabovac I","year":"2020","unstructured":"Grabovac I, Veronese N, Stefanac S,  Human immunodeficiency virus infection and diverse physical health outcomes: an umbrella review of meta-analyses of observational studies. Clin Infect Dis 2020;70:1809\u20131815."},{"key":"B34","series-title":"JAMA Netw Open","first-page":"e2327584.","article-title":"Aging-related comorbidity burden among women and men with or at-risk for HIV in the US, 2008-2019","volume":"6","author":"Collins LF","year":"2023","unstructured":"Collins LF, Palella FJ, Mehta CC,  Aging-related comorbidity burden among women and men with or at-risk for HIV in the US, 2008-2019. JAMA Netw Open 2023;6:e2327584."},{"key":"B35","series-title":"HIV Med","first-page":"331","article-title":"Comorbidities in women living with HIV: a systematic review","volume":"23","author":"Raffe S","year":"2022","unstructured":"Raffe S, Sabin C, Gilleece Y. Comorbidities in women living with HIV: a systematic review. HIV Med 2022;23:331\u2013361."},{"key":"B36","series-title":"Nat Rev Dis Primers","first-page":"48.","article-title":"Multimorbidity","volume":"8","author":"Skou ST","year":"2022","unstructured":"Skou ST, Mair FS, Fortin M,  Multimorbidity. Nat Rev Dis Primers 2022;8:48."},{"key":"B37","series-title":"PLoS Med","first-page":"e1004325.","article-title":"The forecasted prevalence of comorbidities and multimorbidity in people with HIV in the United States through the year 2030: a modeling study","volume":"21","author":"Althoff KN","year":"2024","unstructured":"Althoff KN, Stewart C, Humes E,  The forecasted prevalence of comorbidities and multimorbidity in people with HIV in the United States through the year 2030: a modeling study. PLoS Med 2024;21: e1004325."},{"key":"B38","series-title":"Diabetes Care","first-page":"e105","article-title":"Incidence of new-onset type 2 diabetes after cancer: a Danish cohort study","volume":"45","author":"Sylow L","year":"2022","unstructured":"Sylow L, Grand MK, von Heymann A,  Incidence of new-onset type 2 diabetes after cancer: a Danish cohort study. Diabetes Care 2022;45:e105\u2013106."},{"key":"B39","series-title":"J Clin Oncol","first-page":"3257","article-title":"Risk of diabetes mellitus in long-term survivors of Hodgkin lymphoma","volume":"32","author":"van Nimwegen FA","year":"2014","unstructured":"van Nimwegen FA, Schaapveld M, Janus CP,  Risk of diabetes mellitus in long-term survivors of Hodgkin lymphoma. J Clin Oncol 2014;32:3257\u20133263."},{"key":"B40","series-title":"ESMO Open","first-page":"100218.","article-title":"Increased risk of diabetes in cancer survivors: a pooled analysis of 13 population-based cohort studies","volume":"6","author":"Xiao Y","year":"2021","unstructured":"Xiao Y, Wang H, Tang Y,  Increased risk of diabetes in cancer survivors: a pooled analysis of 13 population-based cohort studies. ESMO Open 2021;6:100218."},{"key":"B41","series-title":"Front Endocrinol (Lausanne)","first-page":"800995.","article-title":"The relationship between diabetes mellitus and cancers and its underlying mechanisms","volume":"13","author":"Zhu B","year":"2022","unstructured":"Zhu B, Qu S. The relationship between diabetes mellitus and cancers and its underlying mechanisms. Front Endocrinol (Lausanne) 2022;13:800995."},{"key":"B42","series-title":"Gut","first-page":"533","article-title":"Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study","volume":"54","author":"Davila JA","year":"2005","unstructured":"Davila JA, Morgan RO, Shaib Y,  Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study. Gut 2005;54:533\u2013539."},{"key":"B43","series-title":"Curr Opin Infect Dis","first-page":"10","article-title":"Weight gain and integrase inhibitors","volume":"33","author":"Eckard AR","year":"2020","unstructured":"Eckard AR, McComsey GA. Weight gain and integrase inhibitors. Curr Opin Infect Dis 2020;33:10\u201319."},{"key":"B44","series-title":"Medicine (Baltimore)","first-page":"e12268.","article-title":"Risk of diabetes mellitus in HIV-infected patients receiving highly active antiretroviral therapy: a nationwide population-based study","volume":"97","author":"Lin SP","year":"2018","unstructured":"Lin SP, Wu CY, Wang CB,  Risk of diabetes mellitus in HIV-infected patients receiving highly active antiretroviral therapy: a nationwide population-based study. Medicine (Baltimore) 2018;97:e12268."},{"key":"B45","series-title":"Arch Intern Med","first-page":"1179","article-title":"Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS cohort study","volume":"165","author":"Brown TT","year":"2005","unstructured":"Brown TT, Cole SR, Li X,  Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS cohort study. Arch Intern Med 2005;165:1179\u20131184."},{"key":"B46","series-title":"J Natl Cancer Inst","first-page":"206","article-title":"Myocardial infarction mortality risk after treatment for Hodgkin disease: a collaborative British cohort study","volume":"99","author":"Swerdlow AJ","year":"2007","unstructured":"Swerdlow AJ, Higgins CD, Smith P,  Myocardial infarction mortality risk after treatment for Hodgkin disease: a collaborative British cohort study. J Natl Cancer Inst 2007;99:206\u2013214."},{"key":"B47","series-title":"JAMA Intern Med","first-page":"1007","article-title":"Cardiovascular disease after Hodgkin lymphoma treatment: 40-year disease risk","volume":"175","author":"van Nimwegen FA","year":"2015","unstructured":"van Nimwegen FA, Schaapveld M, Janus CP,  Cardiovascular disease after Hodgkin lymphoma treatment: 40-year disease risk. JAMA Intern Med 2015;175:1007\u20131017."},{"key":"B48","series-title":"J Am Coll Cardiol","first-page":"926","article-title":"Risk of arterial thromboembolism in patients with cancer","volume":"70","author":"Navi BB","year":"2017","unstructured":"Navi BB, Reiner AS, Kamel H,  Risk of arterial thromboembolism in patients with cancer. J Am Coll Cardiol 2017;70:926\u2013938."},{"key":"B49","series-title":"BMJ Open","first-page":"e025874.","article-title":"Risk of myocardial infarction among people living with HIV: an updated systematic review and meta-analysis","volume":"9","author":"Eyawo O","year":"2019","unstructured":"Eyawo O, Brockman G, Goldsmith CH,  Risk of myocardial infarction among people living with HIV: an updated systematic review and meta-analysis. BMJ Open 2019;9:e025874."},{"key":"B50","series-title":"JAMA Intern Med","first-page":"614","article-title":"HIV infection and the risk of acute myocardial infarction","volume":"173","author":"Freiberg MS","year":"2013","unstructured":"Freiberg MS, Chang CC, Kuller LH,  HIV infection and the risk of acute myocardial infarction. JAMA Intern Med 2013;173:614\u2013622."},{"key":"B51","series-title":"Lancet","first-page":"1417","article-title":"Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration","volume":"371","author":"Sabin CA","year":"2008","unstructured":"Sabin CA, Worm SW, Weber R,  Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration. Lancet 2008;371:1417\u20131426."},{"key":"B52","series-title":"Br J Cancer","first-page":"1233","article-title":"Cardiovascular disease risk and androgen deprivation therapy in patients with localised prostate cancer: a prospective cohort study","volume":"117","author":"Haque R","year":"2017","unstructured":"Haque R, UlcickasYood M, Xu X,  Cardiovascular disease risk and androgen deprivation therapy in patients with localised prostate cancer: a prospective cohort study. Br J Cancer 2017;117:1233\u20131240."},{"key":"B53","series-title":"J Clin Pharmacol","first-page":"335","article-title":"Androgen deprivation therapy use increases the risk of heart failure in patients with prostate cancer: a population-based cohort study","volume":"59","author":"Kao HH","year":"2019","unstructured":"Kao HH, Kao LT, Li IH,  Androgen deprivation therapy use increases the risk of heart failure in patients with prostate cancer: a population-based cohort study. J Clin Pharmacol 2019;59:335\u2013343."},{"key":"B54","series-title":"J Acquir Immune Defic Syndr","first-page":"S10","article-title":"HIV, aging, and comorbidities research in clinical cohorts: 3 lessons learned using examples from the CNICS cohort","volume":"89","author":"Crane HM","year":"2022","unstructured":"Crane HM, Drumright L. HIV, aging, and comorbidities research in clinical cohorts: 3 lessons learned using examples from the CNICS cohort. J Acquir Immune Defic Syndr 2022;89(Suppl 1):S10\u201314."},{"key":"B55","series-title":"Front Immunol","first-page":"1965","article-title":"Systemic inflammation and the increased risk of inflamm-aging and age-associated diseases in people living with HIV on long term suppressive antiretroviral therapy","volume":"10","author":"Babu H","year":"2019","unstructured":"Babu H, Ambikan AT, Gabriel EE,  Systemic inflammation and the increased risk of inflamm-aging and age-associated diseases in people living with HIV on long term suppressive antiretroviral therapy. Front Immunol 2019;10:1965."},{"key":"B56","series-title":"Cancers (Basel)","first-page":"546","article-title":"Cancer and HIV: the molecular mechanisms of the deadly duo","volume":"16","author":"Omar A","year":"2024","unstructured":"Omar A, Marques N, Crawford N. Cancer and HIV: the molecular mechanisms of the deadly duo. Cancers (Basel) 2024;16:546."}],"container-title":["Journal of the National Comprehensive Cancer Network"],"original-title":[],"link":[{"URL":"https:\/\/jnccn.org\/view\/journals\/jnccn\/23\/7\/article-e257018.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jnccn.org\/downloadpdf\/journals\/jnccn\/23\/7\/article-e257018.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jnccn.org\/downloadpdf\/journals\/jnccn\/23\/7\/article-e257018.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T12:30:20Z","timestamp":1752150620000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnccn.org\/view\/journals\/jnccn\/23\/7\/article-e257018.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":56,"journal-issue":{"issue":"7"},"URL":"https:\/\/doi.org\/10.6004\/jnccn.2025.7018","relation":{},"ISSN":["1540-1405","1540-1413"],"issn-type":[{"value":"1540-1405","type":"print"},{"value":"1540-1413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}