{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:56:10Z","timestamp":1788386170845,"version":"build-2803163510"},"reference-count":55,"publisher":"Harborside Press, LLC","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>Patients with familial adenomatous polyposis (FAP) are at increased risk of developing cancer, with the most common sites being colorectal, duodenal\/ampullary and thyroid. In the last decade, an alarming increase in gastric cancer has been reported in the Western FAP population. These cancers are often diagnosed at an advanced stage with poor prognosis, even in patients undergoing regular upper endoscopic surveillance. Most gastric cancers in Western patients with FAP occur in the proximal stomach, where a carpeting of fundic gland polyposis hampers visualization of gastric cancer and its precursor lesions during endoscopic surveillance. Although fundic gland polyps are the most prevalent proximal polyp, several different dysplastic lesions can be found in the stomachs of patients with FAP. including fundic gland polyps with dysplasia, foveolar-type adenomas, pyloric gland adenomas, and intestinal-type adenomas. Although adenomas are the most likely precursors to gastric cancer, the exact lesions responsible for gastric cancer in FAP are not yet fully understood. This review focuses on gastric polyposis and the characteristics of gastric cancer in Western patients with FAP, including risk factors, lesion detection, surveillance and management of gastric polyposis, and areas for future research.<\/jats:p>","DOI":"10.6004\/jnccn.2025.7027","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T12:39:08Z","timestamp":1749645548000},"source":"Crossref","is-referenced-by-count":9,"title":["Gastric Polyposis and Cancer in Western Patients With Familial Adenomatous Polyposis: Epidemiology, Detection, and Management"],"prefix":"10.6004","volume":"23","author":[{"given":"Arthur S.","family":"Aelvoet","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands"},{"name":"Cancer Center Amsterdam, Amsterdam, the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien","family":"Dekker","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands"},{"name":"Cancer Center Amsterdam, Amsterdam, the Netherlands"},{"name":"Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Cruise","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH"},{"name":"Sanford R. Weiss, MD Center for Hereditary Colorectal Neoplasia, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Grady","sequence":"additional","affiliation":[{"name":"Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA"},{"name":"Division of Gastroenterology, University of Washington School of Medicine, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory E.","family":"Idos","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, City of Hope National Medical Center, Duarte, CA"},{"name":"Division of Clinical Cancer Genomics, City of Hope National Medical Center, Duarte, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Wisconsin-Madison, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AnnMarie","family":"Kieber-Emmons","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Duke University, Durham, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia S.","family":"Kupfer","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Chicago, Chicago, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold J.","family":"Markowitz","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology and Nutrition Service, Memorial Sloan Kettering Cancer Center, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Jewel","family":"Samadder","sequence":"additional","affiliation":[{"name":"Mayo Clinic Comprehensive Cancer Center, Phoenix, AZ"},{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, WI"},{"name":"University of Wisconsin Carbone Cancer Center, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew B.","family":"Yurgelun","sequence":"additional","affiliation":[{"name":"Dana-Farber Cancer Institute, Brigham & Women\u2019s Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol A.","family":"Burke","sequence":"additional","affiliation":[{"name":"Sanford R. 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Global burden of gastric cancer: epidemiological trends, risk factors, screening and prevention. Nat Rev Clin Oncol 2023;20:338\u2013349."},{"key":"B3","series-title":"Int J Epidemiol","first-page":"966","article-title":"Incidence of gastric cancer in the USA during 1999 to 2013: a 50-state analysis","volume":"47","author":"Wang Z","year":"2018","unstructured":"Wang Z, Graham DY, Khan A,  Incidence of gastric cancer in the USA during 1999 to 2013: a 50-state analysis. Int J Epidemiol 2018;47:966\u2013975."},{"key":"B4","series-title":"JAMA","first-page":"1723","article-title":"Age-specific trends in incidence of noncardia gastric cancer in US adults","volume":"303","author":"Anderson WF","year":"2010","unstructured":"Anderson WF, Camargo MC, Fraumeni JF,  Age-specific trends in incidence of noncardia gastric cancer in US adults. JAMA 2010;303:1723\u20131728."},{"key":"B5","series-title":"Dig Dis Sci","first-page":"2403","article-title":"Prevalence of Helicobacter pylori positive non-cardia gastric adenocarcinoma is low and decreasing in a US population","volume":"65","author":"Nguyen TH","year":"2020","unstructured":"Nguyen TH, Mallepally N, Hammad T,  Prevalence of Helicobacter pylori positive non-cardia gastric adenocarcinoma is low and decreasing in a US population. Dig Dis Sci 2020;65:2403\u20132411."},{"key":"B6","series-title":"EClinicalMedicine","first-page":"101404.","article-title":"The current and future incidence and mortality of gastric cancer in 185 countries, 2020-40: a population-based modelling study","volume":"47","author":"Morgan E","year":"2022","unstructured":"Morgan E, Arnold M, Camargo MC,  The current and future incidence and mortality of gastric cancer in 185 countries, 2020-40: a population-based modelling study. EClinicalMedicine 2022;47:101404."},{"key":"B7","series-title":"Gut","first-page":"823","article-title":"Is gastric cancer becoming a rare disease? A global assessment of predicted incidence trends to 2035","volume":"69","author":"Arnold M","year":"2020","unstructured":"Arnold M, Park JY, Camargo MC,  Is gastric cancer becoming a rare disease? A global assessment of predicted incidence trends to 2035. Gut 2020;69:823\u2013829."},{"key":"B8","series-title":"Gastrointest Endosc Clin N Am","first-page":"147","article-title":"Genetic syndromes associated with gastric cancer","volume":"32","author":"Kim W","year":"2022","unstructured":"Kim W, Kidambi T, Lin J, Idos G. Genetic syndromes associated with gastric cancer. Gastrointest Endosc Clin N Am 2022;32:147\u2013162."},{"key":"B9","series-title":"Ann Surg","first-page":"101","article-title":"The impact of familial adenomatous polyposis on the tumorigenesis and mortality at the several organs. 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J Gastrointest Surg 2024;28:1890\u20131896."},{"key":"B14","series-title":"J Gastrointest Oncol","first-page":"734","article-title":"Upper gastrointestinal neoplasia in familial adenomatous polyposis: prevalence, endoscopic features and management","volume":"10","author":"Campos FG","year":"2019","unstructured":"Campos FG, Martinez CAR, Sulbaran M,  Upper gastrointestinal neoplasia in familial adenomatous polyposis: prevalence, endoscopic features and management. J Gastrointest Oncol 2019;10:734\u2013744."},{"key":"B15","series-title":"Fam Cancer","first-page":"363","article-title":"Gastric tumours in FAP","volume":"16","author":"Walton SJ","year":"2017","unstructured":"Walton SJ, Frayling IM, Clark SK, Latchford A. Gastric tumours in FAP. 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