{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:41:40Z","timestamp":1792100500140,"version":"4.4.0"},"reference-count":74,"publisher":"Harborside Press, LLC","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4]]},"abstract":"\n Background:<\/jats:bold>\n ASCO recommends extended venous thromboembolism (VTE) prophylaxis with low-molecular-weight heparin (LMWH) or direct oral anticoagulants (DOACs) following cancer surgery. However, these recommendations were based on trials using routine venography, which detects asymptomatic VTEs, and real-life efficacy is not well studied. We aimed to assess the association of extended VTE prophylaxis with the incidence of clinically significant VTE after elective cancer surgery.\n Patients and Methods:<\/jats:bold>\n In this retrospective, population-based cohort study, we identified patients who underwent surgical resection for lung, breast, esophageal, gastric, pancreas, and colon cancer from 2010 to 2017 using the SEER\u2013Medicare linked dataset. Patients were divided into 1 of 2 main groups for comparative analyses: those who received extended VTE prophylaxis after cancer surgery and those who did not. Patients who received extended VTE prophylaxis after cancer surgery were identified as those prescribed prophylactic doses of LMWH or a DOAC within 7 days of discharge, as captured in Medicare Part D files.\n Results:<\/jats:bold>\n A total of 113,739 Medicare beneficiaries were identified, of whom 1,570 (1.4%) received extended VTE prophylaxis. There was a year-over-year increase in the use of extended VTE prophylaxis during the study period, rising from 0.6% in 2010 to 3.3% in 2017. The overall incidence of VTE was 1.6% at 1 month, 4.3% at 6 months, 5.7% at 12 months, with significant differences observed across cancer types (\n P<\/jats:italic>\n <.001). However, patients who received extended VTE prophylaxis had a higher 1-year cumulative incidence of postoperative VTE compared with those who did not (11.4% vs 5.3%;\n P<\/jats:italic>\n <.001), an association that was consistent across cancer sites. In adjusted analyses, extended VTE prophylaxis was independently associated with an increased risk of VTE (hazard ratio, 1.6; 95% CI, 1.3\u20132.0;\n P<\/jats:italic>\n <.001). Extended prophylaxis was also associated with a higher 1-year incidence of bleeding events compared with patients who did not receive prophylaxis (12.0% vs 8.5%;\n P<\/jats:italic>\n <.001).\n Conclusions:<\/jats:bold>\n The utilization of extended VTE prophylaxis after cancer surgery remains low, although it has increased every year. Paradoxically, patients who received extended VTE prophylaxis had higher incidences of clinically significant VTE and bleeding compared with those who did not, likely reflecting patient selection and surveillance bias after surgery. In light of these findings, national guidelines recommending postoperative extended VTE prophylaxis, and its use as a surrogate for quality of care, should continue to be re-examined.\n <\/jats:p>","DOI":"10.6004\/jnccn.2025.7128","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:28:37Z","timestamp":1773937717000},"source":"Crossref","is-referenced-by-count":1,"title":["The Association of Extended Venous Thromboembolism Prophylaxis and Venous Thromboembolism After Cancer Surgery"],"prefix":"10.6004","volume":"24","author":[{"given":"Zhi Ven","family":"Fong","sequence":"first","affiliation":[{"name":"Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po Hong","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith D.","family":"Lillemoe","sequence":"additional","affiliation":[{"name":"Department of Surgery, Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee-Chee","family":"Stucky","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin T.","family":"Brady","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Pockaj","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Cronin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George C.","family":"Linderman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Potter","sequence":"additional","affiliation":[{"name":"Department of Surgery, Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Fu Jeffrey","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michail N.","family":"Mavros","sequence":"additional","affiliation":[{"name":"Department of Surgery, Johns Hopkins University, Baltimore, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Fagenholz","sequence":"additional","affiliation":[{"name":"Department of Surgery, Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William V.","family":"Kastrinakis","sequence":"additional","affiliation":[{"name":"Department of Surgery, Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Poruk","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mayo Clinic Jacksonville, Jacksonville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius A.","family":"Thiels","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth B.","family":"Habermann","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil","family":"Wasif","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hui","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motaz","family":"Qadan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4047","reference":[{"key":"B1","series-title":"N Engl J Med","first-page":"1601","article-title":"A prospective study of venous thromboembolism after major trauma","volume":"331","author":"Geerts WH","year":"1994","unstructured":"Geerts WH, Code KI, Jay RM, A prospective study of venous thromboembolism after major trauma. 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JAMA 2013;310:1482\u20131489."},{"key":"B21","series-title":"J Clin Epidemiol","first-page":"1245","article-title":"Validation of a combined comorbidity index","volume":"47","author":"Charlson M","year":"1994","unstructured":"Charlson M, Szatrowski TP, Peterson J, Validation of a combined comorbidity index. J Clin Epidemiol 1994;47:1245\u20131251."},{"key":"B22","series-title":"Med Care","first-page":"IV","article-title":"Utility of the SEER-Medicare data to identify chemotherapy use","volume":"40(Suppl 8)","author":"Warren JL","year":"2002","unstructured":"Warren JL, Harlan LC, Fahey A, Utility of the SEER-Medicare data to identify chemotherapy use. Med Care 2002;40(Suppl 8):IV\u201355\u201361."},{"key":"B23","series-title":"Ann Intern Med","first-page":"268","article-title":"Sensitivity analysis in observational research: introducing the E-value","volume":"167","author":"VanderWeele TJ","year":"2017","unstructured":"VanderWeele TJ, Ding P. Sensitivity analysis in observational research: introducing the E-value. Ann Intern Med 2017;167:268\u2013274."},{"key":"B24","series-title":"Ann Surg Oncol","first-page":"3214","article-title":"Venous thromboembolic events following major pelvic and abdominal surgeries for cancer: a prospective cohort study","volume":"25","author":"Serrano PE","year":"2018","unstructured":"Serrano PE, Parpia S, Linkins LA, Venous thromboembolic events following major pelvic and abdominal surgeries for cancer: a prospective cohort study. Ann Surg Oncol 2018;25:3214\u20133221."},{"key":"B25","series-title":"Ann Surg Oncol","first-page":"5522","article-title":"Adherence to extended venous thromboembolism prophylaxis and outcomes after complex gastrointestinal oncologic surgery","volume":"30","author":"Mavros MN","year":"2023","unstructured":"Mavros MN, Johnson LA, Schootman M, Adherence to extended venous thromboembolism prophylaxis and outcomes after complex gastrointestinal oncologic surgery. Ann Surg Oncol 2023;30:5522\u20135531."},{"key":"B26","series-title":"J Trauma","first-page":"1132","article-title":"Can increased incidence of deep vein thrombosis (DVT) be used as a marker of quality of care in the absence of standardized screening? The potential effect of surveillance bias on reported DVT rates after trauma","volume":"63","author":"Haut ER","year":"2007","unstructured":"Haut ER, Noll K, Efron DT, Can increased incidence of deep vein thrombosis (DVT) be used as a marker of quality of care in the absence of standardized screening? The potential effect of surveillance bias on reported DVT rates after trauma. J Trauma 2007;63:1132\u20131135, discussion 1135\u20131137."},{"key":"B27","series-title":"Obstet Gynecol Surv","first-page":"440","article-title":"Effect of three decades of screening mammography on breast-cancer incidence","volume":"68","author":"Bleyer A","year":"2013","unstructured":"Bleyer A, Welch HG. Effect of three decades of screening mammography on breast-cancer incidence. Obstet Gynecol Surv 2013;68:440\u2013442."},{"key":"B28","series-title":"JAMA Otolaryngol Head Neck Surg","first-page":"317","article-title":"Current thyroid cancer trends in the United States","volume":"140","author":"Davies L","year":"2014","unstructured":"Davies L, Welch HG. Current thyroid cancer trends in the United States. JAMA Otolaryngol Head Neck Surg 2014;140:317\u2013322."},{"key":"B29","series-title":"J Natl Cancer Inst","first-page":"1325","article-title":"Prostate cancer diagnosis and treatment after the introduction of prostate-specific antigen screening: 1986\u20132005","volume":"101","author":"Welch HG","year":"2009","unstructured":"Welch HG, Albertsen PC. Prostate cancer diagnosis and treatment after the introduction of prostate-specific antigen screening: 1986\u20132005. J Natl Cancer Inst 2009;101:1325\u20131329."},{"key":"B30","series-title":"J Am Coll Surg","first-page":"871","article-title":"Use of helical CT is associated with an increased incidence of postoperative pulmonary emboli in cancer patients with no change in the number of fatal pulmonary emboli","volume":"208","author":"Auer RC","year":"2009","unstructured":"Auer RC, Schulman AR, Tuorto S, Use of helical CT is associated with an increased incidence of postoperative pulmonary emboli in cancer patients with no change in the number of fatal pulmonary emboli. J Am Coll Surg 2009;208:871\u2013878, discussion 878\u2013880."},{"key":"B31","series-title":"Radiology","first-page":"563","article-title":"Pulmonary embolism at multi- detector row CT of chest: one-year survival of treated and untreated patients","volume":"239","author":"Engelke C","year":"2006","unstructured":"Engelke C, Rummeny EJ, Marten K. Pulmonary embolism at multi- detector row CT of chest: one-year survival of treated and untreated patients. Radiology 2006;239:563\u2013575."},{"key":"B32","series-title":"Am J Manag Care","first-page":"1082","article-title":"Economic evaluation of enoxaparin as prophylaxis against venous thromboembolism in seriously ill medical patients: a US perspective","volume":"8","author":"de Lissovoy G","year":"2002","unstructured":"de Lissovoy G, Subedi P. Economic evaluation of enoxaparin as prophylaxis against venous thromboembolism in seriously ill medical patients: a US perspective. Am J Manag Care 2002;8:1082\u20131088."},{"key":"B33","series-title":"J Surg Res","first-page":"77","article-title":"Perioperative pharmacologic prophylaxis of venous thromboembolism: a professional liability analysis","volume":"274","author":"Anteby R","year":"2022","unstructured":"Anteby R, Verdugo FL, Aaron DG, Perioperative pharmacologic prophylaxis of venous thromboembolism: a professional liability analysis. J Surg Res 2022;274:77\u201384."},{"key":"B34","series-title":"J Gastrointest Surg","first-page":"1986","article-title":"Patient adherence and experience with extended use of prophylactic low-molecular-weight heparin following pancreas and liver resection","volume":"20","author":"Lemke M","year":"2016","unstructured":"Lemke M, Beyfuss K, Hallet J, Patient adherence and experience with extended use of prophylactic low-molecular-weight heparin following pancreas and liver resection. J Gastrointest Surg 2016;20:1986\u20131996."},{"key":"B35","series-title":"Surg Endosc","first-page":"267","article-title":"Patient\u2019s compliance is a contributor to failure of extended antithrombotic prophylaxis in colorectal surgery: prospective cohort study","volume":"36","author":"Cordova-Cassia C","year":"2022","unstructured":"Cordova-Cassia C, Wong D, Cotter MB, Patient\u2019s compliance is a contributor to failure of extended antithrombotic prophylaxis in colorectal surgery: prospective cohort study. Surg Endosc 2022;36:267\u2013273."},{"key":"B36","series-title":"Int J Gynecol Cancer","first-page":"802","article-title":"Patients\u2019 experience and compliance with extended low molecular weight heparin prophylaxis post- surgery for gynecological cancer: a prospective observational study","volume":"29","author":"Marchocki Z","year":"2019","unstructured":"Marchocki Z, Norris L, O\u2019Toole S, Patients\u2019 experience and compliance with extended low molecular weight heparin prophylaxis post- surgery for gynecological cancer: a prospective observational study. Int J Gynecol Cancer 2019;29:802\u2013809."},{"key":"B37","series-title":"Gynecol Oncol","first-page":"18","article-title":"Patient cost associated with filling a prescription for extended-duration venous thromboembolism (VTE) prophylaxis following surgery for gynecologic cancer","volume":"127","author":"Cain K","year":"2012","unstructured":"Cain K, Schmeler KM, Langley G, Patient cost associated with filling a prescription for extended-duration venous thromboembolism (VTE) prophylaxis following surgery for gynecologic cancer. 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