{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:56:12Z","timestamp":1791896172500,"version":"4.3.4"},"reference-count":45,"publisher":"Harborside Press, LLC","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Treatment for B-cell acute lymphoblastic leukemia (B-ALL) lasts &gt;2 years and can impact families. The Children\u2019s Oncology Group multicenter therapeutic trial AALL0932 randomized patients with NCI standard-risk, average-risk B-ALL (NCI-SR AR B-ALL) to receive maintenance vincristine\/dexamethasone every 4 or 12 weeks (VCR\/DEX4 or VCR\/DEX12, respectively). Embedded in AALL0932, this study aimed to (1) longitudinally measure adverse family outcomes overall, and (2) determine whether patients on the VCR\/DEX4 regimen (vs VCR\/DEX12) had fewer adverse family outcomes.\n                    <jats:bold>Methods:<\/jats:bold>\n                    Patients with NCI-SR AR B-ALL who were offered enrollment on the multicenter randomized-controlled therapeutic trial AALL0932 were aged \u22654 years with an English-speaking parent. Parent-reported surveys were administered at T1\u2013T5 (approximately 2, 9, 18, 26, and 38 months after diagnosis, respectively; T5 was assessed only in boys) and assessed household changes since leukemia diagnosis, leukemia-related household expenses in the past 4 weeks, unhealthy family functioning (Family Assessment Device score &gt;2), and parents\u2019 perceived child vulnerability (Child Vulnerability Scale \u226510). Postrandomization outcomes at T3 and T4 were compared between treatment groups using generalized linear mixed models and multivariable logistic regression models, as appropriate, adjusting for race and ethnicity.\n                    <jats:bold>Results:<\/jats:bold>\n                    Among 555 participants with completed evaluations, 420 were randomized (mean [SD] age, 6.0 [1.6] years; 45.7% female). At T1, 56.2% of randomized participants reported household changes since diagnosis (81.2% by T4), 88.6% reported \u2265$100 in leukemia-related household expenses in the past 4 weeks (61.5% at T4), 19.0% had unhealthy family functioning (23.9% at T4), and 55.8% perceived their child as vulnerable (62.5% at T4). In multivariable models, VCR\/DEX4 (vs VCR\/DEX12) had an increased likelihood of reporting \u2265$100 in leukemia-related expenses in the past 4 weeks (odds ratio, 1.73; 95% CI, 1.03\u20132.91), but other outcomes were similar between treatment arms.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    B-ALL family burdens develop early. Reducing maintenance VCR\/DEX frequency may decrease expenses but not other outcomes. Interventions are needed to support families early and throughout ALL therapy.\n                  <\/jats:p>","DOI":"10.6004\/jnccn.2026.7048","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:40:39Z","timestamp":1791895239000},"source":"Crossref","is-referenced-by-count":0,"title":["Adverse Family Outcomes in Children With B-Cell Acute Lymphoblastic Leukemia From the Multicenter Trial Children\u2019s Oncology Group AALL0932"],"prefix":"10.6004","volume":"24","author":[{"given":"Rozalyn L.","family":"Rodwin","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Yale University School of Medicine, New Haven, CT"},{"name":"Yale Cancer Center, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Kairalla","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Colleges of Medicine and Public Health & Health Professions, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Hibbitts","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Colleges of Medicine and Public Health & Health Professions, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyn M.","family":"Balsamo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Yale University School of Medicine, New Haven, CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Devidas","sequence":"additional","affiliation":[{"name":"Department of Global Pediatric Medicine, St. Jude Children\u2019s Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenna","family":"Mossman","sequence":"additional","affiliation":[{"name":"Georgetown University Lombardi Comprehensive Cancer Center, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Dreyzin","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Branch, National Cancer Institute and Center for Cellular Engineering, Clinical Center, National Institutes of Health, Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi J.","family":"Winick","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian","family":"Sung","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Conley","sequence":"additional","affiliation":[{"name":"Georgetown University Lombardi Comprehensive Cancer Center, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Perlmutter Cancer Center, NYU Langone Health, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Hunger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Center for Childhood Cancer Research, Children\u2019s Hospital of Philadelphia, Philadelphia, PA"},{"name":"Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Raetz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Perlmutter Cancer Center, NYU Langone Health, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten K.","family":"Ness","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control, St. Jude Children\u2019s Research Hospital, Memphis, TN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mignon L.","family":"Loh","sequence":"additional","affiliation":[{"name":"Ben Towne Center for Childhood Cancer Research, Seattle Children\u2019s Research Institute, Seattle, WA"},{"name":"Department of Pediatrics, Seattle Children\u2019s Hospital, University of Washington, Seattle, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reuven J.","family":"Schore","sequence":"additional","affiliation":[{"name":"Division of Oncology, Center for Cancer and Blood Disorders, Children\u2019s National Hospital, Washington, DC"},{"name":"Department of Pediatrics and Clinical and Translational Oncology Program, George Washington University School of Medicine and Health Sciences, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne L.","family":"Angiolillo","sequence":"additional","affiliation":[{"name":"Servier Pharmaceuticals, Boston, MA"},{"name":"Formerly at Children\u2019s National Hospital, and George Washington University School of Medicine, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina S.","family":"Kadan-Lottick","sequence":"additional","affiliation":[{"name":"Georgetown University Lombardi Comprehensive Cancer Center, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4047","reference":[{"key":"B1","series-title":"J Clin Oncol","first-page":"602","article-title":"Outcome in children with standard-risk B-cell acute lymphoblastic leukemia: results of Children\u2019s Oncology Group trial AALL0331","volume":"38","author":"Maloney KW","year":"2020","unstructured":"Maloney KW, Devidas M, Wang C,  Outcome in children with standard-risk B-cell acute lymphoblastic leukemia: results of Children\u2019s Oncology Group trial AALL0331. J Clin Oncol 2020;38:602\u2013612."},{"key":"B2","series-title":"J Clin Oncol","first-page":"1437","article-title":"Excellent outcomes with reduced frequency of vincristine and dexamethasone pulses in standard-risk B-lymphoblastic leukemia: results from Children\u2019s Oncology Group AALL0932","volume":"39","author":"Angiolillo AL","year":"2021","unstructured":"Angiolillo AL, Schore RJ, Kairalla JA,  Excellent outcomes with reduced frequency of vincristine and dexamethasone pulses in standard-risk B-lymphoblastic leukemia: results from Children\u2019s Oncology Group AALL0932. J Clin Oncol 2021;39:1437\u20131447."},{"key":"B3","series-title":"J Natl Cancer Inst","first-page":"1167","article-title":"Persistence of chemotherapy-induced peripheral neuropathy despite vincristine reduction in childhood B-acute lymphoblastic leukemia","volume":"114","author":"Rodwin RL","year":"2022","unstructured":"Rodwin RL, Kairalla JA, Hibbitts E,  Persistence of chemotherapy-induced peripheral neuropathy despite vincristine reduction in childhood B-acute lymphoblastic leukemia. J Natl Cancer Inst 2022;114:1167\u20131175."},{"key":"B4","series-title":"J Peripher Nerv Syst","first-page":"37","article-title":"Patterns and severity of vincristine-induced peripheral neuropathy in children with acute lymphoblastic leukemia","volume":"20","author":"Lavoie Smith EM","year":"2015","unstructured":"Lavoie Smith EM, Li L, Chiang C,  Patterns and severity of vincristine-induced peripheral neuropathy in children with acute lymphoblastic leukemia. J Peripher Nerv Syst 2015;20:37\u201346."},{"key":"B5","series-title":"Support Care Cancer","first-page":"967","article-title":"Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia","volume":"13","author":"Hochhauser CJ","year":"2005","unstructured":"Hochhauser CJ, Lewis M, Kamen BA, Cole PD. Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia. Support Care Cancer 2005;13:967\u2013974."},{"key":"B6","series-title":"Support Care Cancer","first-page":"146","article-title":"\u2018Enough is enough\u2019: qualitative findings on the impact of dexamethasone during reinduction\/consolidation for paediatric acute lymphoblastic leukaemia","volume":"10","author":"McGrath P","year":"2002","unstructured":"McGrath P, Pitcher L. \u2018Enough is enough\u2019: qualitative findings on the impact of dexamethasone during reinduction\/consolidation for paediatric acute lymphoblastic leukaemia. Support Care Cancer 2002;10:146\u2013155."},{"key":"B7","series-title":"Pediatr Blood Cancer","first-page":"2277","article-title":"Family life events in the first year of acute lymphoblastic leukemia therapy: a Children\u2019s Oncology Group report","volume":"61","author":"Lau S","year":"2014","unstructured":"Lau S, Lu X, Balsamo L,  Family life events in the first year of acute lymphoblastic leukemia therapy: a Children\u2019s Oncology Group report. Pediatr Blood Cancer 2014;61:2277\u20132284."},{"key":"B8","series-title":"Child Care Health Dev","first-page":"155","article-title":"\u2018Building a new normality\u2019: mothers\u2019 experiences of caring for a child with acute lymphoblastic leukaemia","volume":"33","author":"Earle EA","year":"2007","unstructured":"Earle EA, Clarke SA, Eiser C, Sheppard L. \u2018Building a new normality\u2019: mothers\u2019 experiences of caring for a child with acute lymphoblastic leukaemia. Child Care Health Dev 2007;33:155\u2013160."},{"key":"B9","series-title":"Cancer","first-page":"571","article-title":"Longitudinal analysis of quality-of-life outcomes in children during treatment for acute lymphoblastic leukemia: a report from the Children\u2019s Oncology Group AALL0932 trial","volume":"124","author":"Zheng DJ","year":"2018","unstructured":"Zheng DJ, Lu X, Schore RJ,  Longitudinal analysis of quality-of-life outcomes in children during treatment for acute lymphoblastic leukemia: a report from the Children\u2019s Oncology Group AALL0932 trial. Cancer 2018;124:571\u2013579."},{"key":"B10","series-title":"Int J Cancer","first-page":"332","article-title":"Prospective, longitudinal assessment of quality of life in children from diagnosis to 3 months off treatment for standard risk acute lymphoblastic leukemia: results of Children\u2019s Oncology Group study AALL0331","volume":"138","author":"Mitchell HR","year":"2016","unstructured":"Mitchell HR, Lu X, Myers RM,  Prospective, longitudinal assessment of quality of life in children from diagnosis to 3 months off treatment for standard risk acute lymphoblastic leukemia: results of Children\u2019s Oncology Group study AALL0331. Int J Cancer 2016;138:332\u2013339."},{"key":"B11","series-title":"Pediatr Blood Cancer","first-page":"e70029","article-title":"Diminished quality of life despite reduced treatment in children with B-lymphoblastic leukemia: Children\u2019s Oncology Group AALL0932","volume":"73","author":"Balsamo LM","year":"2026","unstructured":"Balsamo LM, Kairalla JA, Hibbitts E,  Diminished quality of life despite reduced treatment in children with B-lymphoblastic leukemia: Children\u2019s Oncology Group AALL0932. Pediatr Blood Cancer 2026;73:e70029."},{"key":"B12","series-title":"J Clin Oncol","first-page":"2803","article-title":"Intensive oral methotrexate protects against lymphoid marrow relapse in childhood B-precursor acute lymphoblastic leukemia","volume":"14","author":"Winick N","year":"1996","unstructured":"Winick N, Shuster JJ, Bowman WP,  Intensive oral methotrexate protects against lymphoid marrow relapse in childhood B-precursor acute lymphoblastic leukemia. J Clin Oncol 1996;14:2803\u20132811."},{"key":"B13","article-title":"Survey: $100 a month remains the maximum health insurance premium most Americans can afford","author":"Coleman K","unstructured":"Coleman K. Survey: $100 a month remains the maximum health insurance premium most Americans can afford. Accessed June 2, 2026. Available at: https:\/\/web.archive.org\/web\/20210924112926\/http:\/www.healthpocket.com\/healthcare-research\/surveys\/survey-health-insurance-affordability-2018"},{"key":"B14","series-title":"J Marital Family Therapy","first-page":"345","article-title":"The McMaster family assessment device: reliability and validity","volume":"11","author":"Miller IW","year":"1985","unstructured":"Miller IW, Epstein NB, Bishop DS, Keitner GI. The McMaster family assessment device: reliability and validity. J Marital Family Therapy 1985;11:345\u2013356."},{"key":"B15","article-title":"Evaluating and Treating Families: The McMaster Approach.","author":"Ryan C","year":"2012","unstructured":"Ryan C, Epstein NB, Keitner GI,  Evaluating and Treating Families: The McMaster Approach. Routledge; 2012."},{"key":"B16","series-title":"Fam Process","first-page":"97","article-title":"Ontario Child Health Study: reliability and validity of the general functioning subscale of the McMaster Family Assessment Device","volume":"27","author":"Byles J","year":"1988","unstructured":"Byles J, Byrne C, Boyle MH, Offord DR. Ontario Child Health Study: reliability and validity of the general functioning subscale of the McMaster Family Assessment Device. Fam Process 1988;27:97\u2013104."},{"key":"B17","series-title":"J Dev Behav Pediatr","first-page":"26","article-title":"Family functioning in the context of pediatric chronic conditions","volume":"31","author":"Herzer M","year":"2010","unstructured":"Herzer M, Godiwala N, Hommel KA,  Family functioning in the context of pediatric chronic conditions. J Dev Behav Pediatr 2010;31:26\u201334."},{"key":"B18","series-title":"J Pediatr Psychol","first-page":"89","article-title":"The Child Vulnerability Scale: an instrument to measure parental perceptions of child vulnerability","volume":"21","author":"Forsyth BW","year":"1996","unstructured":"Forsyth BW, Horwitz SM, Leventhal JM,  The Child Vulnerability Scale: an instrument to measure parental perceptions of child vulnerability. J Pediatr Psychol 1996;21:89\u2013101."},{"key":"B19","series-title":"Pediatr Blood Cancer","first-page":"105","article-title":"Trajectory of material hardship and income poverty in families of children undergoing chemotherapy: a prospective cohort study","volume":"63","author":"Bona K","year":"2016","unstructured":"Bona K, London WB, Guo D,  Trajectory of material hardship and income poverty in families of children undergoing chemotherapy: a prospective cohort study. Pediatr Blood Cancer 2016;63:105\u2013111."},{"key":"B20","series-title":"Front Oncol","first-page":"690454","article-title":"Racial and ethnic differences in the financial consequences of cancer-related employment disruption","volume":"11","author":"Biddell CB","year":"2021","unstructured":"Biddell CB, Wheeler SB, Angove RSM,  Racial and ethnic differences in the financial consequences of cancer-related employment disruption. Front Oncol 2021;11:690454."},{"key":"B21","series-title":"Int J Environ Res Public Health","first-page":"15887","article-title":"Characterizing cancer and work disparities using electronic health records","volume":"19","author":"Allen JL","year":"2022","unstructured":"Allen JL, Du R, Powell T,  Characterizing cancer and work disparities using electronic health records. Int J Environ Res Public Health 2022;19:15887."},{"key":"B22","series-title":"Pediatrics","first-page":"e1187","article-title":"Parental separation and pediatric cancer: a Danish cohort study","volume":"129","author":"Grant S","year":"2012","unstructured":"Grant S, Carlsen K, Bidstrup PE,  Parental separation and pediatric cancer: a Danish cohort study. Pediatrics 2012;129:e1187\u20131191."},{"key":"B23","series-title":"J Clin Oncol","first-page":"872","article-title":"Does childhood cancer affect parental divorce rates? A population-based study","volume":"28","author":"Syse A","year":"2010","unstructured":"Syse A, Loge JH, Lyngstad TH. Does childhood cancer affect parental divorce rates? A population-based study. J Clin Oncol 2010;28:872\u2013877."},{"key":"B24","series-title":"Eur J Oncol Nurs","first-page":"102514","article-title":"Impact of pediatric cancer on parents\u2019 relationships","volume":"69","author":"Gajda J","year":"2024","unstructured":"Gajda J, Johns C, Zimmermann T. Impact of pediatric cancer on parents\u2019 relationships. Eur J Oncol Nurs 2024;69:102514."},{"key":"B25","article-title":"Number, Timing, and Duration of Marriages and Divorces: 2016","author":"Mayol-Garc\u00eda Y","unstructured":"Mayol-Garc\u00eda Y, Gurrentz B, Kreider RM. Number, Timing, and Duration of Marriages and Divorces: 2016. Accessed June 2, 2026. Available at: https:\/\/www.census.gov\/content\/dam\/Census\/library\/publications\/2021\/demo\/p70-167.pdf"},{"key":"B26","series-title":"Pediatr Blood Cancer","first-page":"e28093","article-title":"Influence of pediatric cancer-related financial burden on parent distress and other stress-related symptoms","volume":"67","author":"Santacroce SJ","year":"2020","unstructured":"Santacroce SJ, Kneipp SM. Influence of pediatric cancer-related financial burden on parent distress and other stress-related symptoms. Pediatr Blood Cancer 2020;67:e28093."},{"key":"B27","series-title":"Support Care Cancer","first-page":"36","article-title":"Financial toxicity among pediatric oncology families during therapy and early survivorship: a qualitative analysis","volume":"33","author":"Ohlsen TJD","year":"2024","unstructured":"Ohlsen TJD, Hale MR, Larson AJ,  Financial toxicity among pediatric oncology families during therapy and early survivorship: a qualitative analysis. Support Care Cancer 2024;33:36."},{"key":"B28","series-title":"J Natl Cancer Inst","first-page":"1179","article-title":"Disparities in parental distress in a multicenter clinical trial for pediatric acute lymphoblastic leukemia","volume":"115","author":"Umaretiya PJ","year":"2023","unstructured":"Umaretiya PJ, Koch VB, Flamand Y,  Disparities in parental distress in a multicenter clinical trial for pediatric acute lymphoblastic leukemia. J Natl Cancer Inst 2023;115:1179\u20131187."},{"key":"B29","series-title":"Child Obes","first-page":"125","article-title":"Sleep, food insecurity, and weight status: findings from the Family Life, Activity, Sun, Health, and Eating Study","volume":"17","author":"Do EK","year":"2021","unstructured":"Do EK, Bowen GA, Ksinan AJ,  Sleep, food insecurity, and weight status: findings from the Family Life, Activity, Sun, Health, and Eating Study. Child Obes 2021;17:125\u2013135."},{"key":"B30","series-title":"Lancet Child Adolesc Health","first-page":"465","article-title":"Nutrition during childhood cancer treatment: current understanding and a path for future research","volume":"4","author":"Joffe L","year":"2020","unstructured":"Joffe L, Ladas EJ. Nutrition during childhood cancer treatment: current understanding and a path for future research. Lancet Child Adolesc Health 2020;4:465\u2013475."},{"key":"B31","series-title":"Leuk Lymphoma","first-page":"138","article-title":"Limitations of body mass index to assess body composition due to sarcopenic obesity during leukemia therapy","volume":"59","author":"Orgel E","year":"2018","unstructured":"Orgel E, Mueske NM, Sposto R,  Limitations of body mass index to assess body composition due to sarcopenic obesity during leukemia therapy. Leuk Lymphoma 2018;59:138\u2013145."},{"key":"B32","series-title":"Leuk Lymphoma","first-page":"1140","article-title":"Association between body mass index at diagnosis and pediatric leukemia mortality and relapse: a systematic review and meta-analysis","volume":"57","author":"Amankwah EK","year":"2016","unstructured":"Amankwah EK, Saenz AM, Hale GA, Brown PA. Association between body mass index at diagnosis and pediatric leukemia mortality and relapse: a systematic review and meta-analysis. Leuk Lymphoma 2016;57:1140\u20131148."},{"key":"B33","series-title":"Support Care Cancer","first-page":"3043","article-title":"Malnutrition is associated with worse health-related quality of life in children with cancer","volume":"23","author":"Brinksma A","year":"2015","unstructured":"Brinksma A, Sanderman R, Roodbol PF,  Malnutrition is associated with worse health-related quality of life in children with cancer. Support Care Cancer 2015;23:3043\u20133052."},{"key":"B34","series-title":"J Natl Cancer Inst","first-page":"1593","article-title":"Addressing transportation insecurity among patients with cancer","volume":"114","author":"Graboyes EM","year":"2022","unstructured":"Graboyes EM, Chaiyachati KH, Sisto Gall J,  Addressing transportation insecurity among patients with cancer. J Natl Cancer Inst 2022;114:1593\u20131600."},{"key":"B35","series-title":"Pediatr Blood Cancer","first-page":"S619","article-title":"Assessment of financial burden as a standard of care in pediatric oncology","volume":"62","author":"Pelletier W","year":"2015","unstructured":"Pelletier W, Bona K. Assessment of financial burden as a standard of care in pediatric oncology. Pediatr Blood Cancer 2015;62(Suppl 5):S619\u2013631."},{"key":"B36","series-title":"Pediatr Blood Cancer","first-page":"e32103","article-title":"Pediatric RISE: development of a poverty-targeted cash support intervention for pediatric cancer","volume":"73","author":"Kelly CA","year":"2026","unstructured":"Kelly CA, Paul MA, Kellett J,  Pediatric RISE: development of a poverty-targeted cash support intervention for pediatric cancer. Pediatr Blood Cancer 2026;73:e32103."},{"key":"B37","series-title":"Br J Haematol","first-page":"175","article-title":"Brain derived neurotropic factor single nucleotide polymorphism Val66Met and serum protein levels are associated with development of vincristine-induced peripheral neuropathy in patients with lymphoma","volume":"185","author":"Azoulay D","year":"2019","unstructured":"Azoulay D, Nasser R, Sharon R,  Brain derived neurotropic factor single nucleotide polymorphism Val66Met and serum protein levels are associated with development of vincristine-induced peripheral neuropathy in patients with lymphoma. Br J Haematol 2019;185:175\u2013177."},{"key":"B38","series-title":"Pediatr Phys Ther","first-page":"16","article-title":"Gait patterns in children with cancer and vincristine neuropathy","volume":"28","author":"Gilchrist L","year":"2016","unstructured":"Gilchrist L, Tanner L. Gait patterns in children with cancer and vincristine neuropathy. Pediatr Phys Ther 2016;28:16\u201322."},{"key":"B39","series-title":"Int J Environ Res Public Health","first-page":"1757","article-title":"Importance of social support of parents of children with cancer: a multicomponent model using partial least squares-path modelling","volume":"20","author":"Melguizo-Gar\u00edn A","year":"2023","unstructured":"Melguizo-Gar\u00edn A, Ben\u00edtez-M\u00e1rquez MD, Hombrados-Mendieta I, Martos-M\u00e9ndez MJ. Importance of social support of parents of children with cancer: a multicomponent model using partial least squares-path modelling. Int J Environ Res Public Health 2023;20:1757."},{"key":"B40","series-title":"Pediatr Blood Cancer","first-page":"269","article-title":"The relationship of parental overprotection, perceived vulnerability, and parenting stress to behavioral, emotional, and social adjustment in children with cancer","volume":"51","author":"Colletti CJM","year":"2008","unstructured":"Colletti CJM, Wolfe-Christensen C, Carpentier MY,  The relationship of parental overprotection, perceived vulnerability, and parenting stress to behavioral, emotional, and social adjustment in children with cancer. Pediatr Blood Cancer 2008;51:269\u2013274."},{"key":"B41","series-title":"Qual Life Res","first-page":"1373","article-title":"The relationship between parental overprotection and health-related quality of life in pediatric cancer: the mediating role of perceived child vulnerability","volume":"19","author":"Hullmann SE","year":"2010","unstructured":"Hullmann SE, Wolfe-Christensen C, Meyer WH,  The relationship between parental overprotection and health-related quality of life in pediatric cancer: the mediating role of perceived child vulnerability. Qual Life Res 2010;19:1373\u20131380."},{"key":"B42","series-title":"CA Cancer J Clin","first-page":"83","article-title":"Childhood and adolescent cancer statistics, 2014","volume":"64","author":"Ward E","year":"2014","unstructured":"Ward E, DeSantis C, Robbins A,  Childhood and adolescent cancer statistics, 2014. CA Cancer J Clin 2014;64:83\u2013103."},{"key":"B43","series-title":"Cancer Rep (Hoboken)","first-page":"e1424","article-title":"Listening to the experts: parents\u2019 perspectives around infection risk and returning to education and social activities following their child\u2019s diagnosis of acute lymphoblastic leukemia","volume":"5","author":"Ballantine K","year":"2022","unstructured":"Ballantine K, Gooder C, Ryan E, Macfarlane S. Listening to the experts: parents\u2019 perspectives around infection risk and returning to education and social activities following their child\u2019s diagnosis of acute lymphoblastic leukemia. Cancer Rep (Hoboken) 2022;5:e1424."},{"key":"B44","series-title":"Early Hum Dev","first-page":"105283","article-title":"Vulnerable child syndrome in the neonatal intensive care unit: a review and a new preventative intervention with feasibility and parental satisfaction data","volume":"154","author":"Hoge MK","year":"2021","unstructured":"Hoge MK, Heyne E, Nicholson TDF,  Vulnerable child syndrome in the neonatal intensive care unit: a review and a new preventative intervention with feasibility and parental satisfaction data. Early Hum Dev 2021;154:105283."},{"key":"B45","series-title":"J Dev Behav Pediatr","first-page":"371","article-title":"A model for the development of mothers\u2019 perceived vulnerability of preterm infants","volume":"36","author":"Horwitz SM","year":"2015","unstructured":"Horwitz SM, Storfer-Isser A, Kerker BD,  A model for the development of mothers\u2019 perceived vulnerability of preterm infants. J Dev Behav Pediatr 2015;36:371\u2013380."}],"container-title":["Journal of the National Comprehensive Cancer Network"],"original-title":[],"link":[{"URL":"https:\/\/jnccn.org\/view\/journals\/jnccn\/24\/10\/article-e267048.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jnccn.org\/downloadpdf\/journals\/jnccn\/24\/10\/article-e267048.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/jnccn.org\/downloadpdf\/journals\/jnccn\/24\/10\/article-e267048.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:40:39Z","timestamp":1791895239000},"score":1,"resource":{"primary":{"URL":"https:\/\/jnccn.org\/view\/journals\/jnccn\/24\/10\/article-e267048.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":45,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.6004\/jnccn.2026.7048","relation":{},"ISSN":["1540-1405","1540-1413"],"issn-type":[{"value":"1540-1405","type":"print"},{"value":"1540-1413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]}}}