{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:35:08Z","timestamp":1784759708158,"version":"3.55.0"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2020,11,30]]},"abstract":"<jats:p>The human epidermal growth factor (HER2) is a transmembrane receptor that is highly expressed in breast cancer and in different other cancers. Therefore, it is of interest to identify the new HER2 inhibitors from a selected 300 compounds in the ZINC database. The top two hit compounds (ZINC000014780728 (-11.0 kcal\/mol) and ZINC000014762512 (-10.8 kcal\/mol)) showed a high affinity with HER2 relative to the reference compound (lapatinib (-10.2 kcal\/mol)) for further consideration.<\/jats:p>","DOI":"10.6026\/97320630016882","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T04:08:46Z","timestamp":1604376526000},"page":"882","source":"Crossref","is-referenced-by-count":16,"title":["Molecular docking analysis of HER-2 inhibitor from the ZINC database as anticancer agents"],"prefix":"10.6026","volume":"16","author":[{"name":"Department of Obstetrics and Gynecology, Gynecology Oncology Unite, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid Hussain","family":"Wali Sait","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4070","published-online":{"date-parts":[[2020,11,30]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T04:08:59Z","timestamp":1604376539000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.bioinformation.net\/016\/97320630016882.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,30]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11,30]]},"published-print":{"date-parts":[[2020,11,30]]}},"URL":"https:\/\/doi.org\/10.6026\/97320630016882","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,30]]}}}