{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T20:30:02Z","timestamp":1769977802654,"version":"3.49.0"},"reference-count":0,"publisher":"Biomedical Informatics","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2021,8,31]]},"abstract":"<jats:p>High fat diet feeding results in hyperglycemia and insulin resistance, which is a major pathological feature of type-2 diabetes mellitus. The use of oral hypoglycaemic drugs is limited due to its deleterious side effects and there is a need to find more efficacious agents for diabetes management. Hence, it is of interest to show the mechanism of action of \u00df-Caryophyllene on insulin signalling molecules in gastrocnemius muscle of high fat diet- induced type-2 diabetic rats. An oral effective dose of with \u00df-Caryophyllene (200 mg\/kg b.wt) was given for 30 days to high fat diet (comprising 2% cholesterol, 1% cholic acid, 30% coconut oil, 67% conventional rat feed) and fructose fed type-2 diabetic rats to find out whether \u00df-Caryophyllene regulates IRS-1\/Akt pathway of insulin signalling. The data shows that, \u00df-Caryophyllene treatment significantly increased the mRNA and protein expression of insulin receptor (IR) in diabetic rats whereas there is no significant difference in mRNA expression of insulin receptor-substrate-1 (IRS-1) was observed among groups. The Akt mRNAand GLUT-4mRNA and protein level were also improved in gastrocnemius muscle of type-2 diabetic rats. Thus, we concluded that \u00df\u2013Caryophyllene could be used as potential phyto medicine for type-2 diabetes management.<\/jats:p>","DOI":"10.6026\/97320630017741","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T03:22:50Z","timestamp":1644895370000},"page":"741-747","source":"Crossref","is-referenced-by-count":6,"title":["Effect of \u00df-Caryophyllene on insulin resistance in skeletal muscle of high fat diet and fructose-induced type-2 diabetic rats"],"prefix":"10.6026","volume":"17","author":[{"name":"Department of Biochemistry, Arunai Medical College & Hospital, Tiruvanamallai-606603, Tamilnadu, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vadivel","family":"Mani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2021,8,31]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T03:22:56Z","timestamp":1644895376000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/017\/97320630017741.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,31]]},"references-count":0,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8,31]]},"published-print":{"date-parts":[[2021,8,31]]}},"URL":"https:\/\/doi.org\/10.6026\/97320630017741","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,31]]}}}