{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T04:22:44Z","timestamp":1679890964377},"reference-count":0,"publisher":"Biomedical Informatics","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2023,1,31]]},"abstract":"<jats:p>A metabolic condition called diabetes mellitus is linked to a number of substantial challenges. Advanced Glycation End Products (AGEs) and Aldose reductase (ALR2) are crucial in the slow development of several secondary complications. Selected calcium channel blockers (CCB\u2019s-1, 4-dihydropyridines) were docked against ALR2 (PDB code: 1Z3N) and RAGE (PDB code: 3CJJ) in the current study. We report that 1, 4-dihydropyridine compounds, particularly Benidipine, bind to the active sites with good efficiency. Thus, 1,4 dihydropyridine derivatives can be considered for further confirmation in drug discovery.<\/jats:p>","DOI":"10.6026\/97320630019028","type":"journal-article","created":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T06:21:36Z","timestamp":1679811696000},"page":"28-31","source":"Crossref","is-referenced-by-count":0,"title":["Molecular docking analysis of calcium channel blockers with ALR2 and RAGE"],"prefix":"10.6026","volume":"19","author":[{"given":"Samreen","family":"Kazmi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2023,1,31]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T06:21:44Z","timestamp":1679811704000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/019\/97320630019028.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,31]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,31]]},"published-print":{"date-parts":[[2023,1,31]]}},"URL":"https:\/\/doi.org\/10.6026\/97320630019028","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"value":"0973-8894","type":"print"},{"value":"0973-2063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,31]]}}}