{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T05:50:31Z","timestamp":1723096231344},"reference-count":0,"publisher":"Biomedical Informatics","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinformation"],"published-print":{"date-parts":[[2023,6,30]]},"abstract":"<jats:p>The use of antihistamine therapy in children for the management of upper respiratory tract infections remains a topic of debate. In this study, we focused on evaluating the effectiveness of promethazine (Phenergan), a first-generation H1 receptor antagonist and sedative, in addressing preoperative and intra-operative sequelae in cleft surgeries. A single-centered, parallel, randomized, double-blinded controlled clinical trial was conducted on 128 children aged 2 to 4 years undergoing cleft palate surgery under general anesthesia. The case group received Phenergan syrup orally twice a day for three days, while the control group received a placebo. Primary outcomes measured preoperative anxiety levels using a children's fear scale, while secondary outcomes assessed preoperative sleep quality and cough rate through objective scales. Intraoperative heart rate was monitored using an ECG connected to a monitor. The results demonstrated that the administration of promethazine resulted in a 34% reduction in anxiety levels, a 46% reduction in cold and cough, a 38% improvement in sleep score, and stable heart rates throughout the surgery compared to the control group. Based on these findings, promethazine is considered a safe premedication option for children undergoing cleft palate surgeries; given its benefits outweigh its adverse effects.<\/jats:p>","DOI":"10.6026\/97320630019790","type":"journal-article","created":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T11:05:35Z","timestamp":1695467135000},"page":"790-794","source":"Crossref","is-referenced-by-count":0,"title":["Effect of promethazine in cleft surgeries among Indian children"],"prefix":"10.6026","volume":"19","author":[{"name":"Department of Oral and Maxillofacial Surgery, Saveetha Institute of Medical & Technical Sciences (SIMATS), Saveetha University, Chennai, India","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alladi","family":"Sneha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4070","published-online":{"date-parts":[[2023,6,30]]},"container-title":["Bioinformation"],"original-title":[],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T11:06:25Z","timestamp":1695467185000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bioinformation.net\/019\/97320630019790.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,30]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6,30]]},"published-print":{"date-parts":[[2023,6,30]]}},"URL":"https:\/\/doi.org\/10.6026\/97320630019790","relation":{},"ISSN":["0973-8894","0973-2063"],"issn-type":[{"type":"print","value":"0973-8894"},{"type":"electronic","value":"0973-2063"}],"subject":[],"published":{"date-parts":[[2023,6,30]]}}}